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Acipimox

阿西莫司,乐脂平,阿昔莫司,Olbemox,K-9321,K9321,K 9321,Olbetam

Acipimox是烟酸衍生物,可降血脂。

目录号
EY0614
EY0614
纯度
99.29%
99.29%
规格
50 mg
100 mg
原价
590
998
售价
590
998
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Acipimox is a niacin derivative used as a hypolipidemic agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Cayen, M.N., et al. 1982. Atherosclerosis. 45: 267-279.
    [2] Wise, A., et al, 2003. J. Biol. Chem. 278: 9869-9874.
    [3] Jung, J.K., et al. 2007. J. Med. Chem. 50: 1445-1448.

    分子式
    C6H6N2O3
    分子量
    154.12
    CAS号
    51037-30-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    100 mM
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02796950 Diabetes Mellitus Type 2 Drug: Acipimox University of Aarhus 2016-06-01 2016-06-07
    NCT00943059 Diabetes Mellitus, Type 2|Cardiomyopathy, Dilated Drug: Acipimox|Drug: Cellulosum Mycrocryst Maastricht University Medical Center|Center for Translational Molecular Medicine 2010-03-01 2013-05-13
    NCT01816165 Type 1 Diabetes Drug: Acipimox|Drug: Placebo University of Colorado, Denver Phase 3 2011-06-01 2017-02-16
    NCT01488409 Abdominal Obesity|Insulin Resistance|Hypertriglyceridemia Drug: Acipimox|Drug: Placebo Massachusetts General Hospital|American Diabetes Association Phase 2 2012-05-01 2016-02-02
    NCT01580813 Type 2 Diabetes Drug: Acipimox|Drug: Placebo University of Colorado, Denver|VA Office of Research and Development|Pfizer 2011-06-01 2017-03-16
    NCT01260376 Diabetes|Obesity Drug: Acipimox University of Aarhus 2011-04-01 2012-09-17
    NCT00246402 Insulin Resistance|Cardiovascular Diseases|Heart Diseases|HIV Infections|Hypertriglyceridemia|Hyperlipidemia Drug: Acipimox National Heart, Lung, and Blood Institute (NHLBI) 2002-09-01 2014-05-14
    NCT00549614 Heart Failure Drug: acipimox|Drug: placebo University of Aarhus 2007-10-01 2009-10-06
    NCT02782208 Hypopituitarism|Insulin Resistance|Endocrine System Diseases|Glucose Metabolism Disorders|Metabolic Diseases|Pituitary Diseases|Brain Diseases Drug: Acipimox|Drug: Placebo|Drug: GH substitution|Other: GH pause University of Aarhus 2016-05-01 2016-05-20
    NCT02256722 Healthy Drug: KUC 7483 CL|Drug: Bisoprolol|Drug: Propranolol|Drug: Acipimox|Drug: Salmeterol Boehringer Ingelheim Phase 1 2005-10-01 2014-10-02
    NCT00153179 Type 2 Diabetes Mellitus Drug: acipimox|Drug: placebo Brigham and Women's Hospital Phase 1|Phase 2 2005-09-01 2013-05-30
    NCT01980524 Type 2 Diabetes Drug: acipimox Medical University of Vienna Phase 2|Phase 3 2013-10-01 2016-05-04
    NCT01209416 Metabolism|Insulin Resistance|Hypopituitarism Drug: Acipimox|Drug: Ghrelin|Other: Placebo University of Aarhus 2012-06-01 2014-12-02
    NCT02980952 Assessing Muscle Amino Acid Balance Other: overfeeding|Drug: Acipimox|Other: Physical inactivity|Dietary Supplement: Eucaloric|Dietary Supplement: Placebo|Dietary Supplement: Hypercaloric University of Exeter 2017-01-01 2016-12-01
    NCT00759291 Metabolic Syndrome Drug: acipimox|Drug: matching placebo Brigham and Women's Hospital Phase 2|Phase 3 2006-04-01 2016-09-14
    NCT02792621 Impaired Mitochondrial Function, Muscle Performance Dietary Supplement: Acipimox|Dietary Supplement: placebo Royal Devon and Exeter NHS Foundation Trust|University of Exeter 2016-11-08 2017-02-20
    NCT00449423 Acute Heart Failure Drug: acipimox University of Aarhus Phase 2 2007-03-01 2007-10-24
    NCT01752348 Systemic Inflammatory Response Syndrome Other: Endotoxin, US standard reference E.coli University of Aarhus 2013-02-01 2014-11-24
    NCT01299831 Healthy Behavioral: 72 hour fast|Behavioral: control, 12 hour fast|Drug: Growth hormone|Drug: Olbetam University of Aarhus|Aarhus University Hospital 2011-01-01 2014-05-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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