Indapamide可作用于钾离子通道,是非噻嗪类磺胺类利尿剂。
Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Campbell, D B., et al., 1990. Cardiovascular protective properties of indapamide. The American journal of cardiology. 65(17): 11H-27H.
分子式 C16H16ClN3O3S |
分子量 365.83 |
CAS号 26807-65-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 72 mg/mL |
Water <1 mg/mL |
Ethanol 72 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01172431 | Hypertension|Renal Insufficiency | Drug: Indapamide|Drug: Hydrochlorothiazide | West China Hospital | Phase 4 | 2010-09-01 | 2014-06-23 |
NCT00980187 | Hypertension|Type 2 Diabetes Mellitus | Drug: Hydrochlorothiazide|Drug: Indapamide | LaborMed Pharma S.A. | Phase 4 | 2008-03-01 | 2011-06-14 |
NCT01620788 | Hypertension | Drug: Indapamide / Losartan|Drug: Indapamide / Losartan|Drug: Hyzaar庐|Drug: Hyzaar庐 | EMS | Phase 3 | 2017-05-01 | 2017-01-26 |
NCT02655029 | Adherence to Medication Regime|Hypertensive Disease | Drug: Perindopril/Indapamide/Amlodipine fixed dose combination | Servier Hellas Pharmaceuticals Ltd. | 2015-11-25 | 2017-03-23 | |
NCT02710539 | Arterial Hypertension | Drug: perindopril, indapamide , amlodipine|Drug: Tripliam (perindopril, indapamide, amlodipine) | University of Roma La Sapienza | Phase 4 | 2016-04-01 | 2016-03-15 |
NCT02710552 | Arterial Hypertension | Drug: Tripliam (perindopril, indapamide, amlodipine)|Drug: Reaptan (perindopril, amlodipine) | University of Roma La Sapienza | Phase 4 | 2016-04-01 | 2016-03-16 |
NCT00145925 | Diabetes Mellitus, Type 2 | Drug: Perindopril-indapamide|Drug: Gliclazide MR-based glucose lowering | The George Institute|Institut de Recherches Internationales Servier|University of Sydney|National Health and Medical Research Council, Australia | Phase 3 | 2001-06-01 | 2008-09-16 |
NCT00122811 | Hypertension | Drug: Indapamide SR 1.5mg; Perindopril 2-4mg | Imperial College London|British Heart Foundation|Institut de Recherches Internationales Servier | Phase 4 | 2000-11-01 | 2007-08-20 |
NCT02699645 | Acute Intracerebral Haemorrhage (ICH) | Drug: telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg|Drug: Placebo | The George Institute | Phase 4 | 2017-05-01 | 2017-01-30 |
NCT01500590 | Diabetes|Hypertensive Disease | Drug: Renin-angiotensin system blockers|Drug: non-renin angiotensin system blockers | Hospital Authority, Hong Kong | Phase 4 | 2011-11-01 | 2016-09-02 |
NCT00128518 | Hypertension | Drug: Indapamide (T2)|Drug: Perindopril (T1)|Drug: Placebo of Perindopril (P1)|Drug: Placebo of Indapamide (P2) | Hospices Civils de Lyon | Phase 4 | 2004-10-01 | 2011-12-29 |
NCT00949286 | Diabetes Mellitus, Type 2 | The George Institute|Servier | 2010-01-01 | 2014-05-15 | ||
NCT01754779 | Calcium Phosphate Kidney Stones | Drug: Placebo|Dietary Supplement: Citric Acid|Dietary Supplement: Potassium Citrate|Drug: Indapamide | University of Texas Southwestern Medical Center|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 2 | 2012-07-01 | 2016-10-27 |
NCT01964079 | Hypertension | Drug: Amlodipine|Drug: Losartan | Wonju Severance Christian Hospital|Pfizer | Phase 4 | 2013-04-01 | 2016-04-29 |
NCT00398541 | Hypertension | Drug: losartan potassium (+) hydrochlorothiazide | Merck Sharp & Dohme Corp. | Phase 3 | 2005-03-01 | 2015-09-23 |
NCT00664846 | Stroke | Drug: Aspirin / Clopidogrel, Atorvastatin / Simvastatin|Drug: Asprin / Clopidogrel, Atorvastatin / Simvastatin | Peking Union Medical College Hospital | 2008-04-01 | 2011-04-08 | |
NCT00691314 | Stroke|Transient Ischemic Attack|Atherosclerosis|Stenosis|Stents | Device: Stent implantation (Wingspan, Coroflex, and TiTAN2)|Drug: Standard medical treatment | Peking Union Medical College Hospital | 2008-06-01 | 2011-02-23 | |
NCT00684489 | Hypertension | Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. | Medical University of South Carolina|New York Presbyterian Hospital | 2003-09-01 | 2008-05-22 | |
NCT01961323 | Hypertension|Left Ventricular Diastolic Dysfunction | Drug: Nebivolol | Icahn School of Medicine at Mount Sinai|Forest Laboratories | Phase 4 | 2012-03-01 | 2016-06-22 |
NCT02364089 | Adrenal Incidentalomas | Procedure: Laparoscopic surgical removal of the adrenal tumor|Drug: Standardized medical treatment of hypertension by SAHR | University Hospital, Bordeaux | 2015-01-01 | 2015-02-13 | |
NCT01588795 | Diabetic Nephropathy|Persistent Proteinuria With Type II Diabetes | Procedure: Percutaneous renal denervation and TMNS|Drug: Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin | Assistance Publique - H么pitaux de Paris | Phase 4 | 2012-04-01 | 2016-05-30 |
NCT00670787 | Hypertension | Drug: Combination pill of losartan and hydrochlorothiazide | Kyushu University | Phase 3 | 2008-06-01 | 2011-03-04 |
NCT02539810 | Hypertension|Hypertension Resistant to Conventional Therapy|Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) 鈮?60% | Device: Renal artery Angioplasty plus stenting.|Drug: Anti hypertensive, statin and antiplatelet medication. | Assistance Publique - H么pitaux de Paris|Ministry of Health, France | Phase 4 | 2015-09-01 | 2016-02-23 |
NCT01996085 | Arterial Hypertension | Drug: lisinopril|Drug: Telmisartan|Drug: Nebivolol|Drug: Indapamide/hydrochlorothiazide|Drug: Amlodipine|Drug: lisinopril|Drug: Telmisartan|Drug: Nebivolol|Drug: Indapamide/hydrochlorothiazide|Drug: Amlodipine | Military Institute of Medicine, Poland | 2013-01-01 | 2015-04-06 | |
NCT00295542 | Hypertension | Device: Ambulatory blood pressure monitoring|Procedure: Chronotherapy, timing of antihypertensive medication|Drug: ACEI (including spirapril, enalapril, quinapril, lisinopril)|Drug: ARB (including valsartan, telmisartan, olmesartan)|Drug: beta blockers (including nebivolol, atenolol, carvedilol)|Drug: diuretics (torasemide, indapamide, HTCZ) and doxazosin|Procedure: Combination therapy in essential hypertension | University of Vigo|Hospital Clinico Universitario de Santiago|Xunta de Galicia|Ministerio de Educacion y Ciencia, Spain | Phase 4 | 2000-03-01 | 2009-04-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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