Home > MAO  & > Sennoside A

Sennoside A

番泻苷A,NSC 112929,NSC112929,NSC-112929

Sennoside A是一种从大黄根茎中分离得到的刺激性泻药，在肠道中引起通便作用。

目录号
EY0739
EY0739
EY0739
EY0739
EY0739
纯度
99.32%
99.32%
99.32%
99.32%
99.32%
规格
1 mg
5 mg
10 mg
20 mg
50 mg
原价
162
590
970
1398.00
2600
售价
162
590
970
1398.00
2600
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Hiraoka A, et al. Chem Pharm Bull, 1989, 37(10), 2744-2746.

    分子式
    C42H38O20    		 分子量
    862.74    		 CAS号
    81-27-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00571896 Constipation Drug: Senna+ docusate|Drug: placebo Hartford Hospital Phase 2|Phase 3 2008-01-01 2012-01-03
    NCT02239510 Chronic Idiopathic Constipation Drug: Senna|Drug: Linzess TriHealth Inc. 2014-09-01 2016-10-28
    NCT02618564 Colonoscopy Preparation Outcome Drug: Sennosides Queen's University 2015-12-01 2017-02-14
    NCT02008864 End Stage Renal Disease|Pruritus Drug: Senna|Drug: Placebo Shiraz University of Medical Sciences 2011-08-01 2015-03-30
    NCT00990951 Constipation Drug: Senna alexandrina and associations Marjan Industria e Comercio ltda Phase 3 2010-06-01 2014-07-07
    NCT01531140 Colonoscopy Preparation Drug: polyethylene glycol +Bisacodyl|Drug: Polyethylene glycol|Drug: Sennosides Medical University of Warsaw|Institute of Child Health Phase 4 2010-11-01 2012-02-09
    NCT01140295 Colonoscopy Preparation Drug: polyethylene glycol, senna Children's Hospital of Philadelphia Phase 4 2010-09-01 2013-04-10
    NCT01189409 Constipation|Cancer Drug: PEG then Senna|Drug: Senna then PEG British Columbia Cancer Agency Phase 4 2010-06-01 2015-07-23
    NCT00390598 Colonoscopy Drug: PEG (solution given 4 L)|Drug: senna glycoside 36 mg and PEG (solution given 2 L) Ume氓 University Phase 2|Phase 3 2005-09-01 2011-03-23
    NCT00931853 Constipation Drug: SENNA+CASSIA(Naturetti) Sanofi Phase 3 2010-09-01 2012-10-16
    NCT00994851 Constipation Drug: SENNA+CASSIA|Drug: placebo Sanofi Phase 3 2009-09-01 2013-03-28
    NCT01057446 Colonoscopy Maltepe University|Marmara University 2010-02-04
    NCT00902031 Constipation|Palliative Care Drug: Docusate Sodium, Sennoside|Drug: Sennoside + Placebo University of Alberta|College of Family Physicians of Canada (Janus Research Grant)|Covenant Health|Capital Care 2006-04-01 2011-04-19
    NCT01695850 Functional Constipation|Gastrointestinal Disorders Drug: MZRW|Drug: Senna|Drug: placebo Hong Kong Baptist University|Queen Elizabeth Hospital, Hong Kong|Prince of Wales Hospital, Shatin, Hong Kong Phase 2 2013-06-01 2016-08-15
    NCT00662363 Constipation Drug: Lubiprostone|Drug: Senna Rehabilitation Institute of Chicago|Takeda Pharmaceuticals North America, Inc. 2008-04-01 2013-02-27
    NCT00460837 Colorectal Cancer Drug: bowel preparation: senna & gastrofin versus picolax (standard) London North West Healthcare NHS Trust Phase 4 2007-11-01 2010-07-23
    NCT00275184 Small Bowel Disease|Gastrointestinal Hemorrhage|Refractory Anemia Drug: Senna|Drug: Citramag powder|Drug: Metoclopramide London North West Healthcare NHS Trust Phase 3 2006-01-01 2007-09-21
    NCT01773096 Constipation Drug: Methylnaltrexone|Drug: Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax Shriners Hospitals for Children Phase 4 2013-05-01 2015-05-15

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：