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Busulfan

白消安,Busulfex,Myleran,Busilvex

Busulfan是烷化剂。

目录号
EY0616
EY0616
纯度
99.39%
99.39%
规格
100 mg
500 mg
原价
130
380
售价
130
380
库存
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Busulfan is a cell cycle non-specific alkylating antineoplastic agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Meng A, et al. Cancer Res, 2003, 63(17), 5414-5419.
    [2] Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway: V. Probin, et al.; Free Radic. Biol. Med. 42, 1858 (2007)
    [3] Kinetic of genotoxic expression in the pharmacodynamics of busulfan: P. Morales-Ramirez, et al.; Arch. Med. Res. 37, 316 (2006)
    [4] DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect: T. Iwamoto, et al.; Cancer Sci. 95, 454 (2004)

    分子式
    C6H14O6S2
    分子量
    246.31
    CAS号
    55-98-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01800643 Acute Leukemia|Chronic Leukemia|Lymphoproliferative Disease|Myeloproliferative Disease|Immunodeficiency Other: Analyze the pharmacokinetics of busulfan for transplantation Hospital Israelita Albert Einstein Phase 2|Phase 3 2010-03-01 2014-12-02
    NCT01048827 Acute Myeloid Leukemia Drug: Busulfan University of California, San Francisco Phase 1 2009-11-01 2015-01-26
    NCT01498016 Acute Leukemia Drug: Busulfan Shanghai Jiao Tong University School of Medicine Phase 2 2011-11-01 2016-05-09
    NCT01257854 Children Who Receive a Stem Cell Transplantation With Busulfan IV Swiss Pediatric Oncology Group|European Group for Blood and Marrow Transplantation 2008-02-01 2017-01-31
    NCT00852163 Leukemia|Myelodysplastic Syndrome Drug: Clofarabine with Busulfan Baylor Research Institute|Genzyme, a Sanofi Company Phase 2 2007-03-01 2013-04-01
    NCT01018446 Hematopoietic Stem Cell Transplantation Drug: Busulfan Seoul National University Hospital Phase 1 2008-12-01 2013-11-17
    NCT00113919 Multiple Myeloma Drug: Busulfan University of Arkansas Phase 1|Phase 2 2004-06-01 2015-04-10
    NCT01009840 Multiple Myeloma Drug: IV busulfan|Drug: bortezomib|Procedure: Autologous Hematopoietic Stem Cell Transplant (HSCT) Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 2 2010-05-01 2014-09-23
    NCT00427765 Multiple Myeloma|Lymphoma Drug: Busulfan|Drug: Melphalan M.D. Anderson Cancer Center Phase 2 2004-12-01 2011-12-15
    NCT00934232 Multiple Myeloma Drug: Busulfan Guido Tricot|Otsuka Pharmaceutical Development & Commercialization, Inc.|University of Iowa Phase 1|Phase 2 2009-08-01 2013-11-26
    NCT02034630 Genetic Rare Disease Drug: Busulfan Seoul National University Hospital Phase 1|Phase 2 2014-01-01 2015-05-26
    NCT02047578 Acute Lymphoblastic Leukemia Drug: Busulfan Seoul National University Hospital Phase 2 2014-01-01 2015-05-26
    NCT00328029 Signs and Symptoms, Respiratory Drug: busulfan|Procedure: respiratory function tests|Procedure: pharmacokinetics, done during the treatment University Hospital, Strasbourg, France Phase 2 2006-07-01 2009-02-24
    NCT00502905 Leukemia Drug: Busulfan|Drug: Fludarabine M.D. Anderson Cancer Center Phase 2 2003-10-01 2012-05-23
    NCT00506857 Hematologic Malignancies Drug: Busulfan|Drug: Fludarabine M.D. Anderson Cancer Center Phase 1|Phase 2 2003-11-01 2012-01-24
    NCT00948090 Lymphoma Drug: IV Busulfan, Cyclophosphamide and Etoposide (BuCyE Regimen) Otsuka Pharmaceutical Development & Commercialization, Inc.|Center for International Blood and Marrow Transplant Research Phase 2 2010-01-01 2014-07-01
    NCT01923935 Multiple Myeloma Drug: BUSULFEX庐|Drug: Alkeran庐 Chonnam National University Hospital|Korea Otsuka Pharmaceutical Co., Ltd. Phase 2 2013-01-01 2013-08-15
