Piperine是一种生物碱,是造成黑胡椒和长胡椒辛辣的原因,也用于一些传统医学领域,且作为杀虫剂。
Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Bhardwaj RK, et al. J Pharmacol Exp Ther, 2002, 302(2), 645-650.
[2] Selvendiran K, Senthilnathan P, Magesh V et al. Phytomedicine. 11:85-9 (2004).
[3] Sunila ES, Kuttan G. J Ethnopharmacol. 90:339-46 (2004).
[4] Mittal R, Gupta RL. Methods Find Exp Clin Pharmacol. 22:271-4 (2000).
分子式 C17H19NO3 |
分子量 285.34 |
CAS号 94-62-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 57 mg/mL |
Water <1 mg/mL |
Ethanol 57 mg/mL |
体内溶解度
NCT02598726 | Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency | Drug: Curcumin|Other: Laboratory Biomarker Analysis|Dietary Supplement: Piperine Extract (Standardized)|Other: Quality-of-Life Assessment | Mayo Clinic|National Cancer Institute (NCI) | Phase 1 | 2016-03-01 | 2016-12-20 |
NCT01324089 | Focus of the Study: Normal Volunteers | Dietary Supplement: Resveratrol|Dietary Supplement: Resveratrol 2.5 grams x 1 dose and Piperine 5 mg x 1 dose|Dietary Supplement: Resveratrol 2.5 grams x 1 dose and Piperine 25 mg x 1 dose | University of Wisconsin, Madison|National Institutes of Health (NIH)|National Cancer Institute (NCI) | 2011-03-01 | 2013-05-31 | |
NCT01331382 | Healthy | Dietary Supplement: Trans- resveratrol|Other: Placebo (silica) | Northumbria University | 2010-04-01 | 2011-04-07 | |
NCT01893424 | Pain | Drug: Sativex buccal spray|Drug: CBD-THC-Piperine-PNL capsule | Hadassah Medical Organization | Phase 1 | 2013-08-01 | 2016-03-23 |
NCT00181662 | Healthy | Drug: Curcumin | Massachusetts General Hospital | 2005-08-01 | 2007-04-02 | |
NCT01729143 | Obesity | Other: 24-hour energy expenditure and substrate utilization | University of North Carolina, Chapel Hill|Appalachian State University | 2011-04-01 | 2016-04-05 | |
NCT01288859 | Healthy | Other: free curcumin|Other: encapsulated curcumin|Other: encapsulated curcumin + PQG|Other: free cocoa polyphenol|Other: encapsulated cocoa polyphenols|Other: control nut cream | Federico II University | 2010-12-01 | 2012-07-31 | |
NCT02542449 | Obesity | Dietary Supplement: Globes庐|Dietary Supplement: Placebo | Istituto Auxologico Italiano | Phase 4 | 2013-04-01 | 2015-09-04 |
NCT01640197 | Healthy | Dietary Supplement: Resveratrol|Other: Placebo | Northumbria University|Biotivia Longevity Bioceuticals | Phase 1 | 2011-02-01 | 2012-10-17 |
NCT00065741 | HIV Seronegativity | Drug: silymarin | National Center for Complementary and Integrative Health (NCCIH) | Phase 1 | 2003-09-01 | 2007-03-21 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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