Estriol

雌激素三醇,NSC-12169,Oestriol,NSC 12169,NSC12169,

Estriol是G蛋白偶联雌激素受体拮抗剂,可作用于雌激素受体阴性乳腺癌细胞。

目录号
EY0541
EY0541
EY0541
纯度
99.77%
99.77%
99.77%
规格
50 mg
100 mg
500 mg
原价
200
380
790
售价
200
380
790
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    100 nM

  • 动物实验

    4 μg/g/day 皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Lappano R, et al. Mol Cell Endocrinol. 2010, 320(1-2), 162-170.
    [2] Dessole, S., et al. 2004. Menopause. 11: 49-56.
    [3] Luo, X.H., et al. 2003. Endocr. Res. 29: 343-351.

    分子式
    C18H24O3
    分子量
    288.38
    CAS号
    50-27-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    57 mg/mL
    Water
    <1 mg/mL
    Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00451204 Relapsing Remitting Multiple Sclerosis Drug: Estriol|Drug: Placebo|Drug: Copaxone University of California, Los Angeles|Washington University School of Medicine|University of Texas Southwestern Medical Center|Ohio State University|University of Medicine and Dentistry of New Jersey|University of Chicago|University of Utah|Johns Hopkins University|University of Kansas Medical Center|University of Minnesota, MN|Mayo Clinic|University of Colorado, Aurora|University of New Mexico|University of Pennsylvania|Dartmouth-Hitchcock Medical Center|National Multiple Sclerosis Society|National Institutes of Health (NIH)|National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2007-03-01 2016-05-10
    NCT02413008 Vaginal Atrophy Drug: estriol|Drug: Placebo ITF Research Pharma, S.L.U.|Spanish Breast Cancer Research Group Phase 2 2015-04-01 2017-02-24
    NCT02906111 Genital Prolapse Drug: estriol|Procedure: vaginal surgery Salvatore Caruso|Policlinico Universitario, Catania Phase 4 2016-11-01 2016-09-14
    NCT00908570 Vaginal Health Drug: estriol|Drug: Placebo Gynuity Health Projects|University of Illinois at Chicago|University of California, Los Angeles|Tulane University School of Medicine|Magee-Women's Research Institute|Oregon Health and Science University Phase 1 2009-06-01 2011-03-03
    NCT03044652 Vulvovaginal Atrophy Device: WO2085 Moisturising Cream|Drug: Estriol Cream 0.1% Dr. August Wolff GmbH & Co. KG Arzneimittel|proDERM Institut f眉r Angewandte Dermatologische Forschung GmbH|Bremer Pharmacovigilance Service GmbH|GCP-Service International Ltd. & Co. KG Phase 4 2016-11-01 2017-02-27
    NCT02967510 Vaginal Atrophy Drug: Estriol|Drug: Placebo ITF Research Pharma, S.L.U. Phase 2 2016-10-01 2017-02-24
    NCT00900653 Urinary Tract Infections Drug: Gynoflor E (low dose estriol with lactobacillus) Yonsei University Phase 4 2009-05-01 2009-05-29
    NCT01466114 Relapsing-remitting Multiple Sclerosis|Secondary-progressive Multiple Sclerosis|Primary-progressive Multiple Sclerosis Drug: estriol|Other: Placebo|Drug: Norethindrone|Other: Progestin Placebo University of California, Los Angeles|Synthetic Biologics (formerly Adeona Pharmaceuticals) Phase 2 2011-10-01 2016-02-03
    NCT02112513 Neonatal Respiratory Distress Syndrome Indiana University|University of California, Los Angeles Phase 4 2012-11-01 2016-09-02
    NCT01370551 Atrophic Vaginitis Drug: Gynoflor Medinova AG Phase 1 2011-04-01 2012-08-21
    NCT00156000 Preterm Delivery|Preterm Birth Device: Fetal Fibronectin|Device: Salivary Estriol Obstetrix Medical Group|Adeza Biomedical|Mednax Center for Research, Education and Quality Phase 1 2005-08-01 2014-12-17
    NCT01557179 The Primary Objective of This Study Was to Assess the Efficacy and Safety of Hyaluronic Acid Vaginal Gel in Treating Vaginal Dryness Device: Hyalofemme|Device: Estriol cream (Ovestin) Lee's Pharmaceutical Limited|Fidia Farmaceutici s.p.a. Phase 2 2009-05-01 2012-03-16
    NCT01319968 Vulvovaginal Atrophy|Dyspareunia Among Puerperal Women Drug: Estriol 0.1% vaginal cream Meir Medical Center 2011-03-01 2015-04-07
    NCT00816556 Atrophic Vaginitis Drug: Estriol|Drug: Estradiol valerate|Drug: Vanicream Lite Maire Mac Bride|National Center for Advancing Translational Science (NCATS)|Mayo Clinic Phase 3 2008-10-01 2014-02-12
    NCT02733731 Atrophic Vaginitis Drug: Chinese Herbal Compound Ointment|Drug: Estriol First Affiliated Hospital, Sun Yat-Sen University Phase 1 2016-02-01 2016-04-08
    NCT00864214 Menopause Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Vivelle-Dot) Mayo Clinic Phase 1 2008-06-01 2012-01-12
    NCT01408030 Telangiectasia, Hereditary Hemorrhagic|Epistaxis Drug: Sterile saline|Drug: Bevacizumab|Drug: Estriol|Drug: Tranexamic Acid James Gossage|Hereditary Hemorrhagic Telangiectasia Foundation International|Augusta University Phase 2 2011-08-01 2014-11-05
    NCT00302731 Menopause Drug: Prempro, premarin, provera conjugated estrogens, medroxyprogesterone acetate|Drug: Estradiol , estriol , progesterone|Drug: estradiol,progesterone|Drug: estriol, progesterone Jeanne Drisko, MD, CNS, FACN|Private Foundation through KU Endowment|University of Kansas|University of Kansas Medical Center Phase 2 2006-02-01 2014-01-06
    NCT00866437 Premenstrual Syndrome Drug: Skin test panel|Drug: Skin test panel EVE Medical Systems Ltd. Phase 2 2009-04-01 2010-06-15
    NCT00873262 Premenstrual Syndrome Drug: Skin test panel and desensitization kit|Drug: Skin test panel and solvent EVE Medical Systems Ltd. Phase 2 2009-04-01 2010-06-15
    NCT02419729 Vulvovaginal Atrophy Device: CO2 laser|Drug: Estrogen|Drug: Placebo of Estrogen|Device: Placebo of CO2 laser Faculdade de Medicina do ABC Phase 3 2015-03-01 2016-06-24
    NCT02033512 Menopause Drug: Transdermal Hormone Replacement Therapy|Drug: Transdermal Nanoformulation|Drug: Transdermal formulation University Potiguar|Universidade Federal de Sergipe Phase 2 2003-01-01 2014-01-09

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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