Terbinafine盐酸盐是抗真菌化合物,可杀灭皮肤癣菌和双相型真菌,抑制白色念珠菌。
Terbinafine HCl inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Vickers AE, et al. Drug Metab Dispos, 1999, 27(9), 1029-1038.
[2] Motavaze, K., et al. 2008. Iran. Biomed. J. 12: 55-58.
[3] Sander, C.S., et al. 2002. Mycoses. 45: 152-155.
[4] Favre, B., et al. 1997. Arch. Biochem. Biophys. 340: 265-269.
分子式 C21H26ClN |
分子量 327.89 |
CAS号 78628-80-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 10 mg/mL |
Water Insoluble |
Ethanol 30 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00833586 | Healthy | Drug: Terbinafine HCl 250mg tablets|Drug: Lamisil庐 250 mg Tablets | Teva Pharmaceuticals USA | Phase 1 | 2002-01-01 | 2009-09-11 |
NCT00691184 | Onychomycosis/Onycholysis and Tinea Pedis | Drug: Placebo|Drug: Terbinafine Hydrochloride|Drug: Terbinafine Hydrochloride|Drug: Terbinafine | NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.) | Phase 1 | 2005-02-01 | 2008-06-03 |
NCT00833664 | Healthy | Drug: Terbinafine HCl 250mg tablets|Drug: Lamisil庐 250 mg Tablets | Teva Pharmaceuticals USA | Phase 1 | 2002-01-01 | 2009-09-11 |
NCT01484145 | Onychomycosis | Drug: Terbinafine HCl | Nitric BioTherapeutics, Inc | Phase 2 | 2011-12-01 | 2012-10-18 |
NCT01286701 | Healthy | Drug: Terbinafine Hydrochloride Tablets, 250 mg | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-01-01 | 2012-01-10 |
NCT01286688 | Fasting | Drug: Terbinafine Hydrochloride Tablets, 250 mg | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-01-01 | 2012-01-10 |
NCT00117767 | Tinea Capitis | Drug: Terbinafine hydrochloride (HCl)|Drug: Griseofulvin | Novartis Pharmaceuticals|Novartis | Phase 3 | 2004-06-01 | 2017-03-17 |
NCT01790165 | Onychomycosis | Drug: TDT067 and Lamisil | Celtic Pharma Development Services|PPD | Phase 2 | 2009-12-01 | 2013-02-11 |
NCT00459537 | Onychomycosis | Drug: terbinafine hydrogen chloride|Drug: amorolfine nail lacquer | Novartis | Phase 3 | 2007-03-01 | 2011-05-03 |
NCT01772212 | Mycoses | Drug: Terbinafine 250 mg|Drug: Terbinafine 250 mg | GlaxoSmithKline | Phase 1 | 2011-02-01 | 2013-01-17 |
NCT00768768 | Onychomycosis | Other: Electrokinetic Transungual System (ETS) - Terbinafine Gel|Other: ETS-Terbinafine Gel|Other: ETS-Terbinafine Gel|Other: ETS-Terbinafine Gel|Other: ETS-Terbinafine Gel | Transport Pharmaceuticals | Phase 1 | 2008-10-01 | 2009-03-10 |
NCT01615913 | Onychomycosis | Drug: 3 mg terbinafine and 2 mg ketoconazole containing patch|Drug: 6 mg terbinafine and 2 mg ketoconazole containing patch|Drug: 8 mg terbinafine and 2 mg ketoconazole containing patch | Taiwan Biotech Co., Ltd. | Phase 1 | 2012-04-01 | 2012-06-06 |
NCT00117754 | Tinea Capitis | Drug: Terbinafine hydrochloride | Novartis | Phase 3 | 2004-07-01 | 2007-02-20 |
NCT00443820 | Onychomycosis | Drug: terbinafine|Drug: Placebo|Drug: terbinafine|Drug: Placebo | Novartis Pharmaceuticals|Novartis | Phase 3 | 2006-12-01 | 2011-03-22 |
NCT00443898 | Onychomycosis | Drug: terbinafine|Drug: Placebo|Drug: terbinafine|Drug: Placebo | Novartis Pharmaceuticals|Novartis | Phase 3 | 2006-12-01 | 2012-05-01 |
NCT01851590 | Onychomycosis | Device: Resin Lacquer|Drug: Amorolfine|Drug: Terbinafine | Helsinki University Central Hospital|Repolar Ltd. | Phase 4 | 2013-10-01 | 2015-10-24 |
NCT01433107 | Tinea Pedis | Drug: Terbinafine|Drug: Terbinafine Placebo | Novartis | Phase 3 | 2011-08-01 | 2013-12-03 |
NCT01080079 | Onychomycosis | Drug: Terbinafine Hydrochloride|Other: Purified Water | Nitric BioTherapeutics, Inc | Phase 2 | 2010-05-01 | 2012-10-18 |
NCT01145807 | Onychomycosis | Drug: TDT067|Drug: Placebo|Drug: Transfersome | Celtic Pharma Development Services|PPD | Phase 3 | 2010-04-01 | 2012-07-31 |
NCT00648713 | Healthy | Drug: Terbinafine Hydrochloride Tablets 250 mg|Drug: Lamisil庐 Tablets 250 mg | Mylan Pharmaceuticals | Phase 1 | 2004-02-01 | 2008-03-31 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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