Benzotropine是抗毒蕈碱的化合物,多巴胺转运蛋白抑制剂,IC50为118 nM,可辅助治疗帕金森病。
Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Simoni D, et al. J Med Chem, 2005, 48(9), 3337-3343.
[2] Gao, Z.G., et al. 1998. J. Pharm. Pharmacol. 50: 1299-1305.
[3] Bowers, M.B. and Roth, R.H. 1972. Br. J. Pharmacol. 44: 301-306.
分子式 C22H29NO4S |
分子量 403.53 |
CAS号 132-17-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water 81 mg/mL |
Ethanol 81 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00000333 | Cocaine-Related Disorders | Drug: Benztropine | National Institute on Drug Abuse (NIDA)|Washington D.C. Veterans Affairs Medical Center | Phase 2 | 2001-05-01 | 2017-02-23 |
NCT00715377 | Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Delusional Disorder|Psychotic Disorders | Drug: Benztropine | Centre for Addiction and Mental Health | 2007-06-01 | 2015-08-21 | |
NCT00018200 | Back Pain|Sciatica | Drug: Desipramine|Drug: Fluoxetine|Drug: Benztropine | VA Office of Research and Development | Phase 2 | 1999-04-01 | 2012-06-04 |
NCT00457366 | Agitation | Drug: Quetiapine|Drug: Cocktail (Haloperidol, Lorazepam, Cogentin) | University of Southern California|AstraZeneca | Phase 4 | 2006-05-01 | 2014-01-29 |
NCT00000793 | HIV Infections|Peripheral Nervous System Disease | Drug: Mexiletine hydrochloride|Drug: Benztropine mesylate|Drug: Amitriptyline hydrochloride | National Institute of Allergy and Infectious Diseases (NIAID)|Boehringer Ingelheim | Phase 2 | null | 2012-04-02 |
NCT00964886 | Back Pain | Behavioral: cognitive behavioral therapy|Drug: desipramine hydrochloride|Behavioral: cognitive behavioral therapy|Drug: benztropine mesylate 0.125 mg daily|Drug: desipramine hydrochloride | VA Office of Research and Development|University of California, San Diego | Phase 2 | 2010-01-01 | 2016-11-23 |
NCT00802100 | Schizophrenia | Drug: Olanzapine|Drug: Perphenazine|Drug: Aripiprazole|Drug: Metformin|Drug: Simvastatin|Drug: Benztropine | National Institute of Mental Health (NIMH) | Phase 4 | 2008-12-01 | 2013-01-03 |
NCT00167856 | Neuropathic Pain|Pain|Spinal Cord Injuries | Drug: Venalafaxine hydrochloride | VA Office of Research and Development | 2005-06-01 | 2014-03-26 | |
NCT00009672 | Radiculopathy|Sciatica | Drug: Nortriptyline|Drug: Morphine | National Institute of Dental and Craniofacial Research (NIDCR)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2001-01-30 | 2017-01-24 |
NCT01833897 | Bipolar Disorder | Drug: Standard of Care|Drug: Ketamine|Drug: D-cycloserine | New York State Psychiatric Institute | Phase 4 | 2013-03-01 | 2016-04-25 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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