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Indapamide

吲达帕胺

Indapamide可作用于钾离子通道,是非噻嗪类磺胺类利尿剂。

目录号
EY0698
EY0698
EY0698
EY0698
纯度
99.19%
99.19%
99.19%
99.19%
规格
100 mg
500 mg
1 g
5 g
原价
130
380
485
790
售价
130
380
485
790
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Campbell, D B., et al., 1990. Cardiovascular protective properties of indapamide. The American journal of cardiology. 65(17): 11H-27H.

    分子式
    C16H16ClN3O3S
    分子量
    365.83
    CAS号
    26807-65-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    72 mg/mL
    Water
    <1 mg/mL
    Ethanol
    72 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01172431 Hypertension|Renal Insufficiency Drug: Indapamide|Drug: Hydrochlorothiazide West China Hospital Phase 4 2010-09-01 2014-06-23
    NCT00980187 Hypertension|Type 2 Diabetes Mellitus Drug: Hydrochlorothiazide|Drug: Indapamide LaborMed Pharma S.A. Phase 4 2008-03-01 2011-06-14
    NCT01620788 Hypertension Drug: Indapamide / Losartan|Drug: Indapamide / Losartan|Drug: Hyzaar庐|Drug: Hyzaar庐 EMS Phase 3 2017-05-01 2017-01-26
    NCT02655029 Adherence to Medication Regime|Hypertensive Disease Drug: Perindopril/Indapamide/Amlodipine fixed dose combination Servier Hellas Pharmaceuticals Ltd. 2015-11-25 2017-03-23
    NCT02710539 Arterial Hypertension Drug: perindopril, indapamide , amlodipine|Drug: Tripliam (perindopril, indapamide, amlodipine) University of Roma La Sapienza Phase 4 2016-04-01 2016-03-15
    NCT02710552 Arterial Hypertension Drug: Tripliam (perindopril, indapamide, amlodipine)|Drug: Reaptan (perindopril, amlodipine) University of Roma La Sapienza Phase 4 2016-04-01 2016-03-16
    NCT00145925 Diabetes Mellitus, Type 2 Drug: Perindopril-indapamide|Drug: Gliclazide MR-based glucose lowering The George Institute|Institut de Recherches Internationales Servier|University of Sydney|National Health and Medical Research Council, Australia Phase 3 2001-06-01 2008-09-16
    NCT00122811 Hypertension Drug: Indapamide SR 1.5mg; Perindopril 2-4mg Imperial College London|British Heart Foundation|Institut de Recherches Internationales Servier Phase 4 2000-11-01 2007-08-20
    NCT02699645 Acute Intracerebral Haemorrhage (ICH) Drug: telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg|Drug: Placebo The George Institute Phase 4 2017-05-01 2017-01-30
    NCT01500590 Diabetes|Hypertensive Disease Drug: Renin-angiotensin system blockers|Drug: non-renin angiotensin system blockers Hospital Authority, Hong Kong Phase 4 2011-11-01 2016-09-02
    NCT00128518 Hypertension Drug: Indapamide (T2)|Drug: Perindopril (T1)|Drug: Placebo of Perindopril (P1)|Drug: Placebo of Indapamide (P2) Hospices Civils de Lyon Phase 4 2004-10-01 2011-12-29
    NCT00949286 Diabetes Mellitus, Type 2 The George Institute|Servier 2010-01-01 2014-05-15
    NCT01754779 Calcium Phosphate Kidney Stones Drug: Placebo|Dietary Supplement: Citric Acid|Dietary Supplement: Potassium Citrate|Drug: Indapamide University of Texas Southwestern Medical Center|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2 2012-07-01 2016-10-27
    NCT01964079 Hypertension Drug: Amlodipine|Drug: Losartan Wonju Severance Christian Hospital|Pfizer Phase 4 2013-04-01 2016-04-29
    NCT00398541 Hypertension Drug: losartan potassium (+) hydrochlorothiazide Merck Sharp & Dohme Corp. Phase 3 2005-03-01 2015-09-23
    NCT00664846 Stroke Drug: Aspirin / Clopidogrel, Atorvastatin / Simvastatin|Drug: Asprin / Clopidogrel, Atorvastatin / Simvastatin Peking Union Medical College Hospital 2008-04-01 2011-04-08
    NCT00691314 Stroke|Transient Ischemic Attack|Atherosclerosis|Stenosis|Stents Device: Stent implantation (Wingspan, Coroflex, and TiTAN2)|Drug: Standard medical treatment Peking Union Medical College Hospital 2008-06-01 2011-02-23
    NCT00684489 Hypertension Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. Medical University of South Carolina|New York Presbyterian Hospital 2003-09-01 2008-05-22
    NCT01961323 Hypertension|Left Ventricular Diastolic Dysfunction Drug: Nebivolol Icahn School of Medicine at Mount Sinai|Forest Laboratories Phase 4 2012-03-01 2016-06-22
    NCT02364089 Adrenal Incidentalomas Procedure: Laparoscopic surgical removal of the adrenal tumor|Drug: Standardized medical treatment of hypertension by SAHR University Hospital, Bordeaux 2015-01-01 2015-02-13
    NCT01588795 Diabetic Nephropathy|Persistent Proteinuria With Type II Diabetes Procedure: Percutaneous renal denervation and TMNS|Drug: Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin Assistance Publique - H么pitaux de Paris Phase 4 2012-04-01 2016-05-30
    NCT00670787 Hypertension Drug: Combination pill of losartan and hydrochlorothiazide Kyushu University Phase 3 2008-06-01 2011-03-04
    NCT02539810 Hypertension|Hypertension Resistant to Conventional Therapy|Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) 鈮?60% Device: Renal artery Angioplasty plus stenting.|Drug: Anti hypertensive, statin and antiplatelet medication. Assistance Publique - H么pitaux de Paris|Ministry of Health, France Phase 4 2015-09-01 2016-02-23
    NCT01996085 Arterial Hypertension Drug: lisinopril|Drug: Telmisartan|Drug: Nebivolol|Drug: Indapamide/hydrochlorothiazide|Drug: Amlodipine|Drug: lisinopril|Drug: Telmisartan|Drug: Nebivolol|Drug: Indapamide/hydrochlorothiazide|Drug: Amlodipine Military Institute of Medicine, Poland 2013-01-01 2015-04-06
    NCT00295542 Hypertension Device: Ambulatory blood pressure monitoring|Procedure: Chronotherapy, timing of antihypertensive medication|Drug: ACEI (including spirapril, enalapril, quinapril, lisinopril)|Drug: ARB (including valsartan, telmisartan, olmesartan)|Drug: beta blockers (including nebivolol, atenolol, carvedilol)|Drug: diuretics (torasemide, indapamide, HTCZ) and doxazosin|Procedure: Combination therapy in essential hypertension University of Vigo|Hospital Clinico Universitario de Santiago|Xunta de Galicia|Ministerio de Educacion y Ciencia, Spain Phase 4 2000-03-01 2009-04-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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