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Argatroban

阿加曲班,MCI-9038

Argatroban是凝血酶选择性抑制剂。

目录号
EY0567
EY0567
EY0567
EY0567
纯度
99.34%
99.34%
99.34%
99.34%
规格
5 mg
10 mg
25 mg
50 mg
原价
390
660
1200
1800
售价
390
660
1200
1800
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Berry CN, et al. Br J Pharmacol,?994, 113(4), 1209-1214.

    分子式
    C23H36N6O5S
    分子量
    508.63
    CAS号
    74863-84-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    25 mg/mL
    Water
    1 mg/mL
    Ethanol
    25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01980316 CVD Drug: Argatroban|Drug: non-argatroban treated group Xinfeng Liu|Jinling Hospital, China Phase 4 2010-04-01 2015-10-21
    NCT00268762 Ischemic Stroke Drug: argatroban The University of Texas Health Science Center, Houston Phase 1|Phase 2 2003-02-01 2014-11-03
    NCT02448069 Stroke|Cerebral Ischemia Drug: Argatroban The University of Texas Health Science Center, Houston Phase 2 2015-05-01 2015-05-28
    NCT01734252 Achievement of a Sufficient Thrombosis Prohpylaxis in Clitically Ill Patients With Heparin Resistance Drug: Argatroban Medical University Innsbruck Phase 2 2012-06-01 2015-04-16
    NCT00861692 Heparin-induced Thrombocytopenia Type II Drug: argatroban Mitsubishi Tanabe Pharma Corporation Phase 2 2009-04-01 2016-07-01
    NCT01163604 CVD Drug: Argatroban|Drug: non-argatroban treated group Jinling Hospital, China Phase 4 2010-08-01 2015-10-21
    NCT01246011 Coronary Artery Bypass Graft Surgery|Presence of Heparin/Platelet Factor 4 Antibody Drug: Argatroban and warfarin Massachusetts General Hospital|GlaxoSmithKline Phase 4 2010-11-01 2012-03-09
    NCT00798525 Heparin Induced Thrombocytopenia (HIT) Drug: Argatroban|Drug: Lepirudin Heinrich-Heine University, Duesseldorf Phase 4 2009-01-01 2012-06-20
    NCT00787332 Suspected Heparin-Induced Thrombocytopenia Drug: Desirudin or Argatroban庐 Canyon Pharmaceuticals, Inc. Phase 4 2008-09-01 2013-01-06
    NCT01464788 Ischemic Stroke Drug: Argatroban|Drug: Argatroban Andrew D. Barreto, MD|The University of Texas Health Science Center, Houston Phase 2 2011-10-01 2015-05-11
    NCT00198588 Heparin-Induced Thrombocytopenia Drug: argatroban Ministry of Health, Labour and Welfare, Japan|Mitsubishi Tanabe Pharma Corporation Phase 3 2005-06-01 2008-11-11
    NCT00035178 Kidney Failure, Chronic|Renal Disease, End-Stage Drug: Argatroban Texas Biotechnology Corporation|Encysive Pharmaceuticals Phase 4 2002-05-01 2005-06-23
    NCT00039858 Thrombocytopenia|Thrombosis Drug: Argatroban Encysive Pharmaceuticals|GlaxoSmithKline Phase 4 2003-09-01 2007-01-10
    NCT00508924 Coronary Artery Disease|Angina, Unstable Drug: Argatroban|Drug: Argatroban|Drug: Argatroban|Drug: Heparin Mitsubishi Tanabe Pharma Corporation Phase 2 2005-08-01 2012-11-06
    NCT00153946 Stroke Drug: Edaravone Combination Therapy for Acute Ischemic Stroke Study Group|Japan Cardiovascular Research Foundation Phase 4 2004-08-01 2008-05-12
    NCT01304238 Acute HIT II (Heparin-induced Thrombocytopenia Type II) Drug: lepirudin|Drug: danaparoid|Drug: argatroban|Drug: fondaparinux GlaxoSmithKline 2009-02-01 2011-03-10
    NCT02935530 Gynecologic Neoplasms|Venous Thromboembolism|Low Molecular Weight Heparin|Argatroban Drug: s-LMWH|Drug: LMWH|Drug: Argatroban Huazhong University of Science and Technology Phase 3 2016-01-01 2016-10-14
    NCT01162824 Endothelial Dysfunction|Atherosclerosis|Inflammation|Myocardial Ischemia Drug: Acetylcholine|Drug: Adenosine St George's Healthcare NHS Trust 2011-01-01 2011-02-22
    NCT00921856 Coronary Vasospasm|Microvascular Angina|Coronary Artery Disease Other: Intracoronary acetylcholine provocation test Peter Ong, MD|Robert Bosch Medical Center 2007-11-01 2015-11-02
    NCT01911624 Staphylococcus Aureus Bacteraemia Drug: direct thrombin inhibition|Drug: enoxaparin Universitaire Ziekenhuizen Leuven Phase 2 2013-01-01 2016-07-11
    NCT00603824 Heparin-Induced Thrombocytopenia Drug: fondaparinux|Drug: argatroban or lepirudin Methodist Healthcare|University of Tennessee Phase 4 2008-01-01 2016-09-12

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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