Busulfan是烷化剂。
Busulfan is a cell cycle non-specific alkylating antineoplastic agent.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Meng A, et al. Cancer Res, 2003, 63(17), 5414-5419.
[2] Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway: V. Probin, et al.; Free Radic. Biol. Med. 42, 1858 (2007)
[3] Kinetic of genotoxic expression in the pharmacodynamics of busulfan: P. Morales-Ramirez, et al.; Arch. Med. Res. 37, 316 (2006)
[4] DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect: T. Iwamoto, et al.; Cancer Sci. 95, 454 (2004)
分子式 C6H14O6S2 |
分子量 246.31 |
CAS号 55-98-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01800643 | Acute Leukemia|Chronic Leukemia|Lymphoproliferative Disease|Myeloproliferative Disease|Immunodeficiency | Other: Analyze the pharmacokinetics of busulfan for transplantation | Hospital Israelita Albert Einstein | Phase 2|Phase 3 | 2010-03-01 | 2014-12-02 |
NCT01048827 | Acute Myeloid Leukemia | Drug: Busulfan | University of California, San Francisco | Phase 1 | 2009-11-01 | 2015-01-26 |
NCT01498016 | Acute Leukemia | Drug: Busulfan | Shanghai Jiao Tong University School of Medicine | Phase 2 | 2011-11-01 | 2016-05-09 |
NCT01257854 | Children Who Receive a Stem Cell Transplantation With Busulfan IV | Swiss Pediatric Oncology Group|European Group for Blood and Marrow Transplantation | 2008-02-01 | 2017-01-31 | ||
NCT00852163 | Leukemia|Myelodysplastic Syndrome | Drug: Clofarabine with Busulfan | Baylor Research Institute|Genzyme, a Sanofi Company | Phase 2 | 2007-03-01 | 2013-04-01 |
NCT01018446 | Hematopoietic Stem Cell Transplantation | Drug: Busulfan | Seoul National University Hospital | Phase 1 | 2008-12-01 | 2013-11-17 |
NCT00113919 | Multiple Myeloma | Drug: Busulfan | University of Arkansas | Phase 1|Phase 2 | 2004-06-01 | 2015-04-10 |
NCT01009840 | Multiple Myeloma | Drug: IV busulfan|Drug: bortezomib|Procedure: Autologous Hematopoietic Stem Cell Transplant (HSCT) | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 2 | 2010-05-01 | 2014-09-23 |
NCT00427765 | Multiple Myeloma|Lymphoma | Drug: Busulfan|Drug: Melphalan | M.D. Anderson Cancer Center | Phase 2 | 2004-12-01 | 2011-12-15 |
NCT00934232 | Multiple Myeloma | Drug: Busulfan | Guido Tricot|Otsuka Pharmaceutical Development & Commercialization, Inc.|University of Iowa | Phase 1|Phase 2 | 2009-08-01 | 2013-11-26 |
NCT02034630 | Genetic Rare Disease | Drug: Busulfan | Seoul National University Hospital | Phase 1|Phase 2 | 2014-01-01 | 2015-05-26 |
NCT02047578 | Acute Lymphoblastic Leukemia | Drug: Busulfan | Seoul National University Hospital | Phase 2 | 2014-01-01 | 2015-05-26 |
NCT00328029 | Signs and Symptoms, Respiratory | Drug: busulfan|Procedure: respiratory function tests|Procedure: pharmacokinetics, done during the treatment | University Hospital, Strasbourg, France | Phase 2 | 2006-07-01 | 2009-02-24 |
NCT00502905 | Leukemia | Drug: Busulfan|Drug: Fludarabine | M.D. Anderson Cancer Center | Phase 2 | 2003-10-01 | 2012-05-23 |
NCT00506857 | Hematologic Malignancies | Drug: Busulfan|Drug: Fludarabine | M.D. Anderson Cancer Center | Phase 1|Phase 2 | 2003-11-01 | 2012-01-24 |
NCT00948090 | Lymphoma | Drug: IV Busulfan, Cyclophosphamide and Etoposide (BuCyE Regimen) | Otsuka Pharmaceutical Development & Commercialization, Inc.|Center for International Blood and Marrow Transplant Research | Phase 2 | 2010-01-01 | 2014-07-01 |
NCT01923935 | Multiple Myeloma | Drug: BUSULFEX庐|Drug: Alkeran庐 | Chonnam National University Hospital|Korea Otsuka Pharmaceutical Co., Ltd. | Phase 2 | 2013-01-01 | 2013-08-15 |
