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Bimatoprost

比马前列腺素,贝美前列素, AGN 192024

Bimatoprost是前列腺素类似物，可作用于眼内高压和青光眼。

目录号
EY0714
EY0714
EY0714
EY0714
纯度
99.52%
99.52%
99.52%
99.52%
规格
1 mg
5 mg
10 mg
50 mg
原价
330
840
1390
4300
售价
330
840
1390
4300
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Brubaker RF, et al. Surv Ophthalmol, 2001, 45 Suppl 4, S347-351.
    [2] Maxey, Kirk M., et al., 2002. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of ophthalmology. 47 Suppl 1: S34-40.
    [3] Woodward, D F., et al., 2001. The pharmacology of bimatoprost (Lumigan). Survey of ophthalmology. 45 Suppl 4(): S337-45.
    [4] Lake, S., et al., 1994. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS letters. 355(3): 317-25.

    分子式
    C25H37NO4    		 分子量
    415.57    		 CAS号
    155206-00-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    25 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01387906 Hypotrichosis Drug: topical bimatoprost Kenneth Beer|Allergan|Beer, Kenneth R., M.D., PA Phase 4 2011-03-01 2012-06-14
    NCT00773136 Hypertrichosis Drug: Bimatoprost Suspension University of Miami 2008-02-01 2014-03-20
    NCT01271686 Intraocular Pressure|Glaucoma|Ocular Hypertension Drug: 0.01% bimatoprost University of California, San Diego Phase 4 2011-01-01 2014-05-19
    NCT02444767 Healthy Volunteers Drug: 13mg Bimatoprost Ocular Insert ForSight Vision5, Inc. Phase 1 2015-03-01 2015-05-13
    NCT02830776 Dermatochalasis Drug: bimatoprost 0.03% ophthalmic solution Tulane University|Allergan Early Phase 1 2016-11-01 2016-12-07
    NCT01391273 Eyelash Hypotrichosis Drug: bimatoprost solution 0.03%|Drug: bimatoprost vehicle solution Allergan Phase 3 2011-07-01 2013-05-21
    NCT01391286 Eyelash Hypotrichosis Drug: bimatoprost solution 0.03%|Drug: bimatoprost vehicle solution Allergan Phase 3 2011-07-01 2013-05-21
    NCT00187577 Alopecia Areata Drug: Latanoprost (Xalatan)|Drug: Bimatoprost (Lumigan)|Drug: Topical application of latanoprost solution to eyelid University of California, San Francisco 2005-06-01 2011-06-07
    NCT02537015 Primary Open-Angle Glaucoma|Ocular Hypertension Drug: Bimatoprost Ocular Insert ForSight Vision5, Inc. Phase 1|Phase 2 2015-08-01 2017-02-15
    NCT02676310 Alopecia|Alopecia, Androgenetic|Baldness Drug: Bimatoprost Allergan Phase 1 2016-03-01 2017-03-15
    NCT01200251 Madarosis|Hypotrichosis Drug: Bimatoprost eyelash gel Duke University Phase 3 2007-02-01 2014-07-14
    NCT01298700 Glaucoma|Ocular Hypertension Drug: bimatoprost 0.01% ophthalmic solution|Drug: bimatoprost 0.03% ophthalmic solution Allergan Phase 4 2011-04-01 2016-12-08
    NCT01623479 Eyelash Hypotrichosis Drug: bimatoprost 0.03% Allergan 2010-11-01 2012-08-16
    NCT01646151 Glaucoma, Open-Angle|Ocular Hypertension Drug: Bimatoprost Allergan 2012-05-01 2014-05-15
    NCT02061683 Glaucoma, Open-Angle|Ocular Hypertension Drug: Bimatoprost 0.03% Allergan Phase 4 2010-04-01 2014-05-19
    NCT00567788 Glaucoma, Angle-Closure Drug: Latanoprost-Bimatoprost|Drug: Bimatoporost-Latanoprost Singapore National Eye Centre|Allergan 2006-07-01 2007-12-04
    NCT02020512 Glaucoma, Open-Angle|Ocular Hypertension Drug: 0.03% Bimatoprost Allergan Phase 4 2011-07-01 2014-06-24
    NCT02170662 Male Pattern Hair Loss|Androgenetic Alopecia Drug: Bimatoprost|Drug: Placebo Duke University Phase 2 2009-11-01 2014-08-27
    NCT01830140 Glaucoma|Ocular Hypertension Drug: Bimatoprost 0.01%|Drug: Bimatoprost 0.03% Allergan Phase 3 2013-07-01 2015-04-21
    NCT00941096 Glaucoma|Ocular Hypertension Drug: Bimatoprost and Bimatoprost/Timolol fixed combination. Larissa University Hospital Phase 4 2009-07-01 2010-11-29

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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