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Pregnenolone

孕烯醇酮,妊娠烯醇酮 3β-Hydroxy-5-pregnen-20-one

Pregnenolone (孕烯诺龙) 是内源性甾体激素，能抑制M1和M3受体介导的电流，IC50分别为11.4和6.0 μM。

目录号
EY0610
EY0610
纯度
99.46%
99.46%
规格
100 mg
500 mg
原价
130
389
售价
130
389
库存
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Murakami K, et al. Proc Natl Acad Sci U S A, 2000, 97(7), 3579-3584.
    [2] Shen W, Mennerick S, Covey DF, Zorumski CF. J Neurosci. 20:3571-9 (2000).
    [3] Cascio C, Guarneri R, Russo D et al. J Neurochem. 74:2380-91(Grigoryev DN, Long BJ, Njar VC, Brodie AH. J Steroid Biochem Mol Biol. 75:1-10 (2000).

    分子式
    C21H32O2    		 分子量
    316.48    		 CAS号
    145-13-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    22 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    22 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01881737 Autistic Disorder Drug: Pregnenolone Stanford University Phase 2 2011-07-01 2015-12-02
    NCT02627508 Autism Spectrum Disorder|Autism Drug: Pregnenolone|Drug: Placebo Stanford University|Simons Foundation Phase 2 2015-12-01 2017-02-08
    NCT00560781 Stress Disorders, Post-Traumatic Drug: Pregnenolone or Placebo Durham VA Medical Center 2006-04-01 2014-02-25
    NCT00900900 Substance Withdrawal Syndrome Dietary Supplement: dehydroepiandrosterone (DHEA)|Dietary Supplement: pregnenolone|Drug: Placebo Jed E. Rose|Duke University Phase 2 2009-07-01 2012-09-14
    NCT00728728 Schizophrenia|Schizoaffective Disorder Drug: Dietary Supplement: Pregnenolone|Dietary Supplement: Placebo VA Office of Research and Development Phase 2 2009-12-01 2016-12-19
    NCT00623506 Traumatic Brain Injury Drug: Pregnenolone|Drug: Placebo Durham VA Medical Center 2008-01-01 2013-05-13
    NCT02439814 Marijuana Dependence Drug: Pregnenolone|Other: Placebo Medical University of South Carolina Phase 2 2015-06-01 2016-09-12
    NCT01409096 Bipolar Disorder|Major Depressive Disorder Drug: Pregnenolone|Drug: Placebo University of Texas Southwestern Medical Center|Stanley Medical Research Institute Phase 4 2010-03-01 2016-03-01
    NCT00560937 Schizophrenia Drug: Pregnenolone|Drug: Placebo Durham VA Medical Center 2005-06-01 2015-08-11
    NCT00615511 Schizophrenia|Schizoaffective Disorder Dietary Supplement: placebo pregnenolone|Dietary Supplement: pregnenolone Weill Medical College of Cornell University|Stanley Medical Research Institute Phase 2 2007-06-01 2015-12-18
    NCT00993629 Post-traumatic Stress Disorder|Major Depressive Disorder Drug: pregnenolone|Drug: placebo VA Office of Research and Development Phase 2 2010-01-01 2014-10-23
    NCT00894842 Schizophrenia Drug: Pregnenolone|Drug: Placebo National Research Foundation, Singapore|Duke University|National University, Singapore|Singapore Clinical Research Institute Phase 2|Phase 3 2009-06-01 2011-10-04
    NCT00223197 Bipolar Disorder|Major Depressive Disorder|Substance Abuse Drug: Pregnenolone University of Texas Southwestern Medical Center|Stanley Medical Research Institute Phase 4 2004-02-01 2012-04-02
    NCT02811939 Healthy Drug: Active Dronabinol|Drug: Active Pregnenolone|Drug: Placebo Dronabinol|Drug: Placebo Pregnenolone Yale University Phase 1 2016-03-01 2017-01-05
    NCT02576912 Healthy Drug: Active Delta-9-THC|Drug: Active Pregnenolone|Drug: Placebo|Drug: Placebo Yale University Phase 1 2015-02-01 2017-01-05
    NCT02826577 Perceived Social Isolation Drug: Pregnenolone 175mg|Drug: Pregnenolone 400mg|Drug: Placebo University of Chicago Phase 2 2016-12-01 2016-11-15
    NCT00912886 Alzheimer Disease Assistance Publique - H么pitaux de Paris 2009-09-01 2013-04-10
    NCT01898013 Lower Back Pain Drug: Pregnenolone|Drug: Placebo Durham VA Medical Center Phase 2|Phase 3 2013-09-01 2016-08-02
    NCT01336413 Brain Injuries, Traumatic Drug: Pregnenolone|Drug: Placebo VA Office of Research and Development Phase 2 2013-10-01 2016-04-26
    NCT01956279 Fatigue|Musculoskeletal Pain|Cognitive Decline Drug: Pregnenolone|Drug: Placebo VA Office of Research and Development Phase 2 2013-10-01 2016-11-17
    NCT00608686 Alcohol Intoxication Dietary Supplement: Pregnenolone National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 1 2004-05-01 2008-12-18
    NCT02582905 Alcohol Use Disorder|Bipolar Disorder Drug: Placebo|Drug: Citicoline|Drug: Pregnenolone University of Texas Southwestern Medical Center|University of Miami Phase 4 2016-05-01 2017-03-17
    NCT00611975 Healthy Drug: Fluoxetine|Drug: Bupropion Weill Medical College of Cornell University|National Institute of Mental Health (NIMH) Phase 4 2005-10-01 2012-06-27
    NCT02738580 Infertility|Controlled Ovarian Hyperstimulation Drug: COS with GnRH antagonists and rFSH|Drug: COS with GnRH antagonists and HP-HMG Instituto Valenciano de Infertilidad, IVI VALENCIA|Roche Pharma AG Phase 4 2016-10-01 2016-10-04
    NCT00678574 Premenstrual Dysphoric Disorder|Premenstrual Syndrome Drug: fluoxetine University of Pennsylvania|National Institute of Mental Health (NIMH) Phase 4 1998-03-01 2017-01-03
    NCT00626340 Menopause|Depression Drug: MDD diagnosis and Estrogen treatment|Drug: MDD diagnosis and Fluoxetine treatment|Drug: MDD diagnosis with both Estrogen and Fluoxetine treatment|Drug: No depression and estrogen treatment University of Pennsylvania Phase 4 1999-07-01 2017-02-13
    NCT00656318 Healthy Other: oral contraceptive pill (OCP; OCPs) Yale University 2008-08-01 2009-08-24
    NCT00044252 Epilepsy National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) 2002-07-26 2017-01-24
    NCT02423096 Schizophrenia Drug: Risperidone Chang Gung Memorial Hospital 2013-12-01 2016-11-09
    NCT02512458 Bone Metastatic Prostate Cancer Drug: Cabazitaxel Hellenic Cooperative Oncology Group|Sanofi Phase 2 2015-07-01 2016-11-25
    NCT01650194 Metastatic Castration-Resistant Prostate Cancer Drug: enzalutamide|Drug: abiraterone acetate|Drug: prednisone Astellas Pharma Global Development, Inc.|Medivation, Inc.|Astellas Pharma Inc Phase 2 2012-07-01 2017-02-27

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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