Benztropine mesylate

甲磺酸苯扎托品,Benzatropine,Benzotropine mesylate

Benzotropine是抗毒蕈碱的化合物,多巴胺转运蛋白抑制剂,IC50为118 nM,可辅助治疗帕金森病。

目录号
EY0715
EY0715
EY0715
纯度
99.65%
99.65%
99.65%
规格
100 mg
500 mg
1 g
原价
135
386
490
售价
135
386
490
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Simoni D, et al. J Med Chem, 2005, 48(9), 3337-3343.
    [2] Gao, Z.G., et al. 1998. J. Pharm. Pharmacol. 50: 1299-1305.
    [3] Bowers, M.B. and Roth, R.H. 1972. Br. J. Pharmacol. 44: 301-306.

    分子式
    C22H29NO4S
    分子量
    403.53
    CAS号
    132-17-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    81 mg/mL
    Ethanol
    81 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00000333 Cocaine-Related Disorders Drug: Benztropine National Institute on Drug Abuse (NIDA)|Washington D.C. Veterans Affairs Medical Center Phase 2 2001-05-01 2017-02-23
    NCT00715377 Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Delusional Disorder|Psychotic Disorders Drug: Benztropine Centre for Addiction and Mental Health 2007-06-01 2015-08-21
    NCT00018200 Back Pain|Sciatica Drug: Desipramine|Drug: Fluoxetine|Drug: Benztropine VA Office of Research and Development Phase 2 1999-04-01 2012-06-04
    NCT00457366 Agitation Drug: Quetiapine|Drug: Cocktail (Haloperidol, Lorazepam, Cogentin) University of Southern California|AstraZeneca Phase 4 2006-05-01 2014-01-29
    NCT00000793 HIV Infections|Peripheral Nervous System Disease Drug: Mexiletine hydrochloride|Drug: Benztropine mesylate|Drug: Amitriptyline hydrochloride National Institute of Allergy and Infectious Diseases (NIAID)|Boehringer Ingelheim Phase 2 null 2012-04-02
    NCT00964886 Back Pain Behavioral: cognitive behavioral therapy|Drug: desipramine hydrochloride|Behavioral: cognitive behavioral therapy|Drug: benztropine mesylate 0.125 mg daily|Drug: desipramine hydrochloride VA Office of Research and Development|University of California, San Diego Phase 2 2010-01-01 2016-11-23
    NCT00802100 Schizophrenia Drug: Olanzapine|Drug: Perphenazine|Drug: Aripiprazole|Drug: Metformin|Drug: Simvastatin|Drug: Benztropine National Institute of Mental Health (NIMH) Phase 4 2008-12-01 2013-01-03
    NCT00167856 Neuropathic Pain|Pain|Spinal Cord Injuries Drug: Venalafaxine hydrochloride VA Office of Research and Development 2005-06-01 2014-03-26
    NCT00009672 Radiculopathy|Sciatica Drug: Nortriptyline|Drug: Morphine National Institute of Dental and Craniofacial Research (NIDCR)|National Institutes of Health Clinical Center (CC) Phase 2 2001-01-30 2017-01-24
    NCT01833897 Bipolar Disorder Drug: Standard of Care|Drug: Ketamine|Drug: D-cycloserine New York State Psychiatric Institute Phase 4 2013-03-01 2016-04-25

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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