Neomycin sulfate是氨基糖苷类抗生素,是钙离子通道抑制剂。
Neomycin sulphate is an aminoglycoside antibiotic, used to treat bacteria infections.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Stage TK, et al. RNA,1995,(1), 95-101.
[2] Vergara, J., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 6352-6356.
[3] Gabev, E., et al. 1989. Biochim. Biophys. Acta. 979: 105-112.
[4] Woegerbauer, M., et al. 2000. J. Antibiot. 53: 276-285.
[5] Liscovitch, M., et al. 1991. Biochem. J. 279: 319-321.
分子式 C23H46N6O13 |
分子量 614.64 |
CAS号 1405-10-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water ≥50 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02001909 | Neoplasms | Drug: Regorafenib (Stivarga, BAY73-4506)|Drug: Neomycin | Bayer | Phase 1 | 2013-12-01 | 2015-08-12 |
NCT00945334 | Constipation-predominant Irritable Bowel Syndrome | Drug: Neomycin|Drug: Placebo|Drug: Rifaximin | Mark Pimentel, MD|Valeant Pharmaceuticals International, Inc.|Cedars-Sinai Medical Center | 2009-08-01 | 2015-07-17 | |
NCT00857688 | Aphtous Ulcers | Drug: Bismu-Jet|Other: Placebo | Azidus Brasil | Phase 3 | 2011-05-01 | 2013-02-22 |
NCT02472600 | Intestinal Colonization With Multidrug-resistant Bacteria | Drug: Colistin|Drug: Neomycin|Drug: Fecal microbiota transplantation (FMT)|Drug: Omeprazole | Stephen Harbarth|European Commission|University Hospital, Geneva | Phase 2 | 2016-02-01 | 2016-09-29 |
NCT03042091 | Colorectal Neoplasms|Diverticulitis|Inflammatory Bowel Diseases|Surgical Site Infection | Drug: Polyethylene Glycol|Drug: Neomycin|Drug: Metronidazole Hydrochloride|Procedure: Therapeutic Conventional Surgery | Sidney Kimmel Cancer Center at Thomas Jefferson University|Thomas Jefferson University | Early Phase 1 | 2016-09-01 | 2017-02-14 |
NCT02682485 | Anastomotic Leak|Rectal Cancer | Drug: Cipro, metronidazole, neomycin combo|Procedure: Serial Endoscopic Surveillance|Drug: Saline | University of Chicago | Phase 2 | 2017-01-01 | 2017-01-10 |
NCT00534391 | Hordeolum | Drug: neomycin sulfate, polymyxin B sulfate and gramicidin|Drug: Artificial tear | Chulalongkorn University | Phase 3 | 2007-09-01 | 2010-11-22 |
NCT01638429 | Diabetes|Obesity | Drug: Neomycin and Rifaximin | Cedars-Sinai Medical Center|American Diabetes Association | 2012-07-01 | 2014-04-01 | |
NCT00166868 | Biliary Atresia | Drug: Lactobacillus casei rhamnosus (Lcr35)|Drug: Neomycin | National Taiwan University Hospital | 2003-12-01 | 2013-08-19 | |
NCT01798537 | Bacteremia Associated With Intravascular Line|Ventilator Associated Pneumonia|Bacteremia | Drug: Neomycin Colistin Nystatin Vancomycin | Rambam Health Care Campus | Phase 2|Phase 3 | 2013-06-01 | 2013-02-25 |
NCT01227863 | Bacterial Conjunctivitis|Acute | Drug: MAXINOM庐|Drug: Maxitrol庐 | Azidus Brasil | Phase 3 | 2011-02-01 | 2010-10-22 |
NCT00058617 | Epstein-Barr Virus-Related Hodgkin Lymphoma|Epstein-Barr Virus-Related Non-Hodgkin Lymphoma|EBV Positive Plasma Cell Neoplasm | Biological: Injection of EBV Specific CTLs | Baylor College of Medicine|Texas Children's Hospital|The Methodist Hospital System|Center for Cell and Gene Therapy, Baylor College of Medicine | Phase 1 | 1996-01-01 | 2017-02-13 |
NCT02444481 | Vaginitis | Drug: Polygynax combinaison of polymyxin, Neomycin and Nystatin | Laboratoire Innotech International | Phase 4 | 2009-04-01 | 2015-05-11 |
NCT02168478 | Allergy | Drug: Neo-Synalar Cream|Other: Sodium Lauryl Sulfate Aqueous Solution (0.40%)|Other: Saline | Noah Rosenberg, MD|Medimetriks Pharmaceuticals, Inc | Phase 4 | 2014-06-01 | 2015-11-05 |
NCT02652637 | Colorectal Surgery | Drug: neomycin, metronidazole, polyethylene glycol (PEG) | Helsinki University Central Hospital | Phase 4 | 2016-02-01 | 2016-12-04 |
NCT03006809 | Ulcerative Colitis | Biological: Fecal Microbiota Transplantation (FMT), OpenBiome|Other: pretreatment antibiotics | Najwa Elnachef|University of California, San Francisco | Phase 1 | 2017-04-01 | 2017-03-16 |
NCT02582255 | Poliomyelitis | Biological: Sabin mOPV2 | Fidec Corporation|Bill and Melinda Gates Foundation | Phase 4 | 2015-11-01 | 2015-10-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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