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Vancomycin HCl

盐酸万古霉素

Vancomycin hydrochloride是窄谱的糖肽抗菌剂。

目录号
EY0510
EY0510
纯度
99.26%
99.26%
规格
100 mg
500 mg
原价
240
620
售价
240
620
库存
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Vancomycin HCl is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Schilling A, Neuner E, Rehm SJ. Vancomycin: a 50-something-year-old antibiotic we still don't understand. Cleve Clin J Med. 2011 Jul;78(7):465-71.
    [2] Giuliano C, Haase KK, Hall R. Use of vancomycin pharmacokinetic-pharmacodynamic properties in the treatment of MRSA infections. Expert Rev Anti Infect Ther. 2010 Jan;8(1):95-106.
    [3] Rybak MJ, Lomaestro BM, Rotschafer JC et al. Therapeutic monitoring of vancomycin in adults summary of consensus recommendations from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2009 Nov;29(11):1275-9.

    分子式
    C66H76Cl3N9O24
    分子量
    1485.72
    CAS号
    1404-93-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    50 mM
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01427842 Vancomycin Therapy Drug: DEVINE vancomycin regimen The Canberra Hospital Phase 2 2011-08-01 2011-09-01
    NCT02096536 Neonatal Infection Drug: Vancomycin Universitaire Ziekenhuizen Leuven Phase 4 2014-04-01 2015-11-02
    NCT01623817 Infection Drug: Vancomycin HCL Samsung Medical Center 2012-06-01 2012-06-19
    NCT03046901 Primary Sclerosing Cholangitis|Post- Orthotopic Liver Transplantation Drug: Vancomycin Ochsner Health System 2016-12-07 2017-02-07
    NCT01619982 Congenital Heart Diseases|Aortic Valve Disorder Drug: Cefazolin pre-operative prophylaxis|Drug: Vancomycin hydrochloride Stanford University Phase 4 2012-02-01 2016-02-04
    NCT02051595 Infection Other: Vancomycin concentrations University of Florida Early Phase 1 2014-04-01 2015-08-31
    NCT01322386 Primary Sclerosing Cholangitis|Biliary Atresia Drug: Vancomycin Stanford University Phase 1 2007-05-01 2016-04-18
    NCT02020031 Arthropathy of Knee Joint Drug: Vancomycin Mayo Clinic|Vidacare Corporation Phase 2|Phase 3 2013-12-01 2016-10-04
    NCT00861887 Clostridium Difficile Colitis Drug: Standard Vancomycin|Drug: Extended Vancomycin William Beaumont Hospitals|Beaumont Hospital 2009-02-01 2016-12-13
    NCT02284126 Infection|Surgery|Nervous System Diseases Drug: Vancomycin Columbia University|Agency for Healthcare Research and Quality (AHRQ)|Cornell University|Icahn School of Medicine at Mount Sinai Phase 3 2014-10-01 2017-02-15
    NCT02631408 Spinal Fusion Acquired Drug: Vancomycin Orthopedic Hospital Vienna Speising Phase 4 2015-08-01 2016-09-26
    NCT01802073 Primary Sclerosing Cholangitis Drug: Oral Vancomycin Stanford University Phase 3 2012-01-01 2016-10-12
    NCT01509339 Cystic Fibrosis|Methicillin-resistant Staphylococcus Aureus Drug: Vancomycin Case Western Reserve University|Cystic Fibrosis Foundation Therapeutics Phase 1 2012-01-01 2013-01-25
    NCT02764359 Infection|Sepsis|Obesity Drug: IV vancomycin CAMC Health System 2016-05-01 2016-06-20
    NCT01720940 Infections Requiring Prolonged Duration (>10 Days) of Vancomycin Drug: continuous vancomycin infusion|Drug: intermittent vancomycin infusion National University Hospital, Singapore|Tan Tock Seng Hospital 2012-10-01 2012-11-01
    NCT01346059 Colitis Drug: Vancomycin|Drug: Saline Marc Grodsky|William Beaumont Hospitals 2011-04-01 2012-09-15
    NCT02663596 Pediatric Continuous Renal Replacement Therapy|Dialysis|Renal Failure Drug: Vancomycin Drexel University|The Center for Pediatric Pharmacotherapy, LLC Phase 1 2017-01-01 2017-03-07
    NCT01786161 MRSA - Methicillin Resistant Staphylococcus Aureus Infection Drug: Vancomycin continuous infusion|Drug: Vancomycin intermittent dosing interval Massachusetts General Hospital Phase 4 2013-09-01 2016-11-30
    NCT02400112 Fractures, Open|Surgical Wound Infection Drug: Vancomycin University of Tennessee Phase 4 2015-03-01 2015-03-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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