Piroxicam是非选择性COX抑制剂,IC50为6 mM。
Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Vartiainen N, et al. J Neurochem,2001, 76(2), 480-489.
[2] Laneuville, O., et al. 1994. J. Pharmacol. Exp. Ther. 271: 927-934.
分子式 C15H13N3O4S |
分子量 331.35 |
CAS号 36322-90-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 25 mg/mL |
Water <1 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02253446 | Primary Dysmenorrhea | Drug: Piroxicam|Drug: Diclofenac Sodium | Pamukkale University | Phase 4 | 2013-05-01 | 2014-09-27 |
NCT00670475 | Osteoarthritis of the Knee | Drug: Piroxicam|Dietary Supplement: Olive Oil | Ardabil University of Medical Sciences | Phase 2 | 2008-04-01 | 2010-04-28 |
NCT03006107 | Pulpitis - Irreversible | Procedure: intraligamentary injection piroxicam|Procedure: Intraligamentary mepevacaine | Cairo University | 2016-12-01 | 2016-12-27 | |
NCT01320709 | Contraception, Postcoital | Drug: Piroxicam ( BAYl1902)|Drug: Piroxicam ( BAYl1902)|Drug: Placebo|Drug: Piroxicam ( BAYl1902) | Bayer | Phase 2 | 2011-03-01 | 2015-07-09 |
NCT00649415 | Dysmenorrhea | Drug: piroxicam|Drug: valdecoxib | Pfizer | Phase 4 | 2003-01-01 | 2008-04-07 |
NCT02304783 | Renal Colic | Drug: Piroxicam|Drug: Placebo | University of Monastir | Phase 1|Phase 2 | 2014-01-01 | 2016-04-01 |
NCT02382653 | Neoplasm Metastases | Drug: oral perixicam | Tanta University | 2014-12-01 | 2016-05-11 | |
NCT00631514 | Hypertension | Drug: acetaminophen|Drug: ibuprofen|Drug: piroxicam | University of Split|Dr Ivancica Pavlicevic Family Practice Office | Phase 4 | 2005-01-01 | 2008-03-07 |
NCT01480752 | Post Operative Endodontic Pain | Drug: Lornoxicam|Drug: normal saline|Drug: no injection | Islamic Azad University, Tehran | Phase 2 | 2011-09-01 | 2013-01-11 |
NCT00997750 | Acute Coronary Syndrome | Drug: Lornoxicam | Central Clinical Hospital with Outpatient Health Center of Business Administration for the President of Russian Federati | Phase 4 | 2007-03-01 | 2009-10-18 |
NCT00293657 | Headache (Migraine) | Drug: Lornoxicam 8 mg|Drug: Lornoxicam 16 mg|Drug: Placebo | POZEN | Phase 2 | 2005-12-01 | 2012-11-29 |
NCT02750917 | Postoperative Pain | Drug: Lornoxicam|Drug: Etoricoxib | Foisor Orthopedics Clinical Hospital | Phase 3 | 2014-09-01 | 2016-04-25 |
NCT01564680 | Postoperative Pain | Other: placebo|Drug: Paracetamol|Drug: Lornoxicam | Dammam University | Phase 4 | 2009-03-01 | 2012-03-27 |
NCT01069055 | Inguinal Hernia|Postoperative Pain | Other: Sterile Saline|Drug: Intravenous lornoxicam|Drug: Intravenous paracetamol | Diskapi Teaching and Research Hospital | Phase 3 | 2010-02-01 | 2010-02-23 |
NCT01055470 | Osteoarthritis of Knee Joint | Drug: Diclofenac|Drug: Lornoxicam | Government Medical College, Bhavnagar | 2008-12-01 | 2010-01-22 | |
NCT00530387 | Dermatitis, Photocontact | Drug: 19 organic sunscreen filters and 5 topical NSAIDs | NHS Tayside | 2008-07-01 | 2011-08-03 | |
NCT02549118 | Analgesia|Obstetrical | Drug: Tenoxicam|Drug: Pethidine | Ain Shams Maternity Hospital | Phase 2 | 2015-09-01 | 2015-09-11 |
NCT02025166 | Pain | Drug: Paracetamol|Drug: lornoxicam | Rambam Health Care Campus | 2014-01-01 | 2013-12-30 | |
NCT01718756 | Closed Non Comminuted Long Bone Fractures | Drug: Placebo|Drug: Continuous infusion|Drug: Scheduled | Mansoura University | Phase 1|Phase 2 | 2013-06-01 | 2015-03-15 |
NCT00293631 | Bunionectomy|Orthopedic Surgery | Drug: Lornoxicam 8 mg|Drug: Lornoxicam 16 mg|Drug: Ketorolac 30 mg|Drug: Placebo | POZEN | Phase 2 | 2005-11-01 | 2012-11-29 |
NCT02191358 | Adverse Drug Events|Adverse Drug Reactions|Drug Interaction Potentiation|Drug Metabolism, Poor, CYP2D6-RELATED|Drug Metabolism, Poor, CYP2C19-RELATED|Cytochrome P450 Enzyme Deficiency|Cytochrome P450 CYP2D6 Enzyme Deficiency|Cytochrome P450 CYP2C9 Enzyme Deficiency|Cytochrome P450 CYP2C19 Enzyme Deficiency|Cytochrome P450 CYP3A Enzyme Deficiency|Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant|Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant|Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant | Genelex Corporation|University of Utah | 2014-10-01 | 2017-02-27 | ||
NCT03038321 | Non-Muscle-invasive Bladder Cancer (NMIBC)|Bacillus Calmette-Guerin (BCG) Cystitis|Intra-vesical Instillation | Drug: sofenacin|Drug: Tavanic|Drug: Xefo | Mansoura University | Phase 4 | 2017-02-01 | 2017-03-20 |
NCT02160236 | Postoperative Pain | Drug: dexketoprofen trometamol|Drug: tenoxicam|Drug: serum physiologic | TC Erciyes University | Phase 4 | 2014-11-01 | 2014-11-07 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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