Argatroban是凝血酶选择性抑制剂。
Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Berry CN, et al. Br J Pharmacol,?994, 113(4), 1209-1214.
分子式 C23H36N6O5S |
分子量 508.63 |
CAS号 74863-84-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 25 mg/mL |
Water 1 mg/mL |
Ethanol 25 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01980316 | CVD | Drug: Argatroban|Drug: non-argatroban treated group | Xinfeng Liu|Jinling Hospital, China | Phase 4 | 2010-04-01 | 2015-10-21 |
NCT00268762 | Ischemic Stroke | Drug: argatroban | The University of Texas Health Science Center, Houston | Phase 1|Phase 2 | 2003-02-01 | 2014-11-03 |
NCT02448069 | Stroke|Cerebral Ischemia | Drug: Argatroban | The University of Texas Health Science Center, Houston | Phase 2 | 2015-05-01 | 2015-05-28 |
NCT01734252 | Achievement of a Sufficient Thrombosis Prohpylaxis in Clitically Ill Patients With Heparin Resistance | Drug: Argatroban | Medical University Innsbruck | Phase 2 | 2012-06-01 | 2015-04-16 |
NCT00861692 | Heparin-induced Thrombocytopenia Type II | Drug: argatroban | Mitsubishi Tanabe Pharma Corporation | Phase 2 | 2009-04-01 | 2016-07-01 |
NCT01163604 | CVD | Drug: Argatroban|Drug: non-argatroban treated group | Jinling Hospital, China | Phase 4 | 2010-08-01 | 2015-10-21 |
NCT01246011 | Coronary Artery Bypass Graft Surgery|Presence of Heparin/Platelet Factor 4 Antibody | Drug: Argatroban and warfarin | Massachusetts General Hospital|GlaxoSmithKline | Phase 4 | 2010-11-01 | 2012-03-09 |
NCT00798525 | Heparin Induced Thrombocytopenia (HIT) | Drug: Argatroban|Drug: Lepirudin | Heinrich-Heine University, Duesseldorf | Phase 4 | 2009-01-01 | 2012-06-20 |
NCT00787332 | Suspected Heparin-Induced Thrombocytopenia | Drug: Desirudin or Argatroban庐 | Canyon Pharmaceuticals, Inc. | Phase 4 | 2008-09-01 | 2013-01-06 |
NCT01464788 | Ischemic Stroke | Drug: Argatroban|Drug: Argatroban | Andrew D. Barreto, MD|The University of Texas Health Science Center, Houston | Phase 2 | 2011-10-01 | 2015-05-11 |
NCT00198588 | Heparin-Induced Thrombocytopenia | Drug: argatroban | Ministry of Health, Labour and Welfare, Japan|Mitsubishi Tanabe Pharma Corporation | Phase 3 | 2005-06-01 | 2008-11-11 |
NCT00035178 | Kidney Failure, Chronic|Renal Disease, End-Stage | Drug: Argatroban | Texas Biotechnology Corporation|Encysive Pharmaceuticals | Phase 4 | 2002-05-01 | 2005-06-23 |
NCT00039858 | Thrombocytopenia|Thrombosis | Drug: Argatroban | Encysive Pharmaceuticals|GlaxoSmithKline | Phase 4 | 2003-09-01 | 2007-01-10 |
NCT00508924 | Coronary Artery Disease|Angina, Unstable | Drug: Argatroban|Drug: Argatroban|Drug: Argatroban|Drug: Heparin | Mitsubishi Tanabe Pharma Corporation | Phase 2 | 2005-08-01 | 2012-11-06 |
NCT00153946 | Stroke | Drug: Edaravone | Combination Therapy for Acute Ischemic Stroke Study Group|Japan Cardiovascular Research Foundation | Phase 4 | 2004-08-01 | 2008-05-12 |
NCT01304238 | Acute HIT II (Heparin-induced Thrombocytopenia Type II) | Drug: lepirudin|Drug: danaparoid|Drug: argatroban|Drug: fondaparinux | GlaxoSmithKline | 2009-02-01 | 2011-03-10 | |
NCT02935530 | Gynecologic Neoplasms|Venous Thromboembolism|Low Molecular Weight Heparin|Argatroban | Drug: s-LMWH|Drug: LMWH|Drug: Argatroban | Huazhong University of Science and Technology | Phase 3 | 2016-01-01 | 2016-10-14 |
NCT01162824 | Endothelial Dysfunction|Atherosclerosis|Inflammation|Myocardial Ischemia | Drug: Acetylcholine|Drug: Adenosine | St George's Healthcare NHS Trust | 2011-01-01 | 2011-02-22 | |
NCT00921856 | Coronary Vasospasm|Microvascular Angina|Coronary Artery Disease | Other: Intracoronary acetylcholine provocation test | Peter Ong, MD|Robert Bosch Medical Center | 2007-11-01 | 2015-11-02 | |
NCT01911624 | Staphylococcus Aureus Bacteraemia | Drug: direct thrombin inhibition|Drug: enoxaparin | Universitaire Ziekenhuizen Leuven | Phase 2 | 2013-01-01 | 2016-07-11 |
NCT00603824 | Heparin-Induced Thrombocytopenia | Drug: fondaparinux|Drug: argatroban or lepirudin | Methodist Healthcare|University of Tennessee | Phase 4 | 2008-01-01 | 2016-09-12 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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