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NMDA

N-甲基-D-天冬氨酸,N-Methyl-D-aspartic acid

NMDA(N-Methyl-D-aspartic acid)是氨基酸衍生物,是NMDA受体特异性激动剂,能模拟谷氨酸作用于该受体的效应。

目录号
EY0625
EY0625
纯度
99.48%
99.48%
规格
50 mg
100 mg
原价
445
720
售价
445
720
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Cull-Candy S, et al. Curr Opin Neurobiol, 2001, 11(3), 327-335.
    [2] Cain, D.P. 1998. Neurosci Biobehav Rev. 22: 181-193.
    [3] Hansen, J.J., et al. 1990. Med Res Rev. 10: 55-94.
    [4] Manfridi, A., et al. 1999. Am. J. Physiol. 277: R1488-R1492.

    分子式
    C5H9NO4
    分子量
    147.13
    CAS号
    6384-92-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    5 mg/mL
    Water
    30 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01602185 Neuropathic Pain Drug: Dextromethorphan (drug used like antitussive)|Drug: Memantine (drug used in Alzheimer's disease)|Drug: Placebo (lactose) University Hospital, Clermont-Ferrand|Dr Malou Navez, Pain Clinic, Saint-Etienne Hopital|Dr Marc Sorel, Pain Clinic, Nemours Hospital|Dr Anne-Margot Duclot, Pain Clinic, Paris Rotschild Hospital|Dr Monique Belon, Pain Clinic, Aurillac Hospital|Dr Marie-Christine Crosmary/Dr Renato Colamarino, Pain Clinic, Vichy Hospital|Dr Mohamed El Ayadi, Pain Clinic, Issoire Hospital|Dr G茅raldine Brumauld de Montgazon, Pain Clinic, La Rochelle Hospital Phase 2 2012-05-01 2012-10-08
    NCT01553435 Pain|Opioid Tolerance|Analgesia Tolerance Drug: Dextromethorphan|Drug: Placebo King Abdullah International Medical Research Center 2011-01-01 2015-04-12
    NCT00163059 Depressive Disorder, Major Drug: NMDA Antagonist, CP-101,606 (traxoprodil) Pfizer Phase 2 2004-05-01 2006-09-21
    NCT00163085 Parkinson's Disease Drug: NR2B NMDA Antagonist CP-101,606 (traxoprodil) Pfizer Phase 2 2005-05-01 2006-09-21
    NCT01474395 Schizophrenia|Schizoaffective Disorder Drug: D-serine|Drug: placebo|Behavioral: Sensory Based remediation paradigm Nathan Kline Institute for Psychiatric Research|Columbia University Phase 2 2012-03-01 2012-10-24
    NCT02950233 Pain, Postoperative Drug: NDMA|Drug: Steroid|Drug: NDMA Placebo|Drug: Steroid Placebo Population Health Research Institute Phase 3 2017-01-01 2016-10-31
    NCT00611897 Cognitive Dysfunction Drug: N-acetylcysteine and ketamine|Drug: placebo and ketamine Yale University Phase 1|Phase 2 2006-01-01 2015-05-07
    NCT01047592 Schizophrenia Drug: sarcosine|Drug: sarcosine+ BE|Drug: placebo Chang-Hua Hospital|China Medical University Hospital Phase 2 2009-03-01 2014-07-06
    NCT02994433 Depressive Disorder, Major|Depressive Disorder, Treatment-Resistant Drug: Nitrous Oxide|Drug: Placebo gas|Device: MRI Washington University School of Medicine Phase 1 2016-07-01 2016-12-14
    NCT02087202 Pain Drug: Magnesium Sulfate|Drug: ketamine Seoul National University Bundang Hospital 2014-03-01 2014-03-12
    NCT00218465 Nicotine Dependence Drug: GW468816|Drug: Placebo Comparator: Placebo Massachusetts General Hospital|National Institute on Drug Abuse (NIDA)|Mclean Hospital|GlaxoSmithKline Phase 2 2006-08-01 2017-03-22
    NCT02675530 Schizophrenia Drug: ketamine Yale University|AstraZeneca Phase 1 2007-12-01 2016-02-04
    NCT00188383 Hyperalgesia|Pain|Prostate Cancer Drug: Amantadine University Health Network, Toronto|Canadian Institutes of Health Research (CIHR) Phase 1|Phase 2 2004-01-01 2006-03-13
    NCT00205712 Psychoses, Substance-Induced Drug: Ketamine|Drug: Dexmedetomidine Washington University School of Medicine|National Alliance for Research on Schizophrenia and Depression Phase 4 2003-02-01 2016-01-12
    NCT00364429 Schizophrenia Drug: [123]I-CNS 1261|Drug: Lorazepam|Drug: Risperidone GlaxoSmithKline Phase 1 2005-07-01 2016-01-07
    NCT01865578 Anti-NMDA Receptor Encephalitis Device: tDCS|Device: Sham Stimulation Charite University, Berlin, Germany 2012-04-01 2016-03-16
    NCT02426983 Schizophrenia Device: Direct Current Stimulation|Drug: Dextromethorphan University of Ottawa Phase 1|Phase 2 2015-04-01 2015-04-21
    NCT01722578 Cirrhosis of Liver|Hepatic Encephalopathy Drug: L-ornithine L-aspartate|Drug: Placebo Dayanand Medical College and Hospital Phase 4 2013-12-01 2017-02-06
    NCT00338598 Alcoholism|Schizophrenia Drug: Glycine|Drug: placebo Yale University|Stanley Medical Research Institute Phase 2 2003-06-01 2016-07-11
    NCT02373124 Cocaine Use Disorders Drug: infusion of NMDA antagonist New York State Psychiatric Institute Phase 1|Phase 2 2014-12-01 2016-06-13

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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