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Riluzole

利鲁唑,RP-54274,PK 26124,PK-26124,PK26124,RP 54274,RP54274,

Riluzole (利鲁唑) 是谷氨酸盐拮抗剂。

目录号
EY0523
EY0523
EY0523
纯度
99.58%
99.58%
99.58%
规格
50 mg
100 mg
500 MG
原价
400
780
2200
售价
400
780
2200
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Riluzole is a drug used to treat amyotrophic lateral sclerosis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Doble A. Neurology, 1996, 47(6 Suppl 4), S233-241.
    [2] Song, J.H., et al. 1997. J. Pharmacol. Exp. Ther. 282: 707-714.
    [3] Mathie, A. and Veale, E.L. 2007. Curr Opin Investig Drugs. 8: 555-562.
    [4] Chandu, B.R., et al. 2010. Anal Bioanal Chem.
    [5] Takahashi, K., et al. 2010. Behav Brain Res.

    分子式
    C8H5F3N2OS
    分子量
    234.2
    CAS号
    1744-22-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >25 mg/m
    Water
    Insoluble
    Ethanol
    >25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02796755 Inflammation|Fatigue Drug: Riluzole|Drug: Placebo Emory University Phase 4 2016-04-01 2016-12-08
    NCT00895752 Fragile X Syndrome Drug: Riluzole Indiana University|Indiana Clinical and Translational Sciences Institute Phase 4 2009-04-01 2013-04-16
    NCT02155829 PTSD Drug: Riluzole|Drug: Placebo (for Riluzole) Uniformed Services University of the Health Sciences|U.S. Army Medical Research and Materiel Command Phase 1|Phase 2 2013-07-01 2014-07-21
    NCT01204918 Depression Drug: Riluzole|Drug: placebo Yale University Phase 2 2011-06-01 2015-02-02
    NCT02081027 Autism Spectrum Disorders Drug: Riluzole|Drug: placebo Children's Hospital Medical Center, Cincinnati Phase 2|Phase 3 2013-06-01 2016-08-31
    NCT01018836 Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific Drug: riluzole|Radiation: whole-brain radiation therapy Rutgers, The State University of New Jersey|National Cancer Institute (NCI) Phase 1 2009-11-01 2014-04-30
    NCT01303341 Adult Solid Neoplasm|Recurrent Melanoma|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Drug: Riluzole|Drug: Sorafenib Tosylate National Cancer Institute (NCI) Phase 1 2011-02-01 2017-02-06
    NCT00523718 Obsessive-compulsive Disorder|Ocd Drug: riluzole|Drug: placebo Yale University Phase 2 2006-09-01 2016-05-25
    NCT00251303 Obsessive-Compulsive Disorder|Autism Spectrum Disorder|Autism|Asperger Disorder|Developmental Disorder Drug: Riluzole|Drug: Placebo National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Phase 2 2005-08-01 2014-07-14
    NCT01257828 Cervical Spondylotic Myelopathy Drug: riluzole|Drug: Placebo medication AOSpine North America Research Network Phase 3 2011-12-01 2016-07-06
    NCT02019940 PTSD Drug: Riluzole Yale University|National Center for PTSD Phase 1 2014-01-01 2017-02-04
    NCT00544544 Bipolar Depression Drug: Riluzole Mclean Hospital 2007-06-01 2012-03-09
    NCT01661855 Autism Spectrum Disorders Drug: Riluzole|Drug: Placebo Evdokia Anagnostou|Holland Bloorview Kids Rehabilitation Hospital|McMaster University|The Hospital for Sick Children|University of Western Ontario, Canada|St. Michael's Hospital, Toronto|University of Toronto|Anagnostou, Evdokia, M.D. Phase 2 2013-09-01 2017-03-17
    NCT01104649 Cerebellar Ataxia Drug: riluzole|Drug: Placebo comparator S. Andrea Hospital|Agenzia Italiana del Farmaco Phase 2|Phase 3 2010-04-01 2015-04-20
    NCT00866840 Melanoma (Skin) Drug: riluzole Rutgers, The State University of New Jersey|National Cancer Institute (NCI) Phase 2 2009-04-01 2013-11-18
    NCT00876889 Spinal Cord Injury Drug: Riluzole The Methodist Hospital System|Christopher Reeve Paralysis Foundation|United States Department of Defense|AO Clinical Investigation and Documentation|Ontario Neurotrauma Foundation 2010-04-01 2013-07-29
    NCT01703039 Major Depressive Disorder Drug: Riluzole|Drug: Sertraline|Other: placebo Brigham and Women's Hospital Phase 2 2013-01-01 2016-05-11
    NCT00054704 Bipolar Disorder Drug: Riluzole|Drug: Placebo National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Phase 2 2003-02-01 2016-05-17
    NCT03017508 Social Anxiety Disorder|Performance Anxiety Drug: BHV-0223|Drug: Placebo Yale University|Biohaven Pharmaceuticals Inc. Phase 2|Phase 3 2017-01-01 2017-01-12
    NCT00375050 Schizophrenia|Schizoaffective Drug: Riluzole|Drug: Placebo Yale University|Stanley Medical Research Institute 2002-05-01 2015-11-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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