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Adefovir Dipivoxil

阿德福韦酯,Hepsera,GS 0840,Preveon,GS-0840,GS0840,

Adefovir Dipivoxil可阻断HBV逆转录酶。

目录号
EY0534
EY0534
EY0534
纯度
99.29%
99.29%
99.29%
规格
2 mg
5 mg
10 mg
原价
450
1200
1900
售价
450
1200
1900
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Julander JG, et al. Antiviral Res, 2002, 55(1), 27-40.
    [2] Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38.
    [3] Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.
    [4] Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16.

    分子式
    C20H32N5O8P    		 分子量
    501.47    		 CAS号
    142340-99-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    100 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01329419 Hepatitis B Drug: adefovir dipivoxil GlaxoSmithKline 2004-08-01 2011-03-10
    NCT00441974 Chronic Hepatitis B Drug: adefovir dipivoxil GlaxoSmithKline Phase 4 2006-12-01 2009-10-15
    NCT00324961 Chronic Hepatitis B Drug: adefovir dipivoxil tablets GlaxoSmithKline Phase 4 2006-01-01 2009-10-26
    NCT00187746 Other Conditions That May Be A Focus of Clinical Attention Drug: Adefovir dipivoxil University of California, San Francisco Phase 4 2005-08-01 2012-11-20
    NCT01353742 Hepatitis B, Chronic Drug: Lamivudine|Drug: Adefovir dipivoxil|Drug: Fixed dose combination (Lamivudine and Adefovir dipivoxil) GlaxoSmithKline Phase 1 2011-02-01 2016-10-27
    NCT01436539 Chronic Hepatitis B Drug: Adefovir Dipivoxil and polyene phosphatidylcholine|Drug: Adefovir Dipivoxil Jun Cheng|Sanofi|Fujian Cosunter Pharmaceutical Co. Ltd|Capital Medical University Phase 4 2011-09-01 2011-09-16
    NCT02327689 Hepatitis B, Chronic|Fibrosis Drug: Emtricitabine plus adefovir dipivoxil Asian-Pacific Alliance of Liver Disease, Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission, P.R.China Phase 4 2015-01-01 2014-12-29
    NCT00347009 Hepatitis B, Chronic|Cirrhosis|Fibrosis|Chronic Hepatitis B Drug: adefovir dipivoxil GlaxoSmithKline Phase 4 2005-05-01 2012-05-31
    NCT00403585 Hepatitis B, Chronic|Chronic Hepatitis B Drug: adefovir dipivoxil 10mg GlaxoSmithKline Phase 4 2006-07-01 2010-11-24
    NCT00644761 Hepatitis B Drug: Adefovir Dipivoxil Gilead Sciences Phase 2 2004-02-01 2008-04-07
    NCT00489151 Hepatitis B Drug: adefovir dipivoxil|Drug: lamivudine Hospital Authority, Hong Kong|The University of Hong Kong 2005-06-01 2010-07-06
    NCT01146808 Hepatitis B|Liver Transplantation Drug: Adefovir dipivoxil and hepatitis B vaccination Columbia University|Gilead Sciences Phase 1|Phase 2 2006-03-01 2017-01-25
    NCT00645294 Hepatitis B Drug: Adefovir dipivoxil|Drug: Adefovir Dipivoxil|Drug: Adefovir Dipivoxil Gilead Sciences Phase 1|Phase 2 2003-02-01 2008-03-21
    NCT01205165 Hepatitis B, Chronic Drug: Adefor dipivoxil GlaxoSmithKline Phase 4 2004-12-01 2011-01-22
    NCT01546116 Chronic Hepatitis B Drug: ADEFOVIR, LAMIVUDINE Korea University|GlaxoSmithKline Phase 4 2010-02-01 2014-02-14
    NCT00316719 Chronic Hepatitis B Drug: LAM group|Drug: ADV group GlaxoSmithKline Phase 3 2006-01-01 2009-10-01
    NCT00641082 HBeAg(-) Chronic Hepatitis B With Compensated Liver Function Drug: Clevudine|Drug: Adefovir dipivoxil Bukwang Pharmaceutical Phase 4 2008-02-01 2012-04-24
    NCT00158704 Hepatitis B Drug: Hepsera Gilead Sciences 2002-01-01 2007-03-07
    NCT00531167 Chronic Hepatitis B Drug: combination of lamivudine+adefovir vs entecavir Korea University|GlaxoSmithKline Phase 4 2007-04-01 2012-10-18
    NCT00230477 Hepatitis B Drug: Hepsera|Drug: Hepsera and lamivudine University of Washington|Gilead Sciences|GlaxoSmithKline Phase 4 2003-04-01 2007-11-14
    NCT00307242 Chronic Hepatitis B Drug: Adefovir Dipivoxil Thomas Jefferson University Phase 4 2005-05-01 2014-12-08
    NCT00371761 Hepatitis B, Chronic (CHB) Biological: Pegylated interferon alfa-2b (PegIntron)|Drug: Adefovir dipivoxil (adefovir) Merck Sharp & Dohme Corp. Phase 3 2006-09-01 2015-10-07

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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