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Nicorandil

尼可地尔,SG-75,SG 75,SG75

Nicorandil 钾离子通道活化剂。

目录号
EY0577
EY0577
纯度
99.60%
99.60%
规格
50 mg
100 mg
原价
280
520
售价
280
520
库存
现货
现货
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  • 生物活性

    Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Sato T, et al. J Am Coll Cardiol, 2000, 35(2), 514-518.
    [2] Fujiwara, Takayuki., et al., 2007. Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction. Heart and vessels. 22(5): 303-9.
    [3] Shindo, T., et al., 1998. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. British journal of pharmacology. 124(5): 985-91.
    [4] Yoneyama, F., et al., 1990. Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 4(4): 1119-26.
    [5] Carreira, Raquel S., et al., 2008. Nicorandil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion. Journal of bioenergetics and biomembranes. 40(2): 95-102.

    分子式
    C8H9N3O4    		 分子量
    211.17    		 CAS号
    65141-46-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >25 mg/mL    		 Water
    5 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01397994 Chronic Stable Angina Drug: Nicorandil|Drug: Atenolol Ferozsons Laboratories Ltd. Phase 4 2011-09-01 2011-12-07
    NCT02809456 Radiation Pneumonitis Drug: Nicorandil Taipei Medical University WanFang Hospital Phase 2 2016-07-01 2016-06-22
    NCT02328521 Angina, Unstable|Diabetes Mellitus Drug: Nicorandil|Drug: nicorandil placebo Zhang Ying Qian|Chinese PLA General Hospital Phase 4 2014-12-01 2015-01-17
    NCT02449070 Myocardial Infarction Drug: Nicorandil Pusan National University Hospital|JW Pharmaceutical Phase 3 2015-05-01 2015-05-15
    NCT01396395 Stable Angina|Coronary Disease Drug: Nicorandil|Drug: Standard Treatment Merck KGaA|Merck Serono Co., Ltd., China Phase 4 2011-09-01 2016-03-15
    NCT01475123 Coronary Artery Disease|End Stage Renal Disease Drug: Nicorandil Kumamoto University Phase 4 2008-06-01 2017-03-02
    NCT01103336 Chronic Renal Failure Drug: pretreatment with intravenous nicorandil vs. placebo before coronary angiography Yonsei University|GE Healthcare Phase 4 2010-03-01 2012-02-02
    NCT02435797 Coronary Heart Disease Drug: Nicorandil|Drug: normal saline Xuzhou Central Hospital Phase 4 2015-04-01 2015-05-05
    NCT00848562 Acute Myocardial Infarction|Congestive Heart Failure Drug: Nicorandil Toujinkai Hospital 2002-01-01 2009-02-19
    NCT03010423 Non-obstructive Coronary Artery Disease Drug: Nicorandil|Drug: Standard treatment Merck KGaA Phase 4 2016-11-01 2017-01-04
    NCT02254252 Slow Coronary Flow|Normal, or Near Normal Coronary Angiography|Stable Angina Drug: Nicorandil|Drug: Nitroglycerin Mashhad University of Medical Sciences Phase 4 2012-03-01 2015-03-28
    NCT01331902 Coronary Artery Disease|Myocardial Ischemia Other: Maximal Hyperemia with Adenosine Followed by Nicorandil|Other: Maximal Hyperemia with Nicorandil Followed by Adenosine Seoul National University Hospital|Seoul National University Boramae Hospital|Inje University|Keimyung University Dongsan Medical Center Phase 4 2011-03-01 2011-04-07
    NCT00212030 Acute Myocardial Infarction Drug: nicorandil|Drug: placebo National Cerebral and Cardiovascular Center 2001-10-01 2007-10-31
    NCT01185015 Angina Pectoris Drug: Sigmart (nicorandil) Merck KGaA Phase 4 2011-01-01 2014-07-01
    NCT02715518 Acute Myocardial Infarction Device: PCI using 2nd generation drug-eluting stent Samsung Medical Center|Seoul National University Hospital Phase 4 2016-08-01 2016-12-20
    NCT02425969 Grey-zone Fractional Flow Reserve|Intermediate Coronary Lesions|Stable Angina|Coronary Physiology Procedure: PCI|Drug: Optimal Medical Therapy Golden Jubilee National Hospital|British Heart Foundation|University of Glasgow 2015-04-01 2017-03-02
    NCT00424801 Microvascular Angina|Hypertension Drug: Lercanidipine|Drug: Valsartan|Drug: Nicorandil|Drug: Doxazosin|Drug: Moxonidin|Drug: Pindolol|Drug: Amiloride, hydrochlorothiazide University of Aarhus|Danish Cardiovascular Research Academy|Danish Heart Foundation|Novartis 2007-01-01 2009-05-05

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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