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Vitamin D3

维生素D3,Cholecalciferol

Cholecalciferol(Vitamin D3)是维生素D的天然存在形式，代谢激活后能诱导细胞分化和癌细胞增殖。

目录号
EY0594
EY0594
纯度
99.48%
99.48%
规格
50 mg
100 mg
原价
280
490
售价
280
490
库存
现货
现货
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  • 生物活性

    Vitamin D3 is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    ~ 100 nM

  • 动物实验

    ~10.0 mg/kg 口服

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ousley AM, et al. J Steroid Biochem Mol Biol, 2011, 125(3-5), 202-210.
    [2] Holick, M.F., Rec. Res. Canc. Res., 164, 3 (2003)
    [3] Palmer, H.G., et al.: Cancer Res., 63, 7799 (2003)
    [4] Welsh, J., et al.: J. Nutr., 133, 2425S (2003)

    分子式
    C27H44O    		 分子量
    384.64    		 CAS号
    67-97-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    65 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    65 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01877577 Crohn's Disease (CD)|Ulcerative Colitis (UC) Dietary Supplement: Vitamin D3 University of California, San Francisco 2012-04-01 2014-07-01
    NCT01650883 Vitamin D 25 OH Deficiency Dietary Supplement: Cholecalciferol|Dietary Supplement: Cholecalciferol 5,000 IU University of South Florida 2009-03-01 2012-07-25
    NCT00789880 Atopic Dermatitis|Psoriasis Drug: Vitamin D3|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID)|Consortium of Food Allergy Research Phase 2 2008-12-01 2015-06-02
    NCT01024777 Multiple Sclerosis|Vitamin D Deficiency Drug: Cholecalciferol|Drug: Cholecalciferol Johns Hopkins University Phase 1 2010-03-01 2013-02-05
    NCT00956839 Pancreatitis, Chronic Drug: Vitamin D3 (Cholecalciferol) Sanjay Gandhi Postgraduate Institute of Medical Sciences Phase 4 2009-07-01 2013-02-10
    NCT01045109 Prostate Cancer Dietary Supplement: cholecalciferol|Dietary Supplement: cholecalciferol Medical University of South Carolina Phase 2 2007-10-01 2011-08-04
    NCT02735200 Vitamin D Deficiency Drug: topical vitamin D3 in intervention group Dammam University Phase 1|Phase 2 2016-04-01 2017-01-23
    NCT00710021 Systemic Lupus Erythematosus|SLE|Lupus Drug: Vitamin D3|Drug: Vitamin D3 placebo National Institute of Allergy and Infectious Diseases (NIAID)|Autoimmunity Centers of Excellence Phase 2 2008-11-01 2015-11-07
    NCT02999204 Renal Insufficiency, Chronic|Vascular Stiffness|Bone Diseases, Metabolic Drug: Vitamin D3 Jewish General Hospital Phase 4 2014-01-01 2016-12-16
    NCT01709474 Systemic Lupus Erythematosus Drug: Vitamin D3 6000 IU|Drug: Vitamin D3 400 IU National Institute of Allergy and Infectious Diseases (NIAID)|Autoimmunity Centers of Excellence Phase 2 2013-06-01 2015-12-15
    NCT00858247 Obesity Dietary Supplement: Vitamin D3 Mayo Clinic|National Center for Research Resources (NCRR)|Thrasher Research Fund Phase 2 2009-04-01 2014-05-13
    NCT02535910 Hypovitaminosis D|Cardiovascular Diseases Dietary Supplement: vitamin D3|Dietary Supplement: 25(OH) D3|Dietary Supplement: Control University of Reading 2015-08-01 2015-09-23
    NCT02063334 Vitamin D Receptor Target Gene Expression|Serum 25(OH)D Concentration Dietary Supplement: Vitamin D3|Dietary Supplement: Placebo University of Eastern Finland Phase 1 2014-02-01 2016-07-28
    NCT00656929 Viral Upper Respiratory Tract Infection Dietary Supplement: Vitamin D3|Other: Placebo Winthrop University Hospital 2006-12-01 2008-04-10
    NCT00752401 Kidney Transplantation|Vitamin D Deficiency|Renal Osteodystrophy Drug: Cholecalciferol|Drug: Placebo Medical University of Vienna Phase 3 2009-05-01 2014-01-20
    NCT01508845 Vitamin D Deficiency Dietary Supplement: cholecalciferol|Dietary Supplement: cholecalciferol|Dietary Supplement: cholecalciferol|Dietary Supplement: cholecalciferol Tufts University|Pfizer 2012-01-01 2014-07-18
    NCT02359214 Cardiovascular Disease|Diabetes|Bone Disease Dietary Supplement: Vitamin D3|Other: Placebo University of Chester 2014-04-01 2016-10-25
    NCT01170507 Vitamin D Deficiency Drug: vitamin D3 1000 IU orally daily for 5 months|Drug: vitamin D3 3000 IU orally daily for 5 months|Drug: vitamin D3 5000 IU orally daily for 5 months|Drug: Placebo orally daily for 5 months King Faisal Specialist Hospital & Research Center Phase 1|Phase 2 2011-12-01 2016-08-29
    NCT00940719 Multiple Sclerosis Dietary Supplement: vitamin D3 Maastricht University Medical Center|Orbis Medical Centre 2009-08-01 2010-08-10
    NCT01268176 Vitamin D Deficiency Dietary Supplement: cholecalciferol Tufts University|Pfizer Phase 1 2010-12-01 2013-05-09
    NCT02407899 Diabetes Mellitus, Type 1 Drug: Saxagliptin|Drug: Vitamin D3|Drug: Insulin Second Xiangya Hospital of Central South University|National Clinical Research Center for Metabolic Diseases, China Phase 4 2015-03-01 2015-11-17

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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