Home > others & > Clotrimazole

Clotrimazole

克霉唑,BAY b 5097,FB 5097, CLT,Canesten,Lotrimin,FB5097,FB-5097,

Clotrimazole是咪唑衍生物，有抗真菌活性，是P450抑制剂。

目录号
EY0569
EY0569
纯度
99.68%
99.68%
规格
100 mg
500 mg
原价
280
490
售价
280
490
库存
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Clotrimazole alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections [1].

    Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51) [2]. The demethylated products of the CYP51 reaction are vital intermediates in pathways leading to the formation of cholesterol in humans, ergosterol in fungi, and other types of sterols in plants (Lepesheva et al.).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Aktas H, et al. Proc Natl Acad Sci U S A,?998, 95(14), 8280-8285.
    [2] Appl Environ Microbiol. 2014 Oct;80(19):6154-66. doi: 10.1128/AEM.01195-14.
    [3] Jensen, B.S., et al. 2001. Curr Drug Targets. 2: 401-422.
    [4] Carrillo-Muñoz, A.J., et al. 2002. Int. J. Antimicrob. Agents. 20: 375-379.

    分子式
    C22H17ClN2    		 分子量
    344.84    		 CAS号
    23593-75-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    10 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    66 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00835029 Oral Candidiasis|Denture Stomatitis Drug: Clotrimazole varnish|Drug: Clotrimazole troches Hadassah Medical Organization Phase 2 2009-03-01 2015-03-24
    NCT01547221 Otomycosis Drug: clotrimazole|Drug: 3% Boric acid Khon Kaen Hospital 2012-03-01 2015-04-27
    NCT02180828 Candidiasis, Vulvovaginal Drug: Clotrimazole vaginal tablet|Drug: Fluconazole Peking University Shenzhen Hospital|Bayer Phase 4 2014-07-01 2016-08-08
    NCT01697826 Vaginal Infections Drug: ClinSupV3 -soft gelatin capsule|Drug: ClinSupV3ER- Extended release tablet Dr Bharti Daswani|Resilient Cosmeceuticals Pvt. Ltd, Pune|Daswani, Bhart, M.D. Phase 4 2011-04-01 2012-10-01
    NCT02847286 HIV- Prevention Drug: Dapivirine Ring-004|Drug: Dapivirine Ring-004 for 28 days along with clotrimazole|Drug: Clotrimazole International Partnership for Microbicides, Inc. Phase 1 2015-09-01 2016-12-16
    NCT00755053 Clotrimazole|Ovulen|Vulvovaginal Candidiasis Drug: Clotrimazole, vaginal ovule|Drug: Clotrimazole, vaginal tablet Bayer Phase 3 2008-09-01 2015-08-04
    NCT02184351 Candidiasis, Oral Drug: Roxanes's clotrimazole troches|Drug: Mycelex庐 troches Boehringer Ingelheim Phase 3 2001-05-01 2014-07-11
    NCT02907307 Vulvovaginal Candidiasis Device: LactiSal vaginal gel 1%|Device: LactiSal vaginal tablet 50mg|Drug: Clotrimazole vaginal tablet 100mg Medinova AG Phase 3 2017-05-01 2016-09-14
    NCT00002282 Candidiasis, Oral|HIV Infections Drug: Clotrimazole|Drug: Fluconazole Pfizer|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT02713139 Sexual Active Women|Vaginal Discharge Drug: Clotrimazole + Metronidazole|Drug: Metronidazole|Drug: Clotrimazole Ache Laboratorios Farmaceuticos S.A. Phase 3 2013-09-01 2016-03-15
    NCT01244256 Folliculitis Drug: Clotrimazole + Gentamicin + Beclomethasone|Drug: Clotrimazole + Gentamicin Azidus Brasil Phase 2|Phase 3 2007-04-01 2010-11-18
    NCT02635438 Oropharyngeal Candidiasis Drug: Unique Pharmaceutical Laboratories, India|Drug: Roxane Laboratories Inc., USA Thinq Pharma-CRO Pte. Ltd.|Unique Pharmaceuticals Ltd, India|THINQ Pharma CRO Ltd. Phase 3 2016-12-01 2016-12-22
    NCT00000676 Candidiasis|Mycoses|HIV Infections Drug: Clotrimazole|Drug: Fluconazole National Institute of Allergy and Infectious Diseases (NIAID)|Pfizer Phase 3 null 2012-03-28
    NCT01993823 Otomycosis Drug: G238|Drug: Clotrimazole Salvat Phase 3 2013-05-01 2016-12-21
    NCT00390780 HIV Infections Drug: miconazole Lauriad|Drug: Clotrimazole Onxeo Phase 3 2006-07-01 2013-09-05
    NCT02242695 Vulvovaginal Candidiasis Drug: Fluomizin vaginal tablets|Drug: Canesten vaginal tablets Medinova AG|Mahidol University Phase 4 2014-11-01 2016-09-14
    NCT02248506 Candidiasis, Vulvovaginal Other: Clotrimazole Instituto Palacios|GYNEA Laboratorios S. L. Phase 4 2013-06-01 2015-03-24
    NCT02582177 Tinea Drug: Ketoconazole + betamethasone dipropionate|Drug: Clotrimazole + Dexamethasone acetate Ache Laboratorios Farmaceuticos S.A. Phase 3 2017-08-01 2017-02-14
    NCT00004492 Sickle Cell Anemia Drug: clotrimazole|Drug: hydroxyurea University of North Carolina|FDA Office of Orphan Products Development Phase 1|Phase 2 1999-10-01 2015-03-24
    NCT00671528 Dermatitis, Atopic|Eczema, Atopic|Skin Diseases, Eczematous Drug: Cream (betamethasone diproprionate, clotrimazole, and gentamicin sulfate)|Drug: Cream (betamethasone diproprionate and gentamicin)|Drug: Cream (betamethasone diproprionate) Merck Sharp & Dohme Corp. Phase 4 2009-07-01 2014-12-29
    NCT00629122 Kidney Failure, Chronic Drug: Tacrolimus/Clotrimazole Troche|Drug: Tacrolimus/Nystatin Suspension Weill Medical College of Cornell University Phase 4 2008-02-01 2010-11-04
    NCT03026478 Oral Lichen Planus Drug: Betamethasone Dipropionate|Drug: Clobetasol Propionate Garlapati Komali|Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre Phase 2 2016-05-01 2017-01-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：