Estriol是G蛋白偶联雌激素受体拮抗剂,可作用于雌激素受体阴性乳腺癌细胞。
Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
100 nM
4 μg/g/day 皮下注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Lappano R, et al. Mol Cell Endocrinol. 2010, 320(1-2), 162-170.
[2] Dessole, S., et al. 2004. Menopause. 11: 49-56.
[3] Luo, X.H., et al. 2003. Endocr. Res. 29: 343-351.
分子式 C18H24O3 |
分子量 288.38 |
CAS号 50-27-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 57 mg/mL |
Water <1 mg/mL |
Ethanol 10 mg/mL |
体内溶解度
NCT00451204 | Relapsing Remitting Multiple Sclerosis | Drug: Estriol|Drug: Placebo|Drug: Copaxone | University of California, Los Angeles|Washington University School of Medicine|University of Texas Southwestern Medical Center|Ohio State University|University of Medicine and Dentistry of New Jersey|University of Chicago|University of Utah|Johns Hopkins University|University of Kansas Medical Center|University of Minnesota, MN|Mayo Clinic|University of Colorado, Aurora|University of New Mexico|University of Pennsylvania|Dartmouth-Hitchcock Medical Center|National Multiple Sclerosis Society|National Institutes of Health (NIH)|National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 | 2007-03-01 | 2016-05-10 |
NCT02413008 | Vaginal Atrophy | Drug: estriol|Drug: Placebo | ITF Research Pharma, S.L.U.|Spanish Breast Cancer Research Group | Phase 2 | 2015-04-01 | 2017-02-24 |
NCT02906111 | Genital Prolapse | Drug: estriol|Procedure: vaginal surgery | Salvatore Caruso|Policlinico Universitario, Catania | Phase 4 | 2016-11-01 | 2016-09-14 |
NCT00908570 | Vaginal Health | Drug: estriol|Drug: Placebo | Gynuity Health Projects|University of Illinois at Chicago|University of California, Los Angeles|Tulane University School of Medicine|Magee-Women's Research Institute|Oregon Health and Science University | Phase 1 | 2009-06-01 | 2011-03-03 |
NCT03044652 | Vulvovaginal Atrophy | Device: WO2085 Moisturising Cream|Drug: Estriol Cream 0.1% | Dr. August Wolff GmbH & Co. KG Arzneimittel|proDERM Institut f眉r Angewandte Dermatologische Forschung GmbH|Bremer Pharmacovigilance Service GmbH|GCP-Service International Ltd. & Co. KG | Phase 4 | 2016-11-01 | 2017-02-27 |
NCT02967510 | Vaginal Atrophy | Drug: Estriol|Drug: Placebo | ITF Research Pharma, S.L.U. | Phase 2 | 2016-10-01 | 2017-02-24 |
NCT00900653 | Urinary Tract Infections | Drug: Gynoflor E (low dose estriol with lactobacillus) | Yonsei University | Phase 4 | 2009-05-01 | 2009-05-29 |
NCT01466114 | Relapsing-remitting Multiple Sclerosis|Secondary-progressive Multiple Sclerosis|Primary-progressive Multiple Sclerosis | Drug: estriol|Other: Placebo|Drug: Norethindrone|Other: Progestin Placebo | University of California, Los Angeles|Synthetic Biologics (formerly Adeona Pharmaceuticals) | Phase 2 | 2011-10-01 | 2016-02-03 |
NCT02112513 | Neonatal Respiratory Distress Syndrome | Indiana University|University of California, Los Angeles | Phase 4 | 2012-11-01 | 2016-09-02 | |
NCT01370551 | Atrophic Vaginitis | Drug: Gynoflor | Medinova AG | Phase 1 | 2011-04-01 | 2012-08-21 |
NCT00156000 | Preterm Delivery|Preterm Birth | Device: Fetal Fibronectin|Device: Salivary Estriol | Obstetrix Medical Group|Adeza Biomedical|Mednax Center for Research, Education and Quality | Phase 1 | 2005-08-01 | 2014-12-17 |
NCT01557179 | The Primary Objective of This Study Was to Assess the Efficacy and Safety of Hyaluronic Acid Vaginal Gel in Treating Vaginal Dryness | Device: Hyalofemme|Device: Estriol cream (Ovestin) | Lee's Pharmaceutical Limited|Fidia Farmaceutici s.p.a. | Phase 2 | 2009-05-01 | 2012-03-16 |
NCT01319968 | Vulvovaginal Atrophy|Dyspareunia Among Puerperal Women | Drug: Estriol 0.1% vaginal cream | Meir Medical Center | 2011-03-01 | 2015-04-07 | |
NCT00816556 | Atrophic Vaginitis | Drug: Estriol|Drug: Estradiol valerate|Drug: Vanicream Lite | Maire Mac Bride|National Center for Advancing Translational Science (NCATS)|Mayo Clinic | Phase 3 | 2008-10-01 | 2014-02-12 |
NCT02733731 | Atrophic Vaginitis | Drug: Chinese Herbal Compound Ointment|Drug: Estriol | First Affiliated Hospital, Sun Yat-Sen University | Phase 1 | 2016-02-01 | 2016-04-08 |
NCT00864214 | Menopause | Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Vivelle-Dot) | Mayo Clinic | Phase 1 | 2008-06-01 | 2012-01-12 |
NCT01408030 | Telangiectasia, Hereditary Hemorrhagic|Epistaxis | Drug: Sterile saline|Drug: Bevacizumab|Drug: Estriol|Drug: Tranexamic Acid | James Gossage|Hereditary Hemorrhagic Telangiectasia Foundation International|Augusta University | Phase 2 | 2011-08-01 | 2014-11-05 |
NCT00302731 | Menopause | Drug: Prempro, premarin, provera conjugated estrogens, medroxyprogesterone acetate|Drug: Estradiol , estriol , progesterone|Drug: estradiol,progesterone|Drug: estriol, progesterone | Jeanne Drisko, MD, CNS, FACN|Private Foundation through KU Endowment|University of Kansas|University of Kansas Medical Center | Phase 2 | 2006-02-01 | 2014-01-06 |
NCT00866437 | Premenstrual Syndrome | Drug: Skin test panel|Drug: Skin test panel | EVE Medical Systems Ltd. | Phase 2 | 2009-04-01 | 2010-06-15 |
NCT00873262 | Premenstrual Syndrome | Drug: Skin test panel and desensitization kit|Drug: Skin test panel and solvent | EVE Medical Systems Ltd. | Phase 2 | 2009-04-01 | 2010-06-15 |
NCT02419729 | Vulvovaginal Atrophy | Device: CO2 laser|Drug: Estrogen|Drug: Placebo of Estrogen|Device: Placebo of CO2 laser | Faculdade de Medicina do ABC | Phase 3 | 2015-03-01 | 2016-06-24 |
NCT02033512 | Menopause | Drug: Transdermal Hormone Replacement Therapy|Drug: Transdermal Nanoformulation|Drug: Transdermal formulation | University Potiguar|Universidade Federal de Sergipe | Phase 2 | 2003-01-01 | 2014-01-09 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们