Liothyronine Sodium是甲状腺激素的最有效形式,提高基础代谢率,影响蛋白质的合成。
Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Timmer DC, et al. J Endocrinol, 2003, 179(2), 217-225.
[2] Lanni, A., et al. 1993. J. Endocrinol. 136: 59-64.
[3] Green, N.K., et al. 1993. Clin. Sci. 84: 61-67.
分子式 C15H12I3NO4.Na |
分子量 672.96 |
CAS号 55-06-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 90 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01481402 | Heart Failure|Low T3 Syndrome | Drug: Liothyronine|Drug: Liothyronine | Jens Faber|Herlev Hospital | 2011-07-01 | 2014-02-25 | |
NCT00790738 | Depression|Bipolar Disorder | Drug: Liothyronine (T3)|Drug: placebo | Northwell Health|National Alliance for Research on Schizophrenia and Depression | Phase 3 | 2008-07-01 | 2015-06-05 |
NCT01581463 | Healthy | Drug: Liothyronine, Sodium | Ipe, LLC | Phase 1 | 2012-04-01 | 2012-08-03 |
NCT01299337 | Depression | Drug: T3 | Mayo Clinic | Phase 1 | 2008-06-01 | 2012-05-10 |
NCT01780584 | Low T3 Syndrome | Drug: Oral T3 Low dose|Drug: Placebo|Drug: Oral T3 high dose | National Cardiovascular Center Harapan Kita Hospital Indonesia | Phase 2 | 2010-04-01 | 2013-02-02 |
NCT00531713 | Quality of Life|Depression | Drug: Triiodothyronine | Copenhagen University Hospital at Herlev | Phase 4 | 2003-04-01 | 2007-09-18 |
NCT00978055 | Healthy | Drug: 1: Liothyronine Sodium Tablets|Drug: 2: Cytomel庐 Tablets | Mylan Pharmaceuticals | Phase 1 | 2007-10-01 | 2009-09-15 |
NCT00488644 | Hypothyroidism|Brain Tumor | Drug: Levothyroxine|Drug: Liothyronine | M.D. Anderson Cancer Center | 2006-02-01 | 2013-06-14 | |
NCT01153360 | Non-thyroidal Illness Syndrome | Drug: liothyronine sodium|Drug: placebo | Yonsei University | 2010-06-01 | 2012-07-23 | |
NCT02506751 | Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis, Primary Progressive | Drug: liothyronine | Johns Hopkins University | Phase 1 | 2015-07-01 | 2016-09-05 |
NCT02320669 | Congenital Heart Defects | Drug: Triostat|Drug: Placebo | Seattle Children's Hospital | Phase 3 | 2014-11-01 | 2016-10-13 |
NCT00027417 | Heart Defects, Congenital | Drug: Liothyronine sodium/triiodothyronine|Procedure: Cardiopulmonary bypass and cardiac surgery | Michael Portman|Seattle Children's Hospital | Phase 3 | 2001-04-01 | 2013-08-01 |
NCT02161874 | Partial Edentulism|Tooth Disease | Device: T3 with DCD tapered Prevail implant|Device: Nanotite Certain tapered implant | Zimmer Biomet | 2013-04-01 | 2017-03-20 | |
NCT00715572 | Hypothyroidism | Drug: thyroxine|Drug: thyroxine and triiodothyronine | I.M. Sechenov First Moscow State Medical University | 2002-03-01 | 2008-07-14 | |
NCT02560753 | Alzheimer's Disease | Drug: T3D-959 | T3D Therapeutics, Inc. | Phase 1|Phase 2 | 2015-07-01 | 2016-06-06 |
NCT00106119 | Thyroid Diseases | Drug: Liothyronine and Levothyroxine | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2005-03-01 | 2015-02-20 |
NCT01800617 | Hypothyroidism | Drug: Liothyronine, Sodium | Ipe, LLC | Phase 2 | 2013-03-01 | 2014-07-01 |
NCT02521168 | Postoperative; Dysfunction Following Cardiac Surgery | Drug: Oral triiodothyronine|Drug: Placebo | National Cardiovascular Center Harapan Kita Hospital Indonesia|CRDF Global|Osypka Germany|Dalim BioTech Co., Ltd. | Phase 3 | 2013-07-01 | 2016-02-16 |
NCT00903877 | Fibromyalgia | Drug: T3|Drug: Placebo | Stanford University | 2009-05-01 | 2012-06-21 | |
NCT02399475 | Subclinical Hypothyroidism | Drug: Levothyroxine|Drug: Liothyronine|Drug: Thyrotropin-Releasing Hormone | University of Pennsylvania|National Institute on Aging (NIA) | 2015-01-01 | 2016-04-11 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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