Home > Aromatase & > Anastrozole

Anastrozole

阿那曲唑,阿纳托唑,阿纳曲唑,ZD 1033,ZD1033,ZD-1033,

Anastrozole(ZD1033) 是选择性CYP19抑制剂，IC50为15 nM，对肾上腺皮质素合成无影响。

目录号
EY0642
EY0642
EY0642
EY0642
纯度
99.58%
99.58%
99.58%
99.58%
规格
5 mg
10 mg
100 mg
500 mg
原价
280
430
1200
3000
售价
280
430
1200
3000
库存
现货
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Dukes M, et al. J Steroid Biochem Mol Biol, 1996, 58(4), 439-445.
    [2] Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994)
    [3] Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

    分子式
    C17H19N5    		 分子量
    293.37    		 CAS号
    120511-73-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    59 mg/mL     		Water
    <1 mg/mL    		 Ethanol
    59 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00301457 Breast Cancer Drug: Anastrozole Maastricht University Medical Center Phase 3 2006-06-01 2017-02-14
    NCT00638391 Breast Cancer Drug: Anastrozole AstraZeneca 2005-05-01 2008-03-19
    NCT01155960 Healthy Drug: Anastrozole Dr. Reddy's Laboratories Limited Phase 1 2008-05-01 2010-07-01
    NCT01155947 Healthy Drug: Anastrozole Dr. Reddy's Laboratories Limited Phase 1 2008-05-01 2010-07-01
    NCT01183390 Healthy Drug: Anastrozole|Drug: Anastrozole Teva Pharmaceuticals USA Phase 1 2005-09-01 2010-10-15
    NCT01182181 Healthy Drug: Anastrozole (Teva Pharmaceuticals USA)|Drug: Anastrozole (Arimidex庐) Teva Pharmaceuticals USA Phase 1 2005-08-01 2010-10-15
    NCT00421447 Breast Cancer Drug: Anastrozole Hamilton Health Sciences Corporation|Canadian Institutes of Health Research (CIHR)|McMaster University 2007-01-01 2015-09-22
    NCT02140437 Carcinoma Breast Stage IV Drug: Fulvestrant|Drug: Anastrozole Fudan University Phase 2 2014-03-01 2015-12-24
    NCT00244959 Breast Cancer Drug: anastrozole|Procedure: adjuvant therapy Sidney Kimmel Comprehensive Cancer Center|National Cancer Institute (NCI) Phase 2 2004-01-01 2013-03-18
    NCT00077025 Breast Cancer Drug: Gefitinib|Drug: Anastrozole AstraZeneca Phase 2 2004-01-01 2014-07-15
    NCT00286117 Breast Cancer Drug: Anastrozole|Drug: Tamoxifen AstraZeneca|Institute of Cancer Research, United Kingdom Phase 3 1998-03-01 2009-04-30
    NCT02476955 Solid Tumors|Ovarian Cancer|Endometrial Cancer Drug: ARQ 092 + carboplatin + paclitaxel|Drug: ARQ 092 + paclitaxel|Drug: ARQ 092 + anastrozole ArQule Phase 1 2015-06-01 2017-01-17
    NCT00936442 Breast Cancer Drug: Anastrozole|Other: Educational materials AstraZeneca|Aardex Pharmionic 2009-06-01 2012-02-13
    NCT01972984 Breast Cancer Drug: Anastrozole Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation Phase 2 2012-10-01 2016-02-02
    NCT00136695 Hypogonadism Drug: anastrozole Massachusetts General Hospital|National Institute on Aging (NIA) Phase 2 2004-10-01 2016-11-30
    NCT00887380 Breast Cancer Drug: Pre-radiotherapy commencement of anastrozole|Radiation: Radiotherapy|Drug: Post radiotherapy commencement of anastrozole Trans-Tasman Radiation Oncology Group (TROG) Phase 3 2009-09-01 2017-01-22
    NCT02072512 Metastatic Breast Cancer Drug: Fulvestrant|Drug: Goserelin|Drug: Anastrozole|Drug: Goserelin Hospital Affiliated to Military Medical Science, Beijing Phase 2 2014-01-01 2014-02-24
    NCT00481845 Breast Cancer Drug: Vandetanib|Drug: Anastrozole Stanford University|AstraZeneca Phase 2 2008-01-01 2016-12-13
    NCT02730923 Endometrial Carcinoma|Metastatic Carcinoma|Hormone Receptor Positive Tumor Drug: AZD2014|Drug: Anastrozole Centre Leon Berard Phase 1|Phase 2 2016-04-01 2016-11-02
    NCT01151215 Neoplasms|Breast Neoplasms|Breast Cancer Drug: AZD8931|Drug: anastrozole|Drug: Placebo AstraZeneca Phase 2 2010-06-01 2014-07-15

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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