Home > Topoisomerase & > Teniposide

Teniposide

替尼泊甙,NSC 122819,VM-26,Vumon,NSC-122819,NSC122819,VM26,VM 26

Teniposide(VM-26)是半合成的鬼臼毒素衍生物，能通过与拓扑异构酶II的相互作用促使DNA断裂。

目录号
EY0578
EY0578
EY0578
EY0578
纯度
99.56%
99.56%
99.56%
99.56%
规格
5 mg
10 mg
25 mg
50 mg
原价
188
320
640
990
售价
188
320
640
990
库存
现货
现货
现货
现货
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  • 生物活性

    Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma: J. Li, et al.; World J. Surg. Oncol. 4, 41 (2006)
    [2] Topoisomerase II as a target of VM-26 and 4-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells: S de Jong, et al.; Cancer Res. 53, 1064 (1993)
    [3] Human cytochrome P450 metabolism of teniposide and etoposide: M.V. Relling, et al.; J. Pharmacol. Exp. Ther. 261, 491 (1992)

    分子式
    C32H32O13S    		 分子量
    656.65    		 CAS号
    29767-20-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    40 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00004916 Lymphoma Drug: ifosfamide|Drug: paclitaxel|Drug: teniposide|Procedure: peripheral blood stem cell transplantation Northwestern University|National Cancer Institute (NCI) Phase 1|Phase 2 1999-02-01 2012-05-31
    NCT01960192 Primary CNS Lymphoma (PCNSL) Drug: HD-MTX-Ara-C regimen|Drug: FVD regimen Mingzhi Zhang|Zhengzhou University Phase 4 2012-06-01 2015-07-19
    NCT00186875 Acute Lymphoblastic Leukemia|Lymphoma, Lymphoblastic Drug: Etoposide, cytarabine, vincristine, dexamethasone|Drug: methotrexate, teniposide, PEG-asparaginase|Drug: mitoxantrone, cyclophosphamide, mercaptopurine, vinblastine|Drug: L-asparaginase, erwinia asparaginase|Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy|Procedure: Hematopoietic Stem Cell Transplant|Procedure: Natural Killer (NK) Cell Transplant St. Jude Children's Research Hospital Phase 2 2003-11-01 2016-09-21
    NCT01700946 Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood B-Lymphoblastic Lymphoma Drug: dexamethasone|Drug: vincristine sulfate|Biological: rituximab|Drug: clofarabine|Drug: cyclophosphamide|Drug: etoposide|Biological: aldesleukin|Drug: pegaspargase|Drug: methotrexate|Drug: mercaptopurine|Drug: cytarabine|Drug: mitoxantrone|Drug: teniposide|Drug: vinblastine|Biological: natural killer cell infusion|Other: laboratory biomarker analysis|Drug: therapeutic hydrocortisone|Procedure: allogeneic hematopoietic stem cell transplantation St. Jude Children's Research Hospital|Cookies for Kids' Cancer|Assisi Foundation Phase 2 2012-10-01 2016-11-29
    NCT00184041 Acute Lymphoblastic Leukemia Drug: Daunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine University of Southern California Phase 2 2004-07-01 2014-05-20
    NCT00696735 Follicular Lymphoma Procedure: chemotherapy|Procedure: high dose therapy and autologous stem cell transplantation French Innovative Leukemia Organisation Phase 3 1994-06-01 2008-10-23
    NCT02028650 Relapse Leukemia Biological: the first donor's stem cell|Biological: the second donor's stem cell huishengai|The Affiliated Hospital of the Chinese Academy of Military Medical Sciences 2005-02-01 2016-07-12
    NCT01430013 T Cell Lymphoma Drug: Endostar and CHOPT Tianjin Medical University Cancer Institute and Hospital|Simcere Pharmaceutical Co., Ltd Phase 2 2011-06-01 2015-11-02
