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Idebenone

艾地苯醌,CV-2619,CV 2619,CV2619

Idebenone (艾地苯醌) 是合成的辅酶Q10的变体,最初用于阿尔茨海默症和其它的认知缺陷。

目录号
EY0516
EY0516
EY0516
EY0516
纯度
99.59%
99.59%
99.59%
99.59%
规格
1 mg
5 mg
10 mg
50 mg
原价
115
230
380
970
售价
115
230
380
970
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Rego AC, et al. Free Radic Biol Med, 1999, 26(11-12), 1405-1417.
    [2] Civenni, G., et al. 1999. Eur. J. Pharmacol. 370: 161-167.
    [3] Takuma, K., et al. 2000. Eur. J. Pharmacol. 406: 333-339.

    分子式
    C19H30O5
    分子量
    338.44
    CAS号
    58186-27-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >25 mg/mL
    Water
    Insoluble
    Ethanol
    >25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01303406 Friedreich's Ataxia Drug: Idebenone|Drug: Placebo Santhera Pharmaceuticals Phase 3 2011-04-01 2016-02-10
    NCT00229632 Friedreich Ataxia Drug: Idebenone National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 2 2005-09-23 2017-01-24
    NCT00697073 Friedreich's Ataxia Drug: Idebenone Santhera Pharmaceuticals Phase 3 2008-07-01 2013-05-24
    NCT00758225 Duchenne Muscular Dystrophy Drug: Idebenone Santhera Pharmaceuticals Phase 2 2008-09-01 2011-05-30
    NCT01027884 Muscular Dystrophy, Duchenne|Ambulatory Care Drug: Placebo|Drug: Idebenone Santhera Pharmaceuticals Phase 3 2009-07-01 2015-09-23
    NCT00950248 Primary Progressive Multiple Sclerosis Drug: Idebenone National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 1|Phase 2 2009-07-20 2017-01-24
    NCT00905268 Friedreich's Ataxia Drug: idebenone|Drug: Placebo Santhera Pharmaceuticals Phase 3 2006-04-01 2016-05-19
    NCT00747487 Leber's Hereditary Optic Neuropathy Drug: Idebenone|Drug: Placebo Santhera Pharmaceuticals Phase 2 2007-11-01 2013-05-24
    NCT00537680 Friedreich's Ataxia Drug: Idebenone|Drug: Idebenone|Drug: Placebo Santhera Pharmaceuticals Phase 3 2007-12-01 2012-02-02
    NCT00993967 Freidreich's Ataxia Drug: idebenone Santhera Pharmaceuticals Phase 3 2007-06-01 2012-08-28
    NCT00887562 MELAS Syndrome Drug: Idebenone|Drug: Idebenone|Other: Placebo Michio Hirano|Santhera Pharmaceuticals|Columbia University Phase 2 2009-05-01 2016-09-20
    NCT02814019 Duchenne Muscular Dystrophy (DMD) Drug: Idebenone 150 mg film-coated tablets|Drug: placebo Santhera Pharmaceuticals Phase 3 2016-09-01 2017-03-17
    NCT01854359 Multiple Sclerosis|Primary Progressive Multiple Sclerosis Drug: Idebenone National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 1|Phase 2 2013-02-22 2017-01-24
    NCT00654784 Duchenne Muscular Dystrophy (DMD) Drug: idebenone|Drug: placebo Santhera Pharmaceuticals Phase 2 2005-10-01 2011-07-29
    NCT00078481 Friedreich Ataxia Drug: Idebenone National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 1 2004-02-01 2008-03-03
    NCT00015808 Friedreich Ataxia Drug: Idebenone National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 1 2001-05-01 2006-07-11
    NCT01495715 Leber's Hereditary Optic Neuropathy Drug: Idebenone|Drug: Placebo Santhera Pharmaceuticals Phase 3 null 2014-08-21
    NCT02887443 Drug-Drug Interaction Drug: Raxone (idebenone 150 mg)|Drug: Midazolam 2,5 mg Santhera Pharmaceuticals Phase 1 2016-09-01 2016-11-23
    NCT02774005 Leber's Hereditary Optic Neuropathy (LHON) Drug: Idebenone Santhera Pharmaceuticals Phase 4 2016-05-01 2017-03-01
    NCT02771379 Leber's Hereditary Optic Neuropathy (LHON) Drug: Idebenone Santhera Pharmaceuticals 2016-09-01 2017-03-01
    NCT01421381 Leber's Hereditary Optic Neuropathy Santhera Pharmaceuticals 2011-09-01 2013-05-24
    NCT00224640 Friedreich Ataxia Drug: Iron chelating intervention Assistance Publique - H么pitaux de Paris Phase 1|Phase 2 2005-03-01 2009-03-03
    NCT03014908 Type1diabetes Other: Blood sampling Hasselt University|Jessa Hospital 2014-01-01 2017-01-06
    NCT03014856 Obesity, Pediatric Other: Blood sampling Hasselt University|Jessa Hospital 2012-05-01 2017-01-05

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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