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Rizatriptan Benzoate

苯甲酸利扎曲坦,MK-462 Benzoate,MK462 Benzoate,MK 462 Benzoate

Rizatriptan benzoate (苯甲酸利扎曲普坦; Maxalt) 是 5-HT1激动剂。

目录号
EY0764
EY0764
EY0764
纯度
99.38%
99.38%
99.38%
规格
5 mg
10 mg
50 mg
原价
260
432
1500
售价
260
432
1500
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Williamson DJ, et al. Br J Pharmacol,?001, 133(7), 1029-1034.
    [2] Cheng, H., et al.: Biopharm. Drug Dispos., 17, 17 (1996)
    [3] Visser, W.H., et al.: rch. Neurol., 53, 1132 (1996)

    分子式
    C22H25N5O2
    分子量
    391.47
    CAS号
    145202-66-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    20 mg/mL
    Water
    55 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01306266 Chronic Post-traumatic Headache Drug: Rizatriptan|Drug: Placebo Henry M. Jackson Foundation for the Advancement of Military Medicine|Merck Sharp & Dohme Corp. 2011-02-01 2015-08-17
    NCT01004263 Acute Migraine With or Without Aura in Adolescents Drug: rizatriptan benzoate Merck Sharp & Dohme Corp. Phase 3 2009-12-01 2015-09-24
    NCT00397254 Migraine Drug: rizatriptan|Drug: rizatriptan Clinvest|Merck Sharp & Dohme Corp. Phase 4 2006-12-01 2010-06-07
    NCT00812006 Migraine Drug: rizatriptan benzoate|Drug: Comparator: placebo Merck Sharp & Dohme Corp. Phase 3 2009-03-01 2015-02-13
    NCT01286207 Migraine Disorders Drug: Rizatriptan 5 mg|Drug: Rizatriptan 10 mg|Drug: Standard Care Merck Sharp & Dohme Corp. Phase 3 1995-03-01 2015-02-13
    NCT02447991 Vestibular Migraine|Migrainous Vertigo Drug: Rizatriptan|Drug: Placebo Robert W. Baloh|University of California, Los Angeles Phase 2|Phase 3 2014-12-01 2016-10-24
    NCT00516737 Migraine Drug: Comparator: rizatriptan benzoate|Drug: Comparator: Placebo Merck Sharp & Dohme Corp. Phase 3 2007-10-01 2015-07-21
    NCT00604812 Migraine Disorders Drug: rizatriptan benzoate (5 mg)|Drug: rizatriptan benzoate (10 mg)|Drug: Rizatriptan 5 mg Placebo|Drug: Rizatriptan 10 mg Placebo Merck Sharp & Dohme Corp. Phase 1 2007-12-01 2015-11-09
    NCT00753311 Migraine Drug: rizatriptan or placebo IRCCS San Raffaele|Merck Sharp & Dohme Corp. Phase 4 2009-07-01 2011-10-07
    NCT00897104 Migraine Headache Drug: rizatriptan benzoate (MK0462)|Drug: Comparator: sumatriptan|Drug: Comparator: Placebo Merck Sharp & Dohme Corp. Phase 3 1995-08-01 2015-02-13
    NCT00899379 Migraine Headache Drug: rizatriptan benzoate|Drug: Comparator: Placebo Merck Sharp & Dohme Corp. Phase 3 1995-04-01 2015-03-17
    NCT00897949 Migraine Headache Drug: rizatriptan benzoate (MK0462)|Drug: Comparator: placebo Merck Sharp & Dohme Corp. Phase 3 1995-03-01 2015-02-13
    NCT00898677 Migraine Headache Drug: rizatriptan benzoate|Drug: rizatriptan benzoate|Drug: Comparator: sumatriptan|Drug: Comparator: Placebo Merck Sharp & Dohme Corp. Phase 3 1995-09-01 2015-02-13
    NCT01001234 Migraine, Acute Drug: rizatriptan|Drug: placebo|Drug: rizatriptan|Drug: placebo Merck Sharp & Dohme Corp. Phase 3 2009-11-01 2015-09-24
    NCT00719134 Episodic Migraine Drug: Maxalt|Drug: placebo pill|Drug: placebo pills Beth Israel Deaconess Medical Center Phase 4 2008-09-01 2015-04-08
    NCT00471952 Migraine With Aura|Migraine Without Aura Drug: Maxalt 10mg MLT plus Caffeine 75mg|Drug: Maxalt 10mg MLT plus Placebo|Drug: Placebo + Placebo Diamond Headache Clinic|Merck Sharp & Dohme Corp. Phase 3 2007-04-01 2012-04-24
    NCT00360282 Migraine Drug: Rizatriptan|Other: Placebo University of Pittsburgh|Merck Sharp & Dohme Corp. 2006-08-01 2014-12-04
    NCT00300924 Migraine Drug: Rizatriptan co-administered with Acetaminophen Diamond Headache Clinic|Merck Sharp & Dohme Corp. Phase 3 2006-03-01 2008-05-27
    NCT00894556 Acute Migraine Drug: rizatriptan|Drug: Comparator: Placebo|Drug: Comparator: Sumatriptan Merck Sharp & Dohme Corp. Phase 3 2009-06-01 2015-03-24
    NCT00250458 Migraine Drug: Comparator: Rizatriptan|Drug: Comparator: Placebo Merck Sharp & Dohme Corp. Phase 3 2006-03-01 2015-10-30
    NCT00632385 Migraine Drug: Eletriptan Pfizer Phase 4 2003-01-01 2011-04-22

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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