Rizatriptan benzoate (苯甲酸利扎曲普坦; Maxalt) 是 5-HT1激动剂。
Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Williamson DJ, et al. Br J Pharmacol,?001, 133(7), 1029-1034.
[2] Cheng, H., et al.: Biopharm. Drug Dispos., 17, 17 (1996)
[3] Visser, W.H., et al.: rch. Neurol., 53, 1132 (1996)
分子式 C22H25N5O2 |
分子量 391.47 |
CAS号 145202-66-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 20 mg/mL |
Water 55 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01306266 | Chronic Post-traumatic Headache | Drug: Rizatriptan|Drug: Placebo | Henry M. Jackson Foundation for the Advancement of Military Medicine|Merck Sharp & Dohme Corp. | 2011-02-01 | 2015-08-17 | |
NCT01004263 | Acute Migraine With or Without Aura in Adolescents | Drug: rizatriptan benzoate | Merck Sharp & Dohme Corp. | Phase 3 | 2009-12-01 | 2015-09-24 |
NCT00397254 | Migraine | Drug: rizatriptan|Drug: rizatriptan | Clinvest|Merck Sharp & Dohme Corp. | Phase 4 | 2006-12-01 | 2010-06-07 |
NCT00812006 | Migraine | Drug: rizatriptan benzoate|Drug: Comparator: placebo | Merck Sharp & Dohme Corp. | Phase 3 | 2009-03-01 | 2015-02-13 |
NCT01286207 | Migraine Disorders | Drug: Rizatriptan 5 mg|Drug: Rizatriptan 10 mg|Drug: Standard Care | Merck Sharp & Dohme Corp. | Phase 3 | 1995-03-01 | 2015-02-13 |
NCT02447991 | Vestibular Migraine|Migrainous Vertigo | Drug: Rizatriptan|Drug: Placebo | Robert W. Baloh|University of California, Los Angeles | Phase 2|Phase 3 | 2014-12-01 | 2016-10-24 |
NCT00516737 | Migraine | Drug: Comparator: rizatriptan benzoate|Drug: Comparator: Placebo | Merck Sharp & Dohme Corp. | Phase 3 | 2007-10-01 | 2015-07-21 |
NCT00604812 | Migraine Disorders | Drug: rizatriptan benzoate (5 mg)|Drug: rizatriptan benzoate (10 mg)|Drug: Rizatriptan 5 mg Placebo|Drug: Rizatriptan 10 mg Placebo | Merck Sharp & Dohme Corp. | Phase 1 | 2007-12-01 | 2015-11-09 |
NCT00753311 | Migraine | Drug: rizatriptan or placebo | IRCCS San Raffaele|Merck Sharp & Dohme Corp. | Phase 4 | 2009-07-01 | 2011-10-07 |
NCT00897104 | Migraine Headache | Drug: rizatriptan benzoate (MK0462)|Drug: Comparator: sumatriptan|Drug: Comparator: Placebo | Merck Sharp & Dohme Corp. | Phase 3 | 1995-08-01 | 2015-02-13 |
NCT00899379 | Migraine Headache | Drug: rizatriptan benzoate|Drug: Comparator: Placebo | Merck Sharp & Dohme Corp. | Phase 3 | 1995-04-01 | 2015-03-17 |
NCT00897949 | Migraine Headache | Drug: rizatriptan benzoate (MK0462)|Drug: Comparator: placebo | Merck Sharp & Dohme Corp. | Phase 3 | 1995-03-01 | 2015-02-13 |
NCT00898677 | Migraine Headache | Drug: rizatriptan benzoate|Drug: rizatriptan benzoate|Drug: Comparator: sumatriptan|Drug: Comparator: Placebo | Merck Sharp & Dohme Corp. | Phase 3 | 1995-09-01 | 2015-02-13 |
NCT01001234 | Migraine, Acute | Drug: rizatriptan|Drug: placebo|Drug: rizatriptan|Drug: placebo | Merck Sharp & Dohme Corp. | Phase 3 | 2009-11-01 | 2015-09-24 |
NCT00719134 | Episodic Migraine | Drug: Maxalt|Drug: placebo pill|Drug: placebo pills | Beth Israel Deaconess Medical Center | Phase 4 | 2008-09-01 | 2015-04-08 |
NCT00471952 | Migraine With Aura|Migraine Without Aura | Drug: Maxalt 10mg MLT plus Caffeine 75mg|Drug: Maxalt 10mg MLT plus Placebo|Drug: Placebo + Placebo | Diamond Headache Clinic|Merck Sharp & Dohme Corp. | Phase 3 | 2007-04-01 | 2012-04-24 |
NCT00360282 | Migraine | Drug: Rizatriptan|Other: Placebo | University of Pittsburgh|Merck Sharp & Dohme Corp. | 2006-08-01 | 2014-12-04 | |
NCT00300924 | Migraine | Drug: Rizatriptan co-administered with Acetaminophen | Diamond Headache Clinic|Merck Sharp & Dohme Corp. | Phase 3 | 2006-03-01 | 2008-05-27 |
NCT00894556 | Acute Migraine | Drug: rizatriptan|Drug: Comparator: Placebo|Drug: Comparator: Sumatriptan | Merck Sharp & Dohme Corp. | Phase 3 | 2009-06-01 | 2015-03-24 |
NCT00250458 | Migraine | Drug: Comparator: Rizatriptan|Drug: Comparator: Placebo | Merck Sharp & Dohme Corp. | Phase 3 | 2006-03-01 | 2015-10-30 |
NCT00632385 | Migraine | Drug: Eletriptan | Pfizer | Phase 4 | 2003-01-01 | 2011-04-22 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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