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Mycophenolate Mofetil

霉酚酸酯,麦考酚酯,吗替麦考酚酯,RS 61443,RS-61443,RS61443

Mycophenolate Mofetil是一种非竞争性的，选择性的，可逆的inosine monophosphate dehydrogenase I/II（次黄嘌呤核苷磷酸脱氢酶I/II）抑制剂， IC50分别为39 nM和27 nM。

目录号
EY0600
EY0600
EY0600
EY0600
纯度
99.18%
99.18%
99.18%
99.18%
规格
50 mg
100 mg
250 mg
500 mg
原价
577
920
1500
2600
售价
577
920
1500
2600
库存
现货
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0 - 10 μM

  • 动物实验

    ≤40 mg/kgi.v.

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Nakanishi T, et al. Int Immunopharmacol. 2010, 10(1), 91-97.
    [2] Galarza-Maldonado, C., et al. 2010. Autoimmun Rev.
    [3] Matsui, K., et al. 2010. Clin Exp Nephrol.
    [4] Schaier, M., et al. 2010. Rheumatology.

    分子式
    C23H31NO7    		 分子量
    433.49    		 CAS号
    128794-94-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >25 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01487577 Allogeneic Blood and Marrow Transplantation (BMT)|Graft Versus Host Disease Drug: Mycophenolate mofetil University of Pittsburgh Phase 2 2010-06-01 2016-05-13
    NCT02743247 Healthy Volunteers Drug: Tacrolimus|Drug: Mycophenolate mofetil Seoul National University Hospital|Ministry of Food and Drug Safety, Korea Phase 1 2015-10-01 2016-04-14
    NCT00301600 IGA Nephropathy Drug: Mycophenolate mofetil Nanjing University School of Medicine 2003-01-01 2010-05-25
    NCT00351377 Autoimmune Disease Drug: Enteric-coated Mycophenolate Sodium Novartis Pharmaceuticals|Novartis Phase 3 2006-06-01 2011-04-19
    NCT01854814 IgA Nephropathy Drug: Mycophenolate mofetil|Drug: Losartan Fan Fan Hou|Nanfang Hospital of Southern Medical University 2013-07-01 2016-11-11
    NCT01283841 Fasting Drug: Mycophenolate Mofetil Dr. Reddy's Laboratories Limited Phase 1 2007-11-01 2011-01-25
    NCT01283867 FED Drug: Mycophenolate Mofetil Dr. Reddy's Laboratories Limited Phase 1 2007-11-01 2011-01-25
    NCT01101802 Systemic Lupus Erythematosus|Atherosclerosis Drug: Mycophenolate mofetil|Drug: sugar pill Guy's and St Thomas' NHS Foundation Trust|Institute of Child Health, University College London, London, UK. Phase 4 2006-03-01 2011-09-27
    NCT01080417 Healthy Volunteers Drug: Mycophenolate Mofetil Capsule 250 mg Panacea Biotec Ltd 2008-06-01 2010-03-03
    NCT01080443 Healthy Volunteers Drug: Mycophenolate Mofetil Capsule 250 mg Panacea Biotec Ltd 2008-06-01 2010-03-11
    NCT00239005 Renal Transplant Drug: Enteric-Coated Mycophenolate Sodium (EC-MPS)|Drug: Mycophenolate Mofetil (MMF) Novartis Pharmaceuticals|Novartis Phase 4 2005-09-01 2011-02-23
    NCT01822483 Renal Transplantation Drug: Mycophenolate sodium|Drug: Mycophenolate mofetil Irmandade Santa Casa de Miseric贸rdia de Porto Alegre|Novartis Phase 4 2013-04-01 2015-04-01
    NCT00531635 Post Transplant in Immunosuppression w/CSA & Mycophenolate Mofetil Drug: Mycophenolate Mofetil King Faisal Specialist Hospital & Research Center Phase 1 2002-07-01 2011-12-11
    NCT01014442 Lung Transplantation Drug: mycophenolate mofetil Hoffmann-La Roche Phase 3 2010-01-01 2016-12-19
    NCT02630563 Pediatric Liver Transplantation Drug: Corticosteroids|Drug: Cyclosporine|Drug: mycophenolate mofetil Hoffmann-La Roche Phase 2 2003-05-01 2016-04-19
    NCT02809079 Neuromyelitis Optica Spectrum Disorders|Mycophenolate Mofetil|Efficacy and Safety Drug: Mycophenolate mofetil|Drug: Prednisone Third Affiliated Hospital, Sun Yat-Sen University|Zhongshan Ophthalmic Center, Sun Yet-san University|Nangfang Hospital, Southern Medical University Phase 4 2016-01-01 2016-06-19
    NCT01042457 Lupus Nephritis Drug: Mycophenolate mofetil Chulalongkorn University Phase 3 2009-05-01 2013-09-27
    NCT02896205 Systemic Sclerosis|Scleroderma|Interstitial Lung Disease Drug: Mycophenolate mofetil|Drug: Placebo Postgraduate Institute of Medical Education and Research Phase 3 2016-10-01 2016-11-04
    NCT02370693 Interstitial Lung Disease|ILD|Systemic Sclerosis|Scleroderma Drug: Bortezomib|Drug: Placebo|Drug: Mycophenolate mofetil Northwestern University|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2016-03-01 2017-01-20
    NCT00991510 Stable Renal Transplant Recipients Drug: mycophenolate mofetil (Myfenax)|Drug: mycophenolate mofetil (Cellcept) Teva Pharmaceutical Industries|Parexel Phase 4 2009-08-01 2013-10-29
    NCT00843856 Glomerulonephritis, Membranous Drug: tacrolimus|Drug: tacrolimus and mycophenolate mofetil Imperial College Healthcare NHS Trust Phase 4 2009-02-01 2017-03-03
    NCT01711489 Healthy Subjects|Pharmacokinetics of Isavuconazole|Pharmacokinetics of Plasma Mycophenolic Acid (MPA)|Pharmacokinetics of Plasma Phenolic Glucuronide of MPA (MPAG) Drug: isavuconazole|Drug: Mycophenolate mofetil Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc Phase 1 2012-03-01 2012-10-18
    NCT00943228 Acute Rejection of Renal Transplant Drug: mycophenolate mofetil Nova Scotia Health Authority Phase 4 2010-02-01 2012-08-08

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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