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Methylprednisolone

甲基强的松龙,NSC-19987,NSC19987,NSC 19987

Methylprednisolone是皮质类固醇，可作用于糖皮质激素受体。

目录号
EY0746
EY0746
EY0746
纯度
99.38%
99.38%
99.38%
规格
10 mg
50 mg
100 mg
原价
200
300
500
售价
200
300
500
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Marchant A, et al. Clin Exp Immunol,?996, 106(1), 91-96.
    [2] Yamaguchi S, Ohsaki Y, Nishigaki Y et al. Int J Oncol. 15:1185-90 (1999).
    [3] Wang J, Lia H, Chen X, Chung Hua et al. Chinese Journal of Internal Medicine. 36:79-82 (1997).

    分子式
    C22H30O5    		 分子量
    374.47    		 CAS号
    83-43-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    75 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01305837 Progressive Multiple Sclerosis Drug: methylprednisolone Rigshospitalet, Denmark Phase 2 2011-04-01 2013-07-10
    NCT01217099 Refractory Mycoplasma Pneumoniae Pneumonia Drug: methylprednisolone|Drug: azithromycin Chongqing Medical University 2007-05-01 2010-10-07
    NCT00989729 Abdominal Aortic Aneurysms Drug: Methylprednisolone|Drug: Physiological Saline Louise de la Motte|Rigshospitalet, Denmark 2009-10-01 2014-11-12
    NCT00128180 Hantavirus Infections Drug: Methylprednisolone|Drug: Placebo University of New Mexico|National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2003-01-01 2014-12-05
    NCT00968903 LOS|Postoperative Pain|Postoperative Nausea and Vomiting|Sleeping Quality|Fatigue|Inflammatory Response Drug: Methylprednisolone Hvidovre University Hospital|Lundbeck Foundation Phase 4 2010-04-01 2011-09-28
    NCT02424435 Friedreich Ataxia Drug: Methylprednisolone Children's Hospital of Philadelphia|Friedreich's Ataxia Research Alliance Early Phase 1 2015-06-01 2017-01-09
    NCT01790022 Ankylosing Spondylitis Drug: Methylprednisolone Saratov State Medical University|Charite University, Berlin, Germany Phase 2 2012-07-01 2013-02-09
    NCT01726465 Ischemic Reperfusion Injury|Insufficiency; Hepatic, Postoperative|Liver Tumour Drug: Methylprednisolone|Drug: N-acetylcysteine Istituto Clinico Humanitas Phase 2 2012-11-01 2013-11-09
    NCT02769689 Multiple Sclerosis Drug: Methylprednisolone|Drug: Placebo|Drug: natalizumab (NTZ)|Drug: fingolimob (FTY) University Hospital, Clermont-Ferrand Phase 4 2016-04-01 2016-05-09
    NCT01277731 Dexamethasone|Hiccup Drug: Methylprednisolone Gyeongsang National University Hospital 2010-07-01 2012-11-18
    NCT02319343 Osteoarthrosis Drug: Methylprednisolone|Drug: Isotonic Sodium Chloride Rigshospitalet, Denmark|Bispebjerg Hospital Phase 3 2015-01-01 2016-04-07
    NCT02332616 Osteoarthrosis Drug: Methylprednisolone|Drug: Isotonic Sodium Chloride Rigshospitalet, Denmark|Bispebjerg Hospital Phase 3 2015-01-01 2016-04-07
    NCT02332629 Osteoarthrosis Drug: Methylprednisolone|Drug: Isotonic Sodium Chloride Rigshospitalet, Denmark|Bispebjerg Hospital Phase 3 2015-01-01 2016-04-07
    NCT02332603 Osteoarthrosis Drug: Methylprednisolone|Drug: Isotonic Sodium Chloride Rigshospitalet, Denmark|Bispebjerg Hospital Phase 3 2015-01-01 2017-01-17
    NCT00968578 Postoperative Pain|Postoperative Nausea and Vomiting|Sleeping Quality|Fatigue|Inflammatory Response Drug: Methylprednisolone|Drug: Placebo Hvidovre University Hospital|Lundbeck Foundation Phase 4 2009-08-01 2012-09-25
    NCT02445898 Osteoarthrosis Drug: Methylprednisolone|Drug: Isotonic Sodium Chloride Rigshospitalet, Denmark|Bispebjerg Hospital Phase 2|Phase 3 2015-09-01 2017-01-17
    NCT02711449 Suspected Appendicitis Drug: Methylprednisolone|Drug: 0.9% Saline Jakob Kleif|Zealand University Hospital|Nordsjaellands Hospital Phase 2 2016-04-01 2016-09-24
    NCT02542592 Osteoarthrosis Drug: Methylprednisolone|Drug: Isotonic Sodium Chloride Rigshospitalet, Denmark|Bispebjerg Hospital Phase 2|Phase 3 2015-09-01 2017-01-17
    NCT02331862 Urinary Tract Infection Drug: Methylprednisolone National Cheng-Kung University Hospital Phase 3 2015-01-01 2015-01-04
    NCT01106547 Hysterectomy|Methylprednisolone|Postoperative Pain Drug: Methylprednisolone 125mg|Drug: Sodium Chloride 2 ml Holbaek Sygehus Phase 4 2009-08-01 2011-10-12
    NCT00558181 Chronic B-Lymphocytic Leukemia Drug: rituximab, methylprednisolone Vilnius University Phase 2 2007-09-01 2010-02-22

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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