NCT01959477 | Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Grade III Lymphomatoid Granulomatosis|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Contiguous Stage II Adult Burkitt Lymphoma|Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Contiguous Stage II Adult Lymphoblastic Lymphoma|Contiguous Stage II Grade 1 Follicular Lymphoma|Contiguous Stage II Grade 2 Follicular Lymphoma|Contiguous Stage II Grade 3 Follicular Lymphoma|Contiguous Stage II Mantle Cell Lymphoma|Contiguous Stage II Marginal Zone Lymphoma|Contiguous Stage II Small Lymphocytic Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Adult Burkitt Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage I Adult Burkitt Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Mixed Cell Lymphoma|Stage I Adult Diffuse Small Cleaved Cell Lymphoma|Stage I Adult Hodgkin Lymphoma|Stage I Adult Immunoblastic Large Cell Lymphoma|Stage I Adult Lymphoblastic Lymphoma|Stage I Adult T-cell Leukemia/Lymphoma|Stage I Childhood Anaplastic Large Cell Lymphoma|Stage I Childhood Hodgkin Lymphoma|Stage I Childhood Large Cell Lymphoma|Stage I Childhood Lymphoblastic Lymphoma|Stage I Childhood Small Noncleaved Cell Lymphoma|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Grade 3 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Small Lymphocytic Lymphoma|Stage IA Mycosis Fungoides/Sezary Syndrome|Stage IB Mycosis Fungoides/Sezary Syndrome|Stage II Adult Hodgkin Lymphoma|Stage II Adult T-cell Leukemia/Lymphoma|Stage II Childhood Anaplastic Large Cell Lymphoma|Stage II Childhood Hodgkin Lymphoma|Stage II Childhood Large Cell Lymphoma|Stage II Childhood Lymphoblastic Lymphoma|Stage II Childhood Small Noncleaved Cell Lymphoma|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIA Mycosis Fungoides/Sezary Syndrome|Stage IIB Mycosis Fungoides/Sezary Syndrome|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Childhood Anaplastic Large Cell Lymphoma|Stage III Childhood Hodgkin Lymphoma|Stage III Childhood Large Cell Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage III Childhood Small Noncleaved Cell Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IIIA Mycosis Fungoides/Sezary Syndrome|Stage IIIB Mycosis Fungoides/Sezary Syndrome|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Childhood Anaplastic Large Cell Lymphoma|Stage IV Childhood Hodgkin Lymphoma|Stage IV Childhood Large Cell Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|Stage IV Childhood Small Noncleaved Cell Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Stage IVA Mycosis Fungoides/Sezary Syndrome|Stage IVB Mycosis Fungoides/Sezary Syndrome|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenstr枚m Macroglobulinemia | Drug: busulfan|Drug: etoposide|Drug: cyclophosphamide|Procedure: peripheral blood stem cell transplantation|Procedure: autologous hematopoietic stem cell transplantation | Case Comprehensive Cancer Center|National Cancer Institute (NCI) | Early Phase 1 | 2014-03-01 | 2015-08-12 |
NCT01274195 | Hematopoietic Stem Cell Transplantation | Drug: Busulfan | Seoul National University Hospital | Phase 2 | 2011-01-01 | 2013-11-17 |
NCT02083250 | Leukemia | Drug: Fludarabine|Drug: Clofarabine|Drug: Busulfan|Drug: SAHA|Procedure: Stem Cell Infusion (SCT)|Drug: Thymoglobulin | M.D. Anderson Cancer Center | Phase 1 | 2014-03-01 | 2016-09-06 |
NCT01339988 | Acute Leukemias|Chronic Leukemias|Myelodysplastic Syndrome|Juvenile Myelomonocytic Leukemia | Drug: Busulfan/Cyclophosphamide | Tel-Aviv Sourasky Medical Center | Phase 4 | 2011-06-01 | 2011-04-20 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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