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Rivaroxaban

利伐沙班,BAY 59-7939

Rivaroxaban是一种口服具有直接作用的Factor Xa抑制剂,Ki值为0.4 nM,IC50值为0.7 nM。

目录号
EY0575
EY0575
EY0575
纯度
99.62%
99.62%
99.62%
规格
5 mg
10 mg
50 mg
原价
620
910
1750
售价
620
910
1750
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Rivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0 -100 μM

  • 动物实验

    静脉注射≤0.3 mg/kg 口服 ≤3 mg/kg 静脉注射或口服

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Perzborn E, et al. J Thromb Haemost, 2005, 3(3), 514–521.
    [2] Eriksson, B.I., et al. 2005. J. Thromb. Haemost. 3: 103-111
    [3] Ansell, J., et al. 2004. Drugs. 64: 1-5.
    [4] Kubitza, D., et al. 2005. Clin. Pharmacol. Ther. 78: 412-421.

    分子式
    C19H18ClN3O5S
    分子量
    88
    CAS号
    366789-02-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >68 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02047006 Chronic Renal Failure Drug: Rivaroxaban 10 mg AZ Sint-Jan AV|Onze Lieve Vrouw Hospital Phase 4 2013-09-01 2015-01-13
    NCT02486445 Deep Venous Thrombosis Drug: Rivaroxaban Ostfold Hospital Trust Phase 3 2015-02-01 2016-10-10
    NCT02970773 Spinal Cord Injuries|Thromboembolism Drug: Rivaroxaban Swiss Paraplegic Centre Nottwil 2017-01-01 2016-11-18
    NCT01598168 Heparin-induced Thrombocytopenia Drug: Rivaroxaban McMaster University Phase 3 2013-01-01 2016-03-24
    NCT02583191 Venous Thromboembolism|Cancer Drug: Rivaroxaban|Drug: low-molecular heparine AIO-Studien-gGmbH|Charite University, Berlin, Germany|Bayer Phase 3 2016-03-01 2016-03-18
    NCT01989845 Rivaroxaban|Cancer-associated Thrombosis|Recurrence|Bleeding Drug: Rivaroxaban Seoul National University Hospital|Korean Society of Hematology Thrombosis Working Party Phase 4 2013-10-01 2017-01-06
    NCT02438098 Prophylaxis of Venous Thromboembolism Drug: Rivaroxaban 10 mg University Hospital Inselspital, Berne|Centre Hospitalier Universitaire Vaudois|Bayer Phase 1 2015-06-01 2016-01-07
    NCT02657512 Healthy Drug: rivaroxaban|Drug: rivaroxaban and activated charcoal Centre Hospitalier Universitaire de Saint Etienne Phase 1 2016-01-01 2016-05-24
    NCT02116036 Antiphospholipid Antibody Syndrome Drug: Rivaroxaban St. Joseph's Healthcare Hamilton|Heart and Stroke Foundation of Canada|Bayer|Hamilton Health Sciences Corporation|Jewish General Hospital|University of Alberta|The Ottawa Hospital|Queen Elizabeth II Health Sciences Centre Phase 4 2014-09-01 2015-07-23
    NCT02072668 Sickle Cell Anemia|Sickle Cell-Beta0-Thalassemia Drug: rivaroxaban|Drug: placebo University of North Carolina, Chapel Hill|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2014-02-01 2016-11-02
    NCT02157272 Antiphospholipid Syndrome Drug: Experimental: Rivaroxaban University of Padova Phase 3 2014-12-01 2015-11-30
    NCT02066662 Atrial Fibrillation or Pulmonary Embolism|Need of Long Term Oral Anticoagulation Therapy (OAT)|Existent Coronary or Valvular Calcification, or Both and Agatston Score > 50 in at Least One Location Drug: Rivaroxaban or Marcumar RWTH Aachen University|Bayer Phase 4 2013-07-01 2015-12-03
    NCT02289703 End-Stage Renal Disease Drug: Rivaroxaban 15 mg Janssen Research & Development, LLC|Bayer Phase 1 2015-01-01 2017-01-23
    NCT02333929 Patients Receiving Rivaroxaban Treatment Device: STA- Rivaroxaban Calibrator&Control Diagnostica Stago 2015-03-01 2017-02-13
    NCT01708850 Neoplasm|Central Venous Catheter Thrombosis Drug: Rivaroxaban London Health Sciences Centre Phase 4 2012-11-01 2016-09-06
    NCT02042534 Ischemic Stroke|Transient Ischemic Attack Drug: Rivaroxaban|Drug: Warfarin Asan Medical Center|Bayer Phase 2 2014-01-01 2016-12-14
    NCT01747746 Atrial Fibrillation|Stroke|Thrombo-embolism|Bleeding Drug: Rivaroxaban|Drug: Warfarin and Enoxaparin John H. Stroger Hospital|Cook County Hospital Phase 4 2012-10-01 2015-02-02
    NCT02058199 Gastric Bypass Status Drug: rivaroxaban State University of New York - Upstate Medical University Phase 1 2014-12-01 2016-01-04
    NCT02468102 Acute Coronary Syndrome Drug: Rivaroxaban (Xarelto, BAY59-7939)|Drug: Standard of care drugs Bayer|Janssen Scientific Affairs, LLC 2015-06-01 2017-03-13
    NCT02926170 Antiphospholipid Syndrome Drug: Rivaroxaban|Drug: acenocumarol Hospital Universitari Vall d'Hebron Research Institute Phase 3 2013-03-01 2016-10-05

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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