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Flutamide

氟他米特,氟他胺,SCH 13521,SCH13521,SCH-13521

Flutamide是抗雄激素化合物，能与其活性代谢物一起与雄激素受体相结合，Ki为55 nM，可作用于前列腺癌。

目录号
EY0515
EY0515
纯度
99.25%
99.25%
规格
100 mg
500 mg
原价
180
280
售价
180
280
库存
现货
现货
订购
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  • 生物活性

    Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    ~1 μM

  • 动物实验

    5 毫克 每天两次，0.25毫升皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Simard J, et al. Mol Cell Endocrinol, 1986, 44(3), 261-270.
    [2] Fossa SD, Slee PH, Brausi M et al. J Clin Oncol. 19 :62-71 (2001).
    [3] Xie B, Tsao SW, Wong YC, Breast Cancer Res Treat. 58:227-39 (1999).

    分子式
    C11H11F3N2O3    		 分子量
    276.21    		 CAS号
    13311-84-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    55 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    55 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00006214 Prostate Cancer Drug: flutamide|Other: placebo Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 2 2000-08-01 2016-07-12
    NCT00699907 Ovarian Cancer Drug: flutamide University of Arizona|National Cancer Institute (NCI) Phase 2 2005-01-01 2014-12-11
    NCT00817739 Prostatic Neoplasms Drug: Leuprorelin|Drug: Flutamide Takeda Phase 2 1996-12-01 2015-07-27
    NCT00611923 Premenstrual Syndrome Drug: Flutamide|Drug: Placebo Weill Medical College of Cornell University|National Institute of Mental Health (NIMH) Phase 4 2005-02-01 2012-06-27
    NCT02918968 Prostate Cancer Drug: Enzalutamide|Drug: Flutamide|Other: Androgen deprivation therapy Astellas Pharma Inc|Medivation, Inc. Phase 4 2016-11-01 2017-02-12
    NCT01889199 Polycystic Ovary Syndrome (PCOS) Drug: Flutamide|Other: Placebo University of California, Los Angeles|University of Wisconsin, Madison|Oregon Health and Science University Phase 2 2013-04-01 2016-10-27
    NCT00930228 Polycystic Ovary Syndrome Drug: Flutamide|Drug: Placebo University of Virginia Phase 1 2009-01-01 2017-02-23
    NCT00450463 Prostate Cancer Drug: Sargramostim (GM-CSF, Leukine)|Drug: Flutamide (Eulexin)|Biological: PROSTVAC-F/ TRICOM|Biological: PROSTVAC-V/TRICOM National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 2 2007-02-19 2017-01-24
    NCT00002881 Prostate Cancer Drug: flutamide|Drug: goserelin acetate|Drug: leuprolide acetate|Drug: suramin|Drug: therapeutic hydrocortisone|Procedure: orchiectomy Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|Cancer and Leukemia Group B|Southwest Oncology Group Phase 3 1996-10-01 2010-11-06
    NCT00729560 Polycystic Ovary Syndrome Drug: Flutamide|Drug: Placebo Virginia Commonwealth University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2008-07-01 2014-09-05
    NCT00001266 Prostatic Neoplasm Drug: Suramin National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 2 1990-10-01 2008-03-03
    NCT00001521 Congenital Adrenal Hyperplasia|Growth Disorder Drug: Flutamide and Testolactone|Drug: Deslorelin Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) Phase 1 1996-02-02 2017-01-24
    NCT00003645 Prostate Cancer Drug: Flutamide|Drug: Leuprolide Acetate M.D. Anderson Cancer Center|National Cancer Institute (NCI)|Eastern Cooperative Oncology Group|AstraZeneca Phase 3 1999-06-14 2017-03-21
    NCT00104741 Prostate Cancer Drug: flutamide|Drug: triptorelin|Procedure: neoadjuvant therapy|Radiation: radiation therapy UNICANCER|National Cancer Institute (NCI) Phase 3 2004-07-01 2011-02-18
    NCT01428193 Polycystic Ovary Syndrome|Hyperandrogenism Drug: Flutamide|Drug: Progesterone|Drug: estrace University of Virginia|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2006-09-01 2015-08-25
    NCT02346578 Castration-resistant Prostate Cancer Drug: Enzalutamide|Drug: Flutamide Taro Iguchi, MD, PHD|Astellas Pharma Inc|Osaka City University 2015-01-01 2016-12-16
    NCT01122121 Prostatic Neoplasms, Locally Advanced Drug: Leuprorelin SR|Radiation: Radiotherapy|Drug: Flutamide Takeda Phase 3 2000-03-01 2015-07-27
    NCT00567580 Prostate Cancer Drug: bicalutamide|Drug: flutamide|Radiation: radiation therapy Radiation Therapy Oncology Group|National Cancer Institute (NCI)|Cancer and Leukemia Group B|NRG Oncology Phase 3 2008-02-01 2016-09-28
    NCT00003323 Prostate Cancer|Sexual Dysfunction and Infertility Drug: finasteride|Drug: flutamide|Other: quality-of-life assessment Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 2 1998-05-01 2016-07-01
    NCT00003124 Prostate Cancer Drug: flutamide|Drug: leuprolide acetate|Radiation: radiation therapy Herbert Irving Comprehensive Cancer Center|National Cancer Institute (NCI) Phase 2 1997-05-01 2014-01-03
    NCT00003734 Prostate Cancer Drug: flutamide|Drug: triptorelin|Radiation: radiation therapy St. Luke's Hospital, Ireland|National Cancer Institute (NCI) Phase 3 1998-12-01 2016-07-20

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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