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Dexamethasone Acetate

醋酸地塞美松,醋酸氟美松,NNSC39471,NSC-39471,NSC 39471

Dexamethasone是糖皮质素类甾体化合物，有抗炎和免疫抑制活性。

目录号
EY0528
EY0528
纯度
99.13%
99.13%
规格
100 mg
500 mg
原价
250
470
售价
250
470
库存
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Blanco FJ, et al. J Rheumatol, 1999, 26(6), 1366-1373.
    [2] Inamura, H., et al. 2001. Allergy. 56: 672-678.
    [3] Clark, J.A., et al. 2008. Mol. Psychiatry. 13: 498-506.
    [4] Wang, M.T., et al. 2010. Int J. Nanomedicine. 5: 487-497.

    分子式
    C24H31FO6    		 分子量
    434.5    		 CAS号
    1177-87-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    86 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01410201 Epiretinal Membrane|Macular Edema Drug: Dexamethasone Intravitreal Implant Barnes Retina Institute|Allergan 2011-08-01 2016-07-26
    NCT01946399 Retinal Vein Occlusion (RVO)|Macular Edema Drug: Ozurdex implant Retina Research Institute, LLC|Retina-Vitreous Associates Medical Group|West Coast Retina Medical Group, Inc. 2013-09-01 2015-12-21
    NCT02402725 Multiple Myeloma Drug: Dexamethasone Boston Medical Center Phase 2 2015-05-01 2017-02-14
    NCT00011362 Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Bronchopulmonary Dysplasia Drug: Dexamethasone Early|Drug: Dexamethasone Late NICHD Neonatal Research Network|National Center for Research Resources (NCRR) Phase 3 1992-09-01 2015-06-03
    NCT01892163 Diabetic Macular Edema Device: Ozurdex Moorfields Eye Hospital NHS Foundation Trust|The Royal Wolverhampton Hospitals NHS Trust|Frimley Park Hospital NHS Trust|Brighton and Sussex University Hospitals NHS Trust|University Hospitals Bristol NHS Foundation Trust Phase 3 2013-03-01 2017-01-03
    NCT02850601 Lichen Planus Drug: Dexamethasone Brigham and Women's Hospital Phase 2 2016-11-01 2016-07-29
    NCT02995746 Macular Edema|Epiretinal Membrane|Vitrectomy Drug: Dexamethasone Wills Eye|Mid Atlantic Retina 2015-02-01 2016-12-13
    NCT02864602 Anesthesia, Conduction Drug: IV dexamethasone University Health Network, Toronto Phase 3 2016-07-01 2016-08-11
    NCT01772381 Transient Tachypnea of the Newborn Drug: Dexamethasone Ain Shams Maternity Hospital 2010-03-01 2013-01-18
    NCT01701518 Epiretinal Membrane|Macular Edema Drug: Ozurdex Sunnybrook Health Sciences Centre|St. Michael's Hospital, Toronto|Allergan 2012-10-01 2016-01-04
    NCT01698788 Diabetic Macular Edema|Vision Disorders Drug: Dexamethasone Drug delivery system (Ozurdex) Postgraduate Institute of Medical Education and Research 2011-05-01 2012-09-29
    NCT01284478 Pseudophakic Cystoid Macular Edema,|Diabetic Macular Edema Drug: Dexamethasone Implant Northern California Retina Vitreous Associates|Allergan Phase 2 2011-01-01 2012-10-03
    NCT01698749 Diabetic Macular Edema|Macular Edema, Cystoid|Vision Disorders|Clinically Significant Macular Edema Drug: long acting intravitreal dexamethasone implant Postgraduate Institute of Medical Education and Research 2011-12-01 2012-09-29
    NCT03043495 Dexamethasone|Supraclavicular Brachial Plexus Block Procedure: Ultrasound guided supraclavicular brachial plexus block|Drug: Dexamethasone Eslam Ayman Mohamed Shawki|Cairo University Phase 4 2016-10-01 2017-02-03
    NCT01372904 Cisplatin Ototoxicity Drug: Dexamethasone Phosphate Meir Medical Center Phase 4 2011-06-01 2014-07-16
    NCT03003416 Diabetic Macular Edema Drug: dexamethasone intravitreal implant Allergan 2017-03-01 2017-01-20
    NCT01861340 Myeloma Drug: Lenalidomide, Dexamethasone, and MEDI-551 Sidney Kimmel Comprehensive Cancer Center|MedImmune LLC Early Phase 1 2014-05-01 2016-10-12
    NCT02271698 Acute Pain|Chronic Pain Drug: Dexamethasone|Other: Placebo Duke University Phase 4 2014-12-01 2017-01-12
    NCT02951975 Non-infectious Uveitis Drug: dexamethasone intravitreal implant Allergan 2017-01-01 2017-02-02
    NCT02153060 Immune Thrombocytopenia Drug: Dexamethasone|Drug: Dexamethasone Shandong University|Chinese Academy of Medical Sciences|Shandong Provincial Hospital|The First Affiliated Hospital of Dalian Medical University|Peking Union Medical College Hospital|Shandong University of Traditional Chinese Medicine|Anhui Provincial Hospital|Second Hospital of Shanxi Medical University Phase 2 2014-05-01 2016-04-18
    NCT00438828 Cancer Drug: dexamethasone Sunnybrook Health Sciences Centre Phase 1 2007-02-01 2014-11-17
    NCT02815319 Cancer Drug: Dexamethasone Ottawa Hospital Research Institute Phase 4 2017-01-01 2017-02-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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