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Ezetimibe

依泽替米贝,依替米贝,SCH-58235,SCH 58235,SCH58235

Ezetimibe是胆固醇吸收抑制剂，能降低LDL胆固醇的水平。

目录号
EY0547
EY0547
EY0547
EY0547
EY0547
纯度
99.24%
99.24%
99.24%
99.24%
99.24%
规格
1 mg
5 mg
10 mg
50 mg
100 mg
原价
115
230
378
685
990
售价
115
230
378
685
990
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Ezetimibe is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Clader JW, et al. J Med Chem, 2004, 47(1), 1-9.
    [2] Ge, L., et al. 2008. Cell Metab. 7: 508-519.
    [3] Ikeda, S. and Maemura, K. 2011. Curr Vasc Pharmacol. 9: 87-98.

    分子式
    C24H21F2NO3    		 分子量
    409.43    		 CAS号
    163222-33-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    82 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    82 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00762229 Hypercholesterolemia Drug: Ezetimibe 10 mg|Drug: Ezetimibe 5 mg Bronx VA Medical Center 2007-07-01 2013-06-12
    NCT00794677 Hypercholesterolemia Drug: ezetimibe Children's Hospital & Research Center Oakland|Merck Schering-Plough Phase 4 2006-06-01 2009-07-31
    NCT00651274 Atherosclerosis|Hypercholesterolemia|Coronary Heart Disease Drug: Ezetimibe|Drug: Placebo Merck Sharp & Dohme Corp. Phase 4 2003-04-01 2015-04-15
    NCT00634140 Chronic Acalculous Cholecystitis Drug: ezetimibe|Drug: Placebo Indiana University 2009-08-01 2015-03-27
    NCT00202904 Hypercholesterolemia|Coronary Heart Disease Drug: ezetimibe|Drug: placebo Merck Sharp & Dohme Corp. Phase 4 2005-05-01 2015-04-28
    NCT00621699 Pharmacokinetics|Drug Interactions|Hypercholesterolemia|Immunosuppression Drug: 1 tablet Ezetrol(R) (ezetimibe), MSD Sharp & Dohme GmbH, Germany|Drug: 1 capsule Prograf(R) (tacrolimus), Astellas Pharma GmbH, Germany|Drug: 1 tablet Ezetrol(R) + 1 capsules Prograf(R) University Medicine Greifswald Phase 1 2007-09-01 2008-02-12
    NCT00621101 Pharmacokinetics|Drug Interactions|Hypercholesterolemia|Immunosuppression Drug: 1 tablet Ezetrol(R) (ezetimibe), MSD Sharp & Dohme GmbH, Germany|Drug: 1 tablet Rapamune(R) (sirolimus), Wyeth Pharma, Germany|Drug: 1 tablet Ezetrol(R) + 1 tablet Rapamune(R) University Medicine Greifswald Phase 1 2007-04-01 2008-02-12
    NCT00653523 Hypercholesterolemia Drug: Ezetimibe|Drug: Simvastatin Merck Sharp & Dohme Corp. Phase 3 2007-12-01 2015-06-09
    NCT00654095 Hypercholesterolemia Drug: Ezetimibe|Drug: atorvastatin Merck Sharp & Dohme Corp. Phase 3 2007-12-01 2015-06-09
    NCT00653445 Hypercholesterolemia|Coronary Heart Disease|Atherosclerosis Drug: Rosuvastatin|Drug: Ezetimibe AstraZeneca Phase 3 2004-06-01 2009-03-25
    NCT00704535 Primary Hypercholesterolemia|Homozygous Familial Hypercholesterolemia Drug: Ezetimibe Merck Sharp & Dohme Corp. 2006-03-01 2015-04-09
    NCT02029625 Dyslipidemia Drug: NVP-1205|Drug: rosuvastatin and ezetimibe Navipharm Corporation Phase 1 2014-02-01 2016-03-24
    NCT00908011 Hypercholesterolemia|HIV Infections Drug: Ezetimibe|Drug: Rosuvastatin (standard care) University of British Columbia|Merck Frosst-Schering Pharma, G.P. 2009-06-01 2015-11-30
    NCT00738985 Cardiovascular Diseases|Hyperlipidemia Drug: ezetimibe/simvastatin 10/20 mg + placebo|Drug: ezetimibe/simvastatin 10/20 mg + MK0524A Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran|Merck Sharp & Dohme Corp. Phase 4 2009-11-01 2015-03-23
    NCT00867165 Primary Hypercholesterolemia Drug: ezetimibe|Drug: Placebo Merck Sharp & Dohme Corp. Phase 3 2009-05-01 2015-04-20
    NCT02548936 Atherosclerosis Drug: Ezetimibe+Simvastatin Drug Combination Peking Union Medical College Hospital Early Phase 1 2015-04-01 2015-09-11
    NCT00319449 Hypercholesterolemia|Coronary Arteriosclerosis Drug: Ezetimibe|Drug: Placebo|Drug: Atorvastatin 10 mg Merck Sharp & Dohme Corp.|PT. Schering-Plough. Tbk Indonesia Phase 4 2005-09-01 2015-10-09
    NCT01384058 Diabetes Mellitus Type 2|Hypercholesterolemia Drug: ezetimibe|Drug: simvastatin|Drug: Ezetimibe 10/Simvastatin 20 University Hospital Freiburg|Essex Pharma GmbH Phase 4 2007-11-01 2012-06-18
    NCT00653913 Hypercholesterolemia Drug: SCH 58235|Drug: pitavastatin Merck Sharp & Dohme Corp. Phase 1 2004-03-01 2015-04-07
    NCT02682680 Type 2 Diabetes Mellitus Drug: Colesevelam|Drug: Ezetimibe LMC Diabetes & Endocrinology Ltd.|Valeant Pharmaceuticals International, Inc. Phase 4 2016-01-01 2016-02-10
    NCT01008345 Coronary Artery Disease|Diabetes Drug: ezetimibe Hotel Dieu de France Hospital|Pharmaline, Lebanon Phase 4 2008-09-01 2009-11-05

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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