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Pentamidine

戊烷脒,MP-601205,MP601205,MP 601205

Pentamidine双盐酸盐是抗菌剂，是一种 PRL Phosphatases 抑制剂，也可以抑制DNA， RNA和蛋白质的合成。

目录号
EY0554
EY0554
纯度
99.35%
99.35%
规格
50 mg
100 mg
原价
280
388
售价
280
388
库存
现货
现货
订购
订购
订购
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  • 生物活性

    Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0.1-10微克/毫升

  • 动物实验

    0.25毫克每2周臀部肌肉注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Sands M, et al. Rev Infect Dis, 1985, 7(5), 625-634.
    [2] Pathak, M.K., et al., Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther, 2002. 1(14): p. 1255-64.

    分子式
    C19H24N4O2.2HCl    		 分子量
    413.34    		 CAS号
    50357-45-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    10 mM    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02669706 Hematologic Malignancy Drug: Pentamidine University of Illinois at Chicago Phase 2 2015-03-01 2016-06-29
    NCT02210182 Hepatocellular Carcinoma Drug: Oral Pentamidine|Other: Placebo Oncozyme Pharma Inc. Phase 1 2014-08-01 2016-03-11
    NCT00810953 Pancreatic Cancer Drug: Pentamidine Oncozyme Pharma Inc. Phase 1|Phase 2 2009-01-01 2011-06-27
    NCT00809796 Colorectal Cancer Drug: pentamidine Oncozyme Pharma Inc. Phase 1|Phase 2 2008-03-01 2011-06-27
    NCT00002053 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate Fisons|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00002292 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate LyphoMed|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00002030 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate Fisons|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00000974 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2012-03-28
    NCT00002054 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate Fisons|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00001027 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate National Institute of Allergy and Infectious Diseases (NIAID)|Fujisawa Pharmaceutical Co Phase 1 null 2012-03-28
    NCT00000722 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate National Institute of Allergy and Infectious Diseases (NIAID) null 2012-03-28
    NCT00002291 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate Fisons|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00729807 Melanoma (Skin) Drug: pentamidine|Genetic: gene expression analysis|Genetic: polymerase chain reaction|Genetic: western blotting|Other: bioluminescence|Other: immunoenzyme technique|Other: immunohistochemistry staining method|Other: laboratory biomarker analysis Edward Sausville|National Cancer Institute (NCI)|University of Maryland Phase 2 2008-07-01 2016-08-30
    NCT00002055 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate Fisons|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00000707 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate National Institute of Allergy and Infectious Diseases (NIAID) null 2012-03-28
    NCT00002056 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate LyphoMed|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00001028 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate|Drug: Dapsone National Institute of Allergy and Infectious Diseases (NIAID)|Jacobus Pharmaceutical|Fujisawa Pharmaceutical Co Phase 3 null 2012-03-28
    NCT00001003 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Pentamidine isethionate|Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) null 2012-03-28
    NCT00002340 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone|Drug: Pentamidine isethionate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 3 null 2005-06-23
    NCT00001996 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone|Drug: Pentamidine isethionate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 2 null 2005-06-23

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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