Tranilast是抗过敏化合物。
Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Suzawa H, et al. Jpn J Pharmacol, 1992, 60(2), 91-96.
[2] Isaji, M., et al. 1997. Br. J. Pharmacol. 122: 1061-1066.
[3] Spiecker, M., et al. 2002. Mol. Pharmacol. 62: 856-863.
[4] Namazi, M.R. and Soma, J. 2005. Med. Hypotheses. 64: 1135-1137.
分子式 C18H17NO5 |
分子量 327.33 |
CAS号 53902-12-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >10 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00717808 | Rheumatoid Arthritis | Drug: Tranilast|Drug: Placebo comparator | Imperial College London|Nuon Therapeutics, Inc. | Phase 1 | 2008-09-01 | 2015-05-27 |
NCT01003613 | Pterygium | Drug: Tranilast, and Tissucol|Other: Beriplast P | Gildasio Castello de Almeida Junior|Hospital de Base|Sao Jose do Rio Preto University | Phase 3 | 2009-02-01 | 2012-04-16 |
NCT00995618 | Gout|Hyperuricemia | Drug: Tranilast|Drug: Febuxostat|Drug: Combination - Tranilast and Febuxostat | Nuon Therapeutics, Inc. | Phase 2 | 2009-09-01 | 2011-01-05 |
NCT00882024 | Active Rheumatoid Arthritis | Drug: Tranilast|Drug: Tranilast|Drug: Placebo | Nuon Therapeutics, Inc. | Phase 2 | 2009-03-01 | 2011-01-05 |
NCT01052987 | Gout|Hyperuricemia | Drug: Tranilast|Drug: Allopurinol|Drug: Combination - Tranilast and Allopurinol|Drug: 400 mg Allopurinol|Drug: High dose combination | Nuon Therapeutics, Inc. | Phase 2 | 2010-01-01 | 2011-01-05 |
NCT01109121 | Moderate to Severe Gout|Hyperuricemia | Drug: Combination 400|Drug: Allopurinol|Drug: Combination 600 | Nuon Therapeutics, Inc. | Phase 2 | 2010-06-01 | 2011-01-05 |
NCT00818805 | Allergic Conjunctivitis | Drug: Olopatadine 0.1%|Drug: Tranilast 0.5%|Drug: Placebo (Olopatadine)|Drug: Placebo (Tranilast) | Alcon Research | Phase 4 | 2008-07-01 | 2012-05-29 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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