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Metoprolol Tartrate

酒石酸美托洛尔,CGP 2175E,Lopressor

Metoprolol是心脏选择性β1肾上腺素阻断剂。

目录号
EY0661
EY0661
EY0661
纯度
99.76%
99.76%
99.76%
规格
5 mg
10 mg
50 mg
原价
210
340
1100
售价
210
340
1100
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Sabbah HN, et al. J Am Coll Cardiol,?000, 36(5), 1698-1705.
    [2] Prakash, A. and Markham, A. 2000. Drugs. 60: 647-678.
    [3] Brynne, L., et al. 1998. J. Pharmacol. Exp. Ther. 286: 1152-1158.
    [4] Olbrich, A., et al. 1999. J. Cardiovasc. Pharmacol. 33: 193-203.

    分子式
    C34H56N2O12    		 分子量
    684.81    		 CAS号
    56392-17-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    31 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT03082352 Healthy Drug: BF-Metoprolol Tablet 100mg|Drug: Betaloc Tablet 100mg Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited|Chinese University of Hong Kong Phase 1 2017-04-01 2017-03-12
    NCT01728272 Drug Absorption Drug: blood concentration of metoprolol Kuopio University Hospital 2012-11-01 2015-08-19
    NCT00999102 Hypertension Drug: Metoprolol|Drug: Nebivolol Weill Medical College of Cornell University|Forest Laboratories Phase 4 2009-10-01 2012-03-16
    NCT01902550 Healthy Drug: Metoprolol tartrate immediate-release (metoprolol IR)|Drug: JNJ-54452840|Drug: Placebo Janssen Research & Development, LLC Phase 1 2013-07-01 2016-10-31
    NCT01673997 Healthy Drug: Metoprolol Succinate Dr. Reddy's Laboratories Limited Phase 1 2010-12-01 2012-09-24
    NCT01659944 Healthy Drug: Eliglustat|Drug: Metoprolol Genzyme, a Sanofi Company|Sanofi Phase 1 2012-05-01 2015-03-19
    NCT00649116 Healthy Drug: Metoprolol Tartrate Tablets 100 mg|Drug: Lopressor庐 Tablets 100 mg Mylan Pharmaceuticals Phase 1 2002-12-01 2008-03-31
    NCT00648271 Healthy Drug: Metoprolol Tartrate Tablets 25 mg|Drug: Lopressor庐 Tablets 50 mg Mylan Pharmaceuticals Phase 1 2002-12-01 2008-03-31
    NCT00992056 Hypertension Drug: nebivolol|Drug: Metoprolol University of Miami|Forest Laboratories Phase 4 2010-12-01 2014-05-20
    NCT00861016 Hypertension Drug: metoprolol succinate prolonged-release tablet and felodipine AstraZeneca Phase 4 2005-10-01 2009-03-12
    NCT01694797 Healthy Drug: Metoprolol Succinate Dr. Reddy's Laboratories Limited Phase 1 2011-01-01 2012-09-27
    NCT00649233 Healthy Drug: Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg|Drug: Lopressor HCT庐 Tablets 100/50 mg Mylan Pharmaceuticals Phase 1 2003-01-01 2008-03-31
    NCT00649688 Healthy Drug: Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg|Drug: Lopressor HCT庐 Tablets 100/50 mg Mylan Pharmaceuticals Phase 1 2003-01-01 2008-03-31
    NCT02269696 Breast Cancer Drug: Metoprolol|Drug: Normal saline Kuopio University Hospital Phase 3 2017-10-01 2016-11-01
    NCT00995072 Hypertension|Female Sexual Dysfunction Drug: nebivolol and metoprolol succinate|Drug: metoprolol succinate and nebivolol East Coast Institute for Research 2009-10-01 2012-08-13
    NCT02251509 Atrial Fibrillation Drug: Carvedilol|Drug: Metoprolol tartrate Creighton University Phase 4 2016-12-01 2016-06-15
    NCT01755663 Coronary Artery Disease Drug: Ivabradine and Metoprolol Col. Suthee Panichkul|Phramongkutklao College of Medicine and Hospital Phase 4 2014-12-01 2014-10-27
    NCT02025465 Atrial Fibrillation|Atrial Flutter Drug: Metoprolol|Drug: Diltiazem CAMC Health System Phase 4 2013-12-01 2016-01-28
    NCT00849810 Hypertension Drug: Metoprolol|Drug: Nebivolol University of Mississippi Medical Center 2009-01-01 2013-03-18
    NCT02123056 Vasovagal Syncope Drug: Metoprolol|Drug: Matching Placebo University of Calgary|Vanderbilt University Phase 4 2014-10-01 2016-08-29
    NCT01523054 Acute Myocardial Infarction Drug: Metoprolol- Toprol XL|Drug: Metoprolol- Lopressor AstraZeneca Phase 1 2000-02-01 2012-01-30
    NCT02924454 Drug Overdose|Overdose of Beta-adrenergic Blocking Drug|Blood Pressure Drug: metoprolol|Drug: intravenous lipid emulsion|Drug: Sodium chloride 0.9% solution - lipid emulsion dummy|Drug: Sodium chloride 0.9% solution - metoprolol dummy Mikkel Bring Christensen|University Hospital Bispebjerg and Frederiksberg Phase 4 2016-09-01 2016-10-03
    NCT00783900 Atrial Fibrillation|Biatrial Pacing|Metoprolol Other: metoprolol, biatrial pacing Kuopio University Hospital|Oulu University Hospital|Hospital Cordia, Kuopio, Finland Phase 4 2007-01-01 2017-03-01

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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