Piperine

胡椒碱,1-Piperoylpiperidine

Piperine是一种生物碱,是造成黑胡椒和长胡椒辛辣的原因,也用于一些传统医学领域,且作为杀虫剂。

目录号
EY0553
EY0553
纯度
99.16%
99.16%
规格
1 g
5 g
原价
168.00
298.00
售价
168.00
298.00
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Bhardwaj RK, et al. J Pharmacol Exp Ther, 2002, 302(2), 645-650.
    [2] Selvendiran K, Senthilnathan P, Magesh V et al. Phytomedicine. 11:85-9 (2004).
    [3] Sunila ES, Kuttan G. J Ethnopharmacol. 90:339-46 (2004).
    [4] Mittal R, Gupta RL. Methods Find Exp Clin Pharmacol. 22:271-4 (2000).

    分子式
    C17H19NO3
    分子量
    285.34
    CAS号
    94-62-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    57 mg/mL
    Water
    <1 mg/mL
    Ethanol
    57 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02598726 Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency Drug: Curcumin|Other: Laboratory Biomarker Analysis|Dietary Supplement: Piperine Extract (Standardized)|Other: Quality-of-Life Assessment Mayo Clinic|National Cancer Institute (NCI) Phase 1 2016-03-01 2016-12-20
    NCT01324089 Focus of the Study: Normal Volunteers Dietary Supplement: Resveratrol|Dietary Supplement: Resveratrol 2.5 grams x 1 dose and Piperine 5 mg x 1 dose|Dietary Supplement: Resveratrol 2.5 grams x 1 dose and Piperine 25 mg x 1 dose University of Wisconsin, Madison|National Institutes of Health (NIH)|National Cancer Institute (NCI) 2011-03-01 2013-05-31
    NCT01331382 Healthy Dietary Supplement: Trans- resveratrol|Other: Placebo (silica) Northumbria University 2010-04-01 2011-04-07
    NCT01893424 Pain Drug: Sativex buccal spray|Drug: CBD-THC-Piperine-PNL capsule Hadassah Medical Organization Phase 1 2013-08-01 2016-03-23
    NCT00181662 Healthy Drug: Curcumin Massachusetts General Hospital 2005-08-01 2007-04-02
    NCT01729143 Obesity Other: 24-hour energy expenditure and substrate utilization University of North Carolina, Chapel Hill|Appalachian State University 2011-04-01 2016-04-05
    NCT01288859 Healthy Other: free curcumin|Other: encapsulated curcumin|Other: encapsulated curcumin + PQG|Other: free cocoa polyphenol|Other: encapsulated cocoa polyphenols|Other: control nut cream Federico II University 2010-12-01 2012-07-31
    NCT02542449 Obesity Dietary Supplement: Globes庐|Dietary Supplement: Placebo Istituto Auxologico Italiano Phase 4 2013-04-01 2015-09-04
    NCT01640197 Healthy Dietary Supplement: Resveratrol|Other: Placebo Northumbria University|Biotivia Longevity Bioceuticals Phase 1 2011-02-01 2012-10-17
    NCT00065741 HIV Seronegativity Drug: silymarin National Center for Complementary and Integrative Health (NCCIH) Phase 1 2003-09-01 2007-03-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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