Idebenone (艾地苯醌) 是合成的辅酶Q10的变体,最初用于阿尔茨海默症和其它的认知缺陷。
Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Rego AC, et al. Free Radic Biol Med, 1999, 26(11-12), 1405-1417.
[2] Civenni, G., et al. 1999. Eur. J. Pharmacol. 370: 161-167.
[3] Takuma, K., et al. 2000. Eur. J. Pharmacol. 406: 333-339.
分子式 C19H30O5 |
分子量 338.44 |
CAS号 58186-27-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >25 mg/mL |
Water Insoluble |
Ethanol >25 mg/mL |
体内溶解度
NCT01303406 | Friedreich's Ataxia | Drug: Idebenone|Drug: Placebo | Santhera Pharmaceuticals | Phase 3 | 2011-04-01 | 2016-02-10 |
NCT00229632 | Friedreich Ataxia | Drug: Idebenone | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2005-09-23 | 2017-01-24 |
NCT00697073 | Friedreich's Ataxia | Drug: Idebenone | Santhera Pharmaceuticals | Phase 3 | 2008-07-01 | 2013-05-24 |
NCT00758225 | Duchenne Muscular Dystrophy | Drug: Idebenone | Santhera Pharmaceuticals | Phase 2 | 2008-09-01 | 2011-05-30 |
NCT01027884 | Muscular Dystrophy, Duchenne|Ambulatory Care | Drug: Placebo|Drug: Idebenone | Santhera Pharmaceuticals | Phase 3 | 2009-07-01 | 2015-09-23 |
NCT00950248 | Primary Progressive Multiple Sclerosis | Drug: Idebenone | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | Phase 1|Phase 2 | 2009-07-20 | 2017-01-24 |
NCT00905268 | Friedreich's Ataxia | Drug: idebenone|Drug: Placebo | Santhera Pharmaceuticals | Phase 3 | 2006-04-01 | 2016-05-19 |
NCT00747487 | Leber's Hereditary Optic Neuropathy | Drug: Idebenone|Drug: Placebo | Santhera Pharmaceuticals | Phase 2 | 2007-11-01 | 2013-05-24 |
NCT00537680 | Friedreich's Ataxia | Drug: Idebenone|Drug: Idebenone|Drug: Placebo | Santhera Pharmaceuticals | Phase 3 | 2007-12-01 | 2012-02-02 |
NCT00993967 | Freidreich's Ataxia | Drug: idebenone | Santhera Pharmaceuticals | Phase 3 | 2007-06-01 | 2012-08-28 |
NCT00887562 | MELAS Syndrome | Drug: Idebenone|Drug: Idebenone|Other: Placebo | Michio Hirano|Santhera Pharmaceuticals|Columbia University | Phase 2 | 2009-05-01 | 2016-09-20 |
NCT02814019 | Duchenne Muscular Dystrophy (DMD) | Drug: Idebenone 150 mg film-coated tablets|Drug: placebo | Santhera Pharmaceuticals | Phase 3 | 2016-09-01 | 2017-03-17 |
NCT01854359 | Multiple Sclerosis|Primary Progressive Multiple Sclerosis | Drug: Idebenone | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | Phase 1|Phase 2 | 2013-02-22 | 2017-01-24 |
NCT00654784 | Duchenne Muscular Dystrophy (DMD) | Drug: idebenone|Drug: placebo | Santhera Pharmaceuticals | Phase 2 | 2005-10-01 | 2011-07-29 |
NCT00078481 | Friedreich Ataxia | Drug: Idebenone | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2004-02-01 | 2008-03-03 |
NCT00015808 | Friedreich Ataxia | Drug: Idebenone | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2001-05-01 | 2006-07-11 |
NCT01495715 | Leber's Hereditary Optic Neuropathy | Drug: Idebenone|Drug: Placebo | Santhera Pharmaceuticals | Phase 3 | null | 2014-08-21 |
NCT02887443 | Drug-Drug Interaction | Drug: Raxone (idebenone 150 mg)|Drug: Midazolam 2,5 mg | Santhera Pharmaceuticals | Phase 1 | 2016-09-01 | 2016-11-23 |
NCT02774005 | Leber's Hereditary Optic Neuropathy (LHON) | Drug: Idebenone | Santhera Pharmaceuticals | Phase 4 | 2016-05-01 | 2017-03-01 |
NCT02771379 | Leber's Hereditary Optic Neuropathy (LHON) | Drug: Idebenone | Santhera Pharmaceuticals | 2016-09-01 | 2017-03-01 | |
NCT01421381 | Leber's Hereditary Optic Neuropathy | Santhera Pharmaceuticals | 2011-09-01 | 2013-05-24 | ||
NCT00224640 | Friedreich Ataxia | Drug: Iron chelating intervention | Assistance Publique - H么pitaux de Paris | Phase 1|Phase 2 | 2005-03-01 | 2009-03-03 |
NCT03014908 | Type1diabetes | Other: Blood sampling | Hasselt University|Jessa Hospital | 2014-01-01 | 2017-01-06 | |
NCT03014856 | Obesity, Pediatric | Other: Blood sampling | Hasselt University|Jessa Hospital | 2012-05-01 | 2017-01-05 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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