    NCT01959477 Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Grade III Lymphomatoid Granulomatosis|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Contiguous Stage II Adult Burkitt Lymphoma|Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Contiguous Stage II Adult Lymphoblastic Lymphoma|Contiguous Stage II Grade 1 Follicular Lymphoma|Contiguous Stage II Grade 2 Follicular Lymphoma|Contiguous Stage II Grade 3 Follicular Lymphoma|Contiguous Stage II Mantle Cell Lymphoma|Contiguous Stage II Marginal Zone Lymphoma|Contiguous Stage II Small Lymphocytic Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Adult Burkitt Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage I Adult Burkitt Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Mixed Cell Lymphoma|Stage I Adult Diffuse Small Cleaved Cell Lymphoma|Stage I Adult Hodgkin Lymphoma|Stage I Adult Immunoblastic Large Cell Lymphoma|Stage I Adult Lymphoblastic Lymphoma|Stage I Adult T-cell Leukemia/Lymphoma|Stage I Childhood Anaplastic Large Cell Lymphoma|Stage I Childhood Hodgkin Lymphoma|Stage I Childhood Large Cell Lymphoma|Stage I Childhood Lymphoblastic Lymphoma|Stage I Childhood Small Noncleaved Cell Lymphoma|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Grade 3 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Small Lymphocytic Lymphoma|Stage IA Mycosis Fungoides/Sezary Syndrome|Stage IB Mycosis Fungoides/Sezary Syndrome|Stage II Adult Hodgkin Lymphoma|Stage II Adult T-cell Leukemia/Lymphoma|Stage II Childhood Anaplastic Large Cell Lymphoma|Stage II Childhood Hodgkin Lymphoma|Stage II Childhood Large Cell Lymphoma|Stage II Childhood Lymphoblastic Lymphoma|Stage II Childhood Small Noncleaved Cell Lymphoma|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIA Mycosis Fungoides/Sezary Syndrome|Stage IIB Mycosis Fungoides/Sezary Syndrome|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Childhood Anaplastic Large Cell Lymphoma|Stage III Childhood Hodgkin Lymphoma|Stage III Childhood Large Cell Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage III Childhood Small Noncleaved Cell Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IIIA Mycosis Fungoides/Sezary Syndrome|Stage IIIB Mycosis Fungoides/Sezary Syndrome|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Childhood Anaplastic Large Cell Lymphoma|Stage IV Childhood Hodgkin Lymphoma|Stage IV Childhood Large Cell Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|Stage IV Childhood Small Noncleaved Cell Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Stage IVA Mycosis Fungoides/Sezary Syndrome|Stage IVB Mycosis Fungoides/Sezary Syndrome|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenstr枚m Macroglobulinemia Drug: busulfan|Drug: etoposide|Drug: cyclophosphamide|Procedure: peripheral blood stem cell transplantation|Procedure: autologous hematopoietic stem cell transplantation Case Comprehensive Cancer Center|National Cancer Institute (NCI) Early Phase 1 2014-03-01 2015-08-12
    NCT01274195 Hematopoietic Stem Cell Transplantation Drug: Busulfan Seoul National University Hospital Phase 2 2011-01-01 2013-11-17
    NCT02083250 Leukemia Drug: Fludarabine|Drug: Clofarabine|Drug: Busulfan|Drug: SAHA|Procedure: Stem Cell Infusion (SCT)|Drug: Thymoglobulin M.D. Anderson Cancer Center Phase 1 2014-03-01 2016-09-06
    NCT01339988 Acute Leukemias|Chronic Leukemias|Myelodysplastic Syndrome|Juvenile Myelomonocytic Leukemia Drug: Busulfan/Cyclophosphamide Tel-Aviv Sourasky Medical Center Phase 4 2011-06-01 2011-04-20

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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