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Cyproterone Acetate

醋酸环丙氯地孕酮

Cyproterone acetate 是高活性雄激素受体(AR)拮抗剂,IC50为7.1 nM,还是弱的孕酮受体激动剂。

目录号
EY0540
EY0540
纯度
99.47%
99.47%
规格
200 mg
500 mg
原价
520
1100
售价
520
1100
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0-10 μM

  • 动物实验

    0.2 mg /kg/day皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Sonneveld E, et al. Toxicol Sci. 2005, 83(1), 136-148.
    [2] Kasper, P., Mueller, L. Carcinogenesis. 20:2185-8 (1999).

    分子式
    C23H27ClO4
    分子量
    402.91
    CAS号
    427-51-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    ≥83 mg/mL
    Water
    <1 mg/mL
    Ethanol
    ≥10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00782847 Diabetic Nephropathy Behavioral: DiaNe consultation and support program DiaNe HCM GmbH|Roche Pharma Deutschland GmbH, Grenzach-Wyhlen, Germany|Institute for Medical Outcom Research GmbH, Loerrach, Germany Phase 3 2004-07-01 2008-10-30
    NCT02494297 Hirsutism|Seborrheic Alopecia|Severe Acne|Seborrhea Center for Epidemiology and Health Research, Germany|Bayer 2015-03-01 2016-11-02
    NCT00919022 Prostate Cancer Drug: Cyproterone Acetate (Androcur, BAY94-8367) Bayer 2009-08-01 2012-10-30
    NCT02349399 Acne Vulgaris Drug: Cyproterone / Ethinylestradiol (Diane-35, BAY86-5264) and its Generics Bayer 2015-05-01 2016-03-08
    NCT00005623 Hot Flashes|Prostate Cancer Drug: cyproterone acetate|Procedure: quality-of-life assessment Barr Laboratories|National Cancer Institute (NCI) Phase 3 1999-12-01 2013-03-25
    NCT00908674 Prostate Cancer Drug: Cyproterone acetate (Androcur) Bayer 2008-06-01 2010-04-12
    NCT01752270 Polycystic Ovary Syndrome Drug: Diane-35 pretreatment|Drug: Diane-35 pretreatment First Affiliated Hospital, Sun Yat-Sen University Phase 4 2012-12-01 2012-12-16
    NCT01573377 Polycystic Ovary Syndrome|Insulin Resistance Drug: Metformin|Drug: Ethinylestradiol and Cyproterone Acetate Chongqing Medical University 2012-02-01 2013-12-26
    NCT00752635 Acne Vulgaris Drug: Norgestimate-ethinyl estradiol; Cyproterone acetate-ethinyl estradiol Johnson & Johnson Taiwan Ltd Phase 4 2004-09-01 2011-05-18
    NCT02689843 Polycystic Ovary Syndrome Drug: Cyproterone compound + Spironolactone|Drug: Metformin|Drug: Pioglitazone Shiraz University of Medical Sciences Early Phase 1 2016-03-01 2016-08-02
    NCT00849082 Prostate Cancer Drug: cyproterone acetate|Drug: goserelin acetate|Radiation: radiation therapy European Organisation for Research and Treatment of Cancer - EORTC Phase 3 1987-05-01 2012-07-10
    NCT00363285 Prostate Cancer Biological: gonadotrophin releasing hormone|Drug: cyproterone acetate|Procedure: quality-of-life assessment St. Bartholomew's Hospital|National Cancer Institute (NCI) Phase 3 2003-01-01 2013-08-23
    NCT01011751 Adenocarcinoma, Prostate Drug: Cyproterone acetate|Drug: Medroxyprogesterone acetate|Drug: Venlafaxine|Drug: Leuprorelin|Drug: Flutamide|Drug: Placebo Takeda Phase 3 2004-04-01 2015-07-29
    NCT00955058 Polycystic Ovary Syndrome Drug: OCP Shahid Beheshti University Phase 2|Phase 3 2007-02-01 2009-09-01
    NCT03043924 Polycystic Ovary Syndrome Drug: Cyproterone Acetate + estradiol|Drug: Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet University Hospital, Lille|National Research Agency, France 2017-03-01 2017-02-02
    NCT02866786 Polycystic Ovary Syndrome Drug: Metformin|Drug: ethinyl estradiol and cyproterone acetate S.C.B. Medical College and Hospital Phase 4 2016-08-01 2016-08-31
    NCT02729545 Polycystic Ovarian Syndrome Other: acupuncture|Drug: Diane-35 Beijing Hospital of Integrated Traditional Chinese and Western Medicine Phase 2 2016-01-01 2016-03-31
    NCT02744131 Polycystic Ovary Syndrome Drug: Oral contraceptive pill combination of ethyl estradiol and Cyproterone acetate|Drug: Metformin 1500mgs per day Kar Clinic & Hospital Pvt. Ltd.|All India Institute of Medical Sciences, New Delhi|Nova IVI Fertility, New Delhi|Dr Patil's Fertility & Endoscopy Clinic, Bangalore|Shreyas Hospital & Sushrut Assisted Conception Clinic, Kolhapur 2016-05-01 2016-08-30
    NCT01973816 Endometriosis Drug: Triptoreline 11.25 i.v.; Estradiol 0.5% percutaneous gel;|Procedure: rectal shaving; rectal disc excision; colorectal resection|Drug: Cyproterone acetate 50 mg; estradiol 0.5% percutaneous|Drug: Estradiol 0.5% percutaneous gel; Cyproterone acetate 50 mg oral University Hospital, Rouen Phase 3 2014-11-01 2016-08-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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