    NCT02290132 Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma Drug: Rabbit Anti锛峢uman Thymocyte Globulin (ATG) Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine|Tang-Du Hospital|The First Affiliated Hospital of Soochow University|The First Affiliated Hospital with Nanjing Medical University Phase 4 2013-08-01 2014-11-08
    NCT01290120 Burkitt Lymphoma|B-ALL Drug: Chemotherapy-Rituximab combination Northern Italy Leukemia Group Phase 2 2002-11-01 2014-09-15
    NCT00853008 Acute Lymphoblastic Leukemia Drug: Vincristine|Drug: Daunorubicin|Drug: Prednisone|Drug: Mitoxantrone|Drug: Cytosine Arabinoside|Drug: Dexamethasone|Drug: Methotrexate (MTX)|Drug: Cytarabine|Drug: ASP|Drug: Mercaptopurine|Drug: Teniposide|Drug: Hydrocortisone PETHEMA Foundation Phase 4 2003-01-01 2017-01-11
    NCT02788201 Urothelial Carcinoma|Bladder Cancer|Urinary Bladder Neoplasms Drug: 75 approved agents|Other: COXEN National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 2 2016-05-20 2017-01-24
    NCT00187083 Acute Lymphoblastic Leukemia Drug: Topotecan, dexamethasone, vincristine|Drug: E. coli Asparaginase, PEG-L-asparaginase|Drug: erwinia asparaginase|Drug: fludarabine, methotrexate, mercaptopurine|Drug: idarubicin, etoposide, cytarbine, teniposide|Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy St. Jude Children's Research Hospital Phase 3 1997-02-01 2008-06-03
    NCT02272699 Esophageal Squamous Cell Carcinoma Drug: Nimotuzumab|Drug: Paclitaxel|Drug: Cisplatin|Radiation: Radiation|Procedure: Surgery Peking University Phase 2|Phase 3 2014-11-01 2015-12-17
    NCT01704690 Esophageal Cancer Drug: S-1 and Paclitaxel|Drug: Paclitaxel and Cisplatin|Drug: 5-FU and Cisplatin Peking University Phase 2|Phase 3 2012-08-01 2016-03-28
    NCT00343369 Leukemia Drug: asparaginase|Drug: cyclophosphamide|Drug: cytarabine|Drug: daunorubicin hydrochloride|Drug: dexamethasone|Drug: doxorubicin hydrochloride|Drug: mercaptopurine|Drug: methotrexate|Drug: pegaspargase|Drug: prednisolone|Drug: teniposide|Drug: thioguanine|Drug: vincristine sulfate|Radiation: radiation therapy Universit盲tsklinikum Hamburg-Eppendorf|National Cancer Institute (NCI) 2003-01-01 2013-08-23
    NCT00004231 Lymphoma Biological: aldesleukin|Biological: filgrastim|Biological: recombinant interferon alfa|Drug: busulfan|Drug: cyclophosphamide|Drug: cytarabine|Drug: doxorubicin hydrochloride|Drug: leucovorin calcium|Drug: methotrexate|Drug: prednisone|Drug: teniposide|Drug: vincristine sulfate|Procedure: allogeneic bone marrow transplantation|Procedure: autologous bone marrow transplantation|Procedure: peripheral blood stem cell transplantation Northwestern University|National Cancer Institute (NCI) Phase 2 1999-10-01 2012-05-31
    NCT00002531 Leukemia Drug: asparaginase|Drug: cyclophosphamide|Drug: cytarabine|Drug: daunorubicin hydrochloride|Drug: dexamethasone|Drug: doxorubicin hydrochloride|Drug: etoposide|Drug: ifosfamide|Drug: leucovorin calcium|Drug: mercaptopurine|Drug: methotrexate|Drug: mitoxantrone hydrochloride|Drug: prednisolone|Drug: teniposide|Drug: thioguanine|Drug: vincristine sulfate|Drug: vindesine|Procedure: allogeneic bone marrow transplantation|Procedure: peripheral blood stem cell transplantation|Radiation: radiation therapy Johann Wolfgang Goethe University Hospital|National Cancer Institute (NCI) Phase 2 1993-01-01 2013-09-16
