Sertraline hydrochloride (盐酸舍曲林) 是选择性5羟色胺再吸收抑制剂(SSRI)。
Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Koe BK, et al. J Pharmacol Exp Ther, 1983, 226(3), 686-700.
[2] Löwe, B., et al. 2005. J Affect Disord. 87: 271-279.
[3] Khouzam, H.R., et al. 2003. Compr Ther. 29: 47-53.
分子式 C17H18Cl3N |
分子量 342.69 |
CAS号 79559-97-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >30 mg/mL |
Water <1 mg/mL |
Ethanol 10 mg/mL |
体内溶解度
NCT01032434 | Depression | Drug: sertraline | Guang Dong Provincial Mental Health Institute | 2009-12-01 | 2015-04-30 | |
NCT00864019 | Healthy | Drug: Sertraline HCl 100 mg tablets, single dose|Drug: Zoloft庐 100 mg tablets, single dose | Actavis Inc. | Phase 1 | 2004-08-01 | 2010-08-13 |
NCT00969852 | Healthy | Drug: Sertraline | Seoul National University Hospital|Ministry of Health, Welfare and Family Affairs|Korea National Enterprise for Clinical Trials | Phase 4 | 2009-07-01 | 2011-01-09 |
NCT01214382 | Roux en Y Gastric Bypass Surgery | Drug: Sertraline | North Dakota State University|National Institutes of Health (NIH) | Phase 3 | 2010-10-01 | 2016-04-04 |
NCT01267383 | Healthy | Drug: Sertraline | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-09-01 | 2012-01-10 |
NCT01267396 | Healthy | Drug: Sertraline | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-09-01 | 2012-01-10 |
NCT00605813 | Depression|Panic Disorder | Drug: Sertraline hydrochloride | Pfizer | 2007-09-01 | 2012-08-09 | |
NCT03068429 | Obsessive-Compulsive Disorder | Drug: Sertraline Hydrochloride | University of Sao Paulo | Phase 4 | 2016-12-01 | 2017-02-24 |
NCT02520726 | Post-traumatic Stress Disorder | Drug: Sertraline | University of Utah | Phase 4 | 2013-09-01 | 2016-10-24 |
NCT01802385 | Cryptococcal Meningitis|Fungal Meningitis | Drug: Sertraline | University of Minnesota - Clinical and Translational Science Institute|Infectious Disease Institute, Kampala, Uganda|National Institute of Neurological Disorders and Stroke (NINDS)|Mbarara University of Science and Technology|Ifakara Health Institute | Phase 3 | 2015-03-01 | 2016-12-06 |
NCT01699724 | Healthy | Drug: JZoloft|Drug: sertraline ODT|Drug: sertraline ODT | Pfizer | Phase 1 | 2012-09-01 | 2012-10-31 |
NCT02891278 | Acute Myeloid Leukemia | Drug: Sertraline|Drug: Cytosine arabinoside|Procedure: allogeneic stem cell transplantation | Mark G. Frattini|The Leukemia and Lymphoma Society|Columbia University | Phase 1 | 2016-07-01 | 2016-09-01 |
NCT00605917 | Panic Disorder | Drug: Sertraline hydrochloride | Pfizer | 2007-04-01 | 2012-08-20 | |
NCT02651623 | Healthy | Drug: Sertraline|Drug: Moxifloxacin|Drug: Drug - Placebo | Pfizer | Phase 1 | 2016-01-01 | 2016-10-11 |
NCT02385799 | Autism Spectrum Disorder | Drug: Sertraline Liquid Placebo|Drug: Sertraline | University of California, Davis|Health Resources and Services Administration (HRSA) | Phase 2 | 2015-02-01 | 2016-10-24 |
NCT02452983 | Myelodysplastic Syndromes | Drug: Sertraline|Procedure: Bone Marrow Aspirate/Biopsy | Gustavo Rivero|Baylor College of Medicine | Phase 1 | 2015-05-01 | 2017-02-05 |
NCT00368550 | Alcoholism | Drug: Sertraline|Drug: Placebo | UConn Health|National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 4 | 2004-02-01 | 2011-06-17 |
NCT01474746 | Fragile X Syndrome | Drug: Sertraline|Drug: Placebo | University of California, Davis | Phase 2 | 2012-01-01 | 2016-01-26 |
NCT00182078 | Posttraumatic Stress Disorder|Depression | Drug: Placebo|Drug: Sertraline | Massachusetts General Hospital | Phase 4 | 2002-11-01 | 2014-07-08 |
NCT01235195 | Healthy | Drug: sertraline hydrochloride|Drug: sertraline hydrochloride | Pfizer | Phase 1 | 2010-11-01 | 2012-05-17 |
NCT01524133 | Posttraumatic Stress Disorder | Drug: Sertraline|Behavioral: Prolonged Exposure Therapy | VA Ann Arbor Healthcare System|U.S. Army Medical Research and Materiel Command | Phase 4 | 2011-11-01 | 2016-06-16 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们