Riluzole (利鲁唑) 是谷氨酸盐拮抗剂。
Riluzole is a drug used to treat amyotrophic lateral sclerosis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Doble A. Neurology, 1996, 47(6 Suppl 4), S233-241.
[2] Song, J.H., et al. 1997. J. Pharmacol. Exp. Ther. 282: 707-714.
[3] Mathie, A. and Veale, E.L. 2007. Curr Opin Investig Drugs. 8: 555-562.
[4] Chandu, B.R., et al. 2010. Anal Bioanal Chem.
[5] Takahashi, K., et al. 2010. Behav Brain Res.
分子式 C8H5F3N2OS |
分子量 234.2 |
CAS号 1744-22-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >25 mg/m |
Water Insoluble |
Ethanol >25 mg/mL |
体内溶解度
NCT02796755 | Inflammation|Fatigue | Drug: Riluzole|Drug: Placebo | Emory University | Phase 4 | 2016-04-01 | 2016-12-08 |
NCT00895752 | Fragile X Syndrome | Drug: Riluzole | Indiana University|Indiana Clinical and Translational Sciences Institute | Phase 4 | 2009-04-01 | 2013-04-16 |
NCT02155829 | PTSD | Drug: Riluzole|Drug: Placebo (for Riluzole) | Uniformed Services University of the Health Sciences|U.S. Army Medical Research and Materiel Command | Phase 1|Phase 2 | 2013-07-01 | 2014-07-21 |
NCT01204918 | Depression | Drug: Riluzole|Drug: placebo | Yale University | Phase 2 | 2011-06-01 | 2015-02-02 |
NCT02081027 | Autism Spectrum Disorders | Drug: Riluzole|Drug: placebo | Children's Hospital Medical Center, Cincinnati | Phase 2|Phase 3 | 2013-06-01 | 2016-08-31 |
NCT01018836 | Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific | Drug: riluzole|Radiation: whole-brain radiation therapy | Rutgers, The State University of New Jersey|National Cancer Institute (NCI) | Phase 1 | 2009-11-01 | 2014-04-30 |
NCT01303341 | Adult Solid Neoplasm|Recurrent Melanoma|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma | Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Drug: Riluzole|Drug: Sorafenib Tosylate | National Cancer Institute (NCI) | Phase 1 | 2011-02-01 | 2017-02-06 |
NCT00523718 | Obsessive-compulsive Disorder|Ocd | Drug: riluzole|Drug: placebo | Yale University | Phase 2 | 2006-09-01 | 2016-05-25 |
NCT00251303 | Obsessive-Compulsive Disorder|Autism Spectrum Disorder|Autism|Asperger Disorder|Developmental Disorder | Drug: Riluzole|Drug: Placebo | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2005-08-01 | 2014-07-14 |
NCT01257828 | Cervical Spondylotic Myelopathy | Drug: riluzole|Drug: Placebo medication | AOSpine North America Research Network | Phase 3 | 2011-12-01 | 2016-07-06 |
NCT02019940 | PTSD | Drug: Riluzole | Yale University|National Center for PTSD | Phase 1 | 2014-01-01 | 2017-02-04 |
NCT00544544 | Bipolar Depression | Drug: Riluzole | Mclean Hospital | 2007-06-01 | 2012-03-09 | |
NCT01661855 | Autism Spectrum Disorders | Drug: Riluzole|Drug: Placebo | Evdokia Anagnostou|Holland Bloorview Kids Rehabilitation Hospital|McMaster University|The Hospital for Sick Children|University of Western Ontario, Canada|St. Michael's Hospital, Toronto|University of Toronto|Anagnostou, Evdokia, M.D. | Phase 2 | 2013-09-01 | 2017-03-17 |
NCT01104649 | Cerebellar Ataxia | Drug: riluzole|Drug: Placebo comparator | S. Andrea Hospital|Agenzia Italiana del Farmaco | Phase 2|Phase 3 | 2010-04-01 | 2015-04-20 |
NCT00866840 | Melanoma (Skin) | Drug: riluzole | Rutgers, The State University of New Jersey|National Cancer Institute (NCI) | Phase 2 | 2009-04-01 | 2013-11-18 |
NCT00876889 | Spinal Cord Injury | Drug: Riluzole | The Methodist Hospital System|Christopher Reeve Paralysis Foundation|United States Department of Defense|AO Clinical Investigation and Documentation|Ontario Neurotrauma Foundation | 2010-04-01 | 2013-07-29 | |
NCT01703039 | Major Depressive Disorder | Drug: Riluzole|Drug: Sertraline|Other: placebo | Brigham and Women's Hospital | Phase 2 | 2013-01-01 | 2016-05-11 |
NCT00054704 | Bipolar Disorder | Drug: Riluzole|Drug: Placebo | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2003-02-01 | 2016-05-17 |
NCT03017508 | Social Anxiety Disorder|Performance Anxiety | Drug: BHV-0223|Drug: Placebo | Yale University|Biohaven Pharmaceuticals Inc. | Phase 2|Phase 3 | 2017-01-01 | 2017-01-12 |
NCT00375050 | Schizophrenia|Schizoaffective | Drug: Riluzole|Drug: Placebo | Yale University|Stanley Medical Research Institute | 2002-05-01 | 2015-11-16 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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