    NCT02645864 Esophageal Squamous Cell Carcinoma Drug: Apatinib|Drug: Irinotecan Peking University|Jiangsu HengRui Medicine Co., Ltd. Phase 1 2016-01-01 2016-03-22
    NCT00199095 Adult Acute Lymphocytic Leukemia Drug: Adriamycin|Drug: Cyclophosphamide|Drug: Cytarabine|Drug: Dexamethasone|Drug: Idarubicin|Drug: Ifosfamide|Drug: Methotrexate|Drug: Mercaptopurine|Drug: VM26|Drug: Vincristine Johann Wolfgang Goethe University Hospital Phase 4 1997-02-01 2008-05-16
    NCT00199069 Adult Acute Lymphocytic Leukemia Drug: Asparaginase|Drug: Vincristine|Drug: Daunorubicin, Adriamycin|Drug: Cyclophosphamide|Drug: Ifosfamide|Drug: Cytarabine|Drug: Mitoxantrone|Drug: Methotrexate|Drug: 6-Mercaptopurine|Drug: 6-Thioguanine|Drug: VM26|Drug: Dexamethasone / Prednisolone|Procedure: CNS Irradiation|Procedure: Mediastinal Irradiation|Procedure: Stem Cell Transplantation Johann Wolfgang Goethe University Hospital|Deutsche Krebshilfe e.V., Bonn (Germany) Phase 4 1993-04-01 2008-05-16
    NCT00199056 Adult Acute Lymphocytic Leukemia Drug: Dexamethasone / Prednisolone|Drug: Cyclophosphamide|Drug: Methotrexate|Drug: Vincristine / Vindesine|Drug: Daunorubicin|Drug: Asparaginase|Drug: G-CSF|Drug: Cytarabine|Drug: 6-Mercaptopurine|Drug: VP16|Drug: Adriamycin|Drug: Thioguanine|Drug: VM26|Drug: Idarubicin|Drug: Fludarabine|Drug: Ifosfamide|Procedure: CNS irradiation|Procedure: Mediastinal irradiation (if residual tumor)|Procedure: stem cell transplantation Johann Wolfgang Goethe University Hospital Phase 4 1999-10-01 2008-05-16
    NCT00199004 Adult Acute Lymphocytic Leukemia Drug: Cyclophosphamide|Drug: Dexamethasone / Prednisolone|Drug: Vincristine|Drug: Daunorubicin|Drug: Asparaginase|Drug: Methotrexate|Drug: Cytarabine|Drug: Mercaptopurine|Drug: G-CSF|Drug: Vindesine|Drug: VP16|Drug: Adriamycin|Drug: Thioguanine|Drug: VM26|Drug: Rituximab|Procedure: CNS irradiation|Procedure: Mediastinal irradiation (if residual TU)|Procedure: Stem cell transplantation Johann Wolfgang Goethe University Hospital Phase 4 2004-04-01 2010-08-20
    NCT00198991 Adult Acute Lymphocytic Leukemia Drug: Cyclophosphamide|Drug: Dexamethasone|Drug: Vincristine|Drug: daunorubicin|Drug: Asparaginase|Drug: Methotrexate|Drug: Cytarabine|Drug: Mercaptopurine|Drug: G-CSF|Drug: Vindesine|Drug: VP16|Drug: Prednisolone|Drug: Adriamycin|Drug: Thioguanine|Drug: VM26|Procedure: CNS irradiation|Procedure: Mediastinal Irradiation|Procedure: Stem cell transplantation|Drug: Idarubicin|Drug: Fludarabine|Drug: Cladribine Johann Wolfgang Goethe University Hospital|Deutsche Krebshilfe e.V., Bonn (Germany)|German Federal Ministry of Education and Research Phase 4 2003-04-01 2008-05-29
    NCT02086942 Multiple Myeloma Drug: Bortezomib|Drug: cyclophosphamide|Drug: Dexamethasone Yongping Zhai|Jinling Hospital, China Phase 2 2013-08-01 2016-09-20

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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