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生物活性
Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Briejer MR, et al. Eur J Pharmacol, 2001, 423(1), 71-83.
[2] Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3):681-91.
分子式
C22H32ClN3O7 |
分子量
485.96 |
CAS号
179474-85-2 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
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DMSO
100 mg/mL |
Water
100 mg/mL |
Ethanol
<1 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
| NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
| NCT01807000 | Healthy | Drug: Radiolabeled Prucalopride Succinate | Shire | Phase 1 | 2013-03-01 | 2014-08-22 |
| NCT02047045 | Constipation | Procedure: acupuncture|Drug: Prucalopride | Guang'anmen Hospital of China Academy of Chinese Medical Sciences|Ministry of Science and Technology of the People麓s Republic of China | 2014-04-01 | 2016-10-05 |
| NCT01870674 | Healthy | Drug: YH12852|Drug: Prucalopride|Drug: Placebo | Yuhan Corporation | Phase 1 | 2013-08-01 | 2015-05-07 |
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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