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Pramipexole

普拉克索,SND 919,Mirapex,Mirapexin,Sifrol,SND-919,SND919,

Pramipexole是多巴胺受体激动剂，对帕金森综合症和腿多动综合征有效。

目录号
EY0630
EY0630
纯度
99.64%
99.64%
规格
100 mg
500 mg
原价
130
485
售价
130
485
库存
现货
现货
订购
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  • 生物活性

    Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Millan, M.J., et al., Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther, 2002. 303(2): p. 791-804.
    [2] Kvernmo, T., S. Hartter, and E. Burger, A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78.
    [3] Weber, M., et al., Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation. Behav Pharmacol, 2008. 19(8): p. 786-95.

    分子式
    C10H17N3S    		 分子量
    211.33    		 CAS号
    104632-26-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    43 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    43 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01106053 Binge Eating Disorder Drug: Pramipexole Neuropsychiatric Research Institute, Fargo, North Dakota Phase 3 2010-04-01 2013-05-03
    NCT01651377 Cocaine Addiction|Cocaine Abuse|Cocaine Dependence|Substance Abuse Drug: Pramipexole|Drug: Placebo Baylor College of Medicine|National Institute on Drug Abuse (NIDA) Phase 1 2011-10-01 2014-07-18
    NCT02660060 Healthy Drug: Pramipexole Dexa Medica|Drug: Pramipexole Boehringer Ingelheim Pharma Dexa Medica Group 2015-05-01 2016-01-17
    NCT01388478 Alzheimer's Disease Drug: R-pramipexole Virginia Commonwealth University|University of Kansas Medical Center|Alzheimer鈥檚 Drug Discovery Foundation Phase 2 2011-07-01 2016-03-22
    NCT01441284 Essential Tremor Drug: pramipexole|Drug: placebo University of Pecs Phase 3 2017-03-01 2016-10-30
    NCT01673724 Parkinson's Disease Drug: pramipexole|Drug: Bromocriptine Sandoz Phase 4 2012-02-01 2012-09-03
    NCT00558025 Parkinson Disease Drug: Pramipexole Extended Release|Drug: Pramipexole Immediate Release Boehringer Ingelheim Phase 3 2007-10-01 2014-05-07
    NCT01361009 Parkinson Disease Drug: pramipexole Boehringer Ingelheim 2011-05-01 2014-05-07
    NCT02397837 Bipolar Disorder Drug: Pramipexole|Drug: Placebo Icahn School of Medicine at Mount Sinai|The Zucker Hillside Hospital|Northwell Health|National Institute of Mental Health (NIMH) Phase 4 2014-10-01 2016-12-02
    NCT00577460 Parkinson Disease Drug: Pramipexole|Drug: Placebo Boehringer Ingelheim Phase 3 2007-12-01 2014-05-07
    NCT00931944 Amyotrophic Lateral Sclerosis Drug: KNS-760704 Knopp Biosciences Phase 2 2009-07-01 2014-10-13
    NCT01074450 Healthy Drug: Pramipexole Dihydrochloride|Drug: Pramipexole Dihydrochloride Teva Pharmaceuticals USA Phase 1 2005-02-01 2010-04-08
    NCT01074463 Healthy Drug: Pramipexole Dihydrochloride|Drug: Pramipexole Dihydrochloride Teva Pharmaceuticals USA Phase 1 2005-02-01 2010-04-08
    NCT00601523 Parkinson Disease Drug: Placebo|Drug: Pramipexole Boehringer Ingelheim Phase 3 2008-01-01 2014-06-03
    NCT00321854 Parkinson Disease Drug: pramipexole Boehringer Ingelheim Phase 4 2006-05-01 2014-05-07
    NCT02248220 Parkinson Disease Drug: Pramipexole Boehringer Ingelheim 1998-10-01 2014-09-22
    NCT00560508 Parkinson Disease Drug: Pramipexole Immediate Release|Drug: Pramipexole Extended Release Boehringer Ingelheim Phase 2|Phase 3 2007-11-01 2014-07-29
    NCT02236728 Parkinson Disease Drug: Pramipexole Boehringer Ingelheim 2008-02-01 2014-09-10
    NCT00275275 Parkinson Disease Drug: Requip PR|Drug: Mirapex Rajesh Pahwa, MD|GlaxoSmithKline|University of Kansas Medical Center Phase 3 2006-01-01 2012-07-21
    NCT01470859 Idiopathic Parkinson's Disease Drug: pramipexole|Drug: Sinemet CR Huashan Hospital|Boehringer Ingelheim 2011-12-01 2015-09-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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