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Liothyronine Sodium

三碘代甲状腺素钠盐

Liothyronine Sodium是甲状腺激素的最有效形式,提高基础代谢率,影响蛋白质的合成。

目录号
EY0721
EY0721
纯度
99.38%
99.38%
规格
100 mg
500 mg
原价
380
980
售价
380
980
库存
现货
现货
订购
订购
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  • 生物活性

    Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Timmer DC, et al. J Endocrinol, 2003, 179(2), 217-225.
    [2] Lanni, A., et al. 1993. J. Endocrinol. 136: 59-64.
    [3] Green, N.K., et al. 1993. Clin. Sci. 84: 61-67.

    分子式
    C15H12I3NO4.Na
    分子量
    672.96
    CAS号
    55-06-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    90 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01481402 Heart Failure|Low T3 Syndrome Drug: Liothyronine|Drug: Liothyronine Jens Faber|Herlev Hospital 2011-07-01 2014-02-25
    NCT00790738 Depression|Bipolar Disorder Drug: Liothyronine (T3)|Drug: placebo Northwell Health|National Alliance for Research on Schizophrenia and Depression Phase 3 2008-07-01 2015-06-05
    NCT01581463 Healthy Drug: Liothyronine, Sodium Ipe, LLC Phase 1 2012-04-01 2012-08-03
    NCT01299337 Depression Drug: T3 Mayo Clinic Phase 1 2008-06-01 2012-05-10
    NCT01780584 Low T3 Syndrome Drug: Oral T3 Low dose|Drug: Placebo|Drug: Oral T3 high dose National Cardiovascular Center Harapan Kita Hospital Indonesia Phase 2 2010-04-01 2013-02-02
    NCT00531713 Quality of Life|Depression Drug: Triiodothyronine Copenhagen University Hospital at Herlev Phase 4 2003-04-01 2007-09-18
    NCT00978055 Healthy Drug: 1: Liothyronine Sodium Tablets|Drug: 2: Cytomel庐 Tablets Mylan Pharmaceuticals Phase 1 2007-10-01 2009-09-15
    NCT00488644 Hypothyroidism|Brain Tumor Drug: Levothyroxine|Drug: Liothyronine M.D. Anderson Cancer Center 2006-02-01 2013-06-14
    NCT01153360 Non-thyroidal Illness Syndrome Drug: liothyronine sodium|Drug: placebo Yonsei University 2010-06-01 2012-07-23
    NCT02506751 Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis, Primary Progressive Drug: liothyronine Johns Hopkins University Phase 1 2015-07-01 2016-09-05
    NCT02320669 Congenital Heart Defects Drug: Triostat|Drug: Placebo Seattle Children's Hospital Phase 3 2014-11-01 2016-10-13
    NCT00027417 Heart Defects, Congenital Drug: Liothyronine sodium/triiodothyronine|Procedure: Cardiopulmonary bypass and cardiac surgery Michael Portman|Seattle Children's Hospital Phase 3 2001-04-01 2013-08-01
    NCT02161874 Partial Edentulism|Tooth Disease Device: T3 with DCD tapered Prevail implant|Device: Nanotite Certain tapered implant Zimmer Biomet 2013-04-01 2017-03-20
    NCT00715572 Hypothyroidism Drug: thyroxine|Drug: thyroxine and triiodothyronine I.M. Sechenov First Moscow State Medical University 2002-03-01 2008-07-14
    NCT02560753 Alzheimer's Disease Drug: T3D-959 T3D Therapeutics, Inc. Phase 1|Phase 2 2015-07-01 2016-06-06
    NCT00106119 Thyroid Diseases Drug: Liothyronine and Levothyroxine National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Phase 2 2005-03-01 2015-02-20
    NCT01800617 Hypothyroidism Drug: Liothyronine, Sodium Ipe, LLC Phase 2 2013-03-01 2014-07-01
    NCT02521168 Postoperative; Dysfunction Following Cardiac Surgery Drug: Oral triiodothyronine|Drug: Placebo National Cardiovascular Center Harapan Kita Hospital Indonesia|CRDF Global|Osypka Germany|Dalim BioTech Co., Ltd. Phase 3 2013-07-01 2016-02-16
    NCT00903877 Fibromyalgia Drug: T3|Drug: Placebo Stanford University 2009-05-01 2012-06-21
    NCT02399475 Subclinical Hypothyroidism Drug: Levothyroxine|Drug: Liothyronine|Drug: Thyrotropin-Releasing Hormone University of Pennsylvania|National Institute on Aging (NIA) 2015-01-01 2016-04-11

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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