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Terbinafine HCl

盐酸特比萘芬,KWD 2019,KWD2019,KWD-2019

Terbinafine盐酸盐是抗真菌化合物,可杀灭皮肤癣菌和双相型真菌,抑制白色念珠菌。

目录号
EY0682
EY0682
纯度
99.31%
99.31%
规格
100 mg
200 mg
原价
475
860
售价
475
860
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Terbinafine HCl inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Vickers AE, et al. Drug Metab Dispos, 1999, 27(9), 1029-1038.
    [2] Motavaze, K., et al. 2008. Iran. Biomed. J. 12: 55-58.
    [3] Sander, C.S., et al. 2002. Mycoses. 45: 152-155.
    [4] Favre, B., et al. 1997. Arch. Biochem. Biophys. 340: 265-269.

    分子式
    C21H26ClN
    分子量
    327.89
    CAS号
    78628-80-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    10 mg/mL
    Water
    Insoluble
    Ethanol
    30 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00833586 Healthy Drug: Terbinafine HCl 250mg tablets|Drug: Lamisil庐 250 mg Tablets Teva Pharmaceuticals USA Phase 1 2002-01-01 2009-09-11
    NCT00691184 Onychomycosis/Onycholysis and Tinea Pedis Drug: Placebo|Drug: Terbinafine Hydrochloride|Drug: Terbinafine Hydrochloride|Drug: Terbinafine NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.) Phase 1 2005-02-01 2008-06-03
    NCT00833664 Healthy Drug: Terbinafine HCl 250mg tablets|Drug: Lamisil庐 250 mg Tablets Teva Pharmaceuticals USA Phase 1 2002-01-01 2009-09-11
    NCT01484145 Onychomycosis Drug: Terbinafine HCl Nitric BioTherapeutics, Inc Phase 2 2011-12-01 2012-10-18
    NCT01286701 Healthy Drug: Terbinafine Hydrochloride Tablets, 250 mg Dr. Reddy's Laboratories Limited Phase 1 2002-01-01 2012-01-10
    NCT01286688 Fasting Drug: Terbinafine Hydrochloride Tablets, 250 mg Dr. Reddy's Laboratories Limited Phase 1 2002-01-01 2012-01-10
    NCT00117767 Tinea Capitis Drug: Terbinafine hydrochloride (HCl)|Drug: Griseofulvin Novartis Pharmaceuticals|Novartis Phase 3 2004-06-01 2017-03-17
    NCT01790165 Onychomycosis Drug: TDT067 and Lamisil Celtic Pharma Development Services|PPD Phase 2 2009-12-01 2013-02-11
    NCT00459537 Onychomycosis Drug: terbinafine hydrogen chloride|Drug: amorolfine nail lacquer Novartis Phase 3 2007-03-01 2011-05-03
    NCT01772212 Mycoses Drug: Terbinafine 250 mg|Drug: Terbinafine 250 mg GlaxoSmithKline Phase 1 2011-02-01 2013-01-17
    NCT00768768 Onychomycosis Other: Electrokinetic Transungual System (ETS) - Terbinafine Gel|Other: ETS-Terbinafine Gel|Other: ETS-Terbinafine Gel|Other: ETS-Terbinafine Gel|Other: ETS-Terbinafine Gel Transport Pharmaceuticals Phase 1 2008-10-01 2009-03-10
    NCT01615913 Onychomycosis Drug: 3 mg terbinafine and 2 mg ketoconazole containing patch|Drug: 6 mg terbinafine and 2 mg ketoconazole containing patch|Drug: 8 mg terbinafine and 2 mg ketoconazole containing patch Taiwan Biotech Co., Ltd. Phase 1 2012-04-01 2012-06-06
    NCT00117754 Tinea Capitis Drug: Terbinafine hydrochloride Novartis Phase 3 2004-07-01 2007-02-20
    NCT00443820 Onychomycosis Drug: terbinafine|Drug: Placebo|Drug: terbinafine|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2006-12-01 2011-03-22
    NCT00443898 Onychomycosis Drug: terbinafine|Drug: Placebo|Drug: terbinafine|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2006-12-01 2012-05-01
    NCT01851590 Onychomycosis Device: Resin Lacquer|Drug: Amorolfine|Drug: Terbinafine Helsinki University Central Hospital|Repolar Ltd. Phase 4 2013-10-01 2015-10-24
    NCT01433107 Tinea Pedis Drug: Terbinafine|Drug: Terbinafine Placebo Novartis Phase 3 2011-08-01 2013-12-03
    NCT01080079 Onychomycosis Drug: Terbinafine Hydrochloride|Other: Purified Water Nitric BioTherapeutics, Inc Phase 2 2010-05-01 2012-10-18
    NCT01145807 Onychomycosis Drug: TDT067|Drug: Placebo|Drug: Transfersome Celtic Pharma Development Services|PPD Phase 3 2010-04-01 2012-07-31
    NCT00648713 Healthy Drug: Terbinafine Hydrochloride Tablets 250 mg|Drug: Lamisil庐 Tablets 250 mg Mylan Pharmaceuticals Phase 1 2004-02-01 2008-03-31

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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