Vancomycin hydrochloride是窄谱的糖肽抗菌剂。
Vancomycin HCl is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Schilling A, Neuner E, Rehm SJ. Vancomycin: a 50-something-year-old antibiotic we still don't understand. Cleve Clin J Med. 2011 Jul;78(7):465-71.
[2] Giuliano C, Haase KK, Hall R. Use of vancomycin pharmacokinetic-pharmacodynamic properties in the treatment of MRSA infections. Expert Rev Anti Infect Ther. 2010 Jan;8(1):95-106.
[3] Rybak MJ, Lomaestro BM, Rotschafer JC et al. Therapeutic monitoring of vancomycin in adults summary of consensus recommendations from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2009 Nov;29(11):1275-9.
分子式 C66H76Cl3N9O24 |
分子量 1485.72 |
CAS号 1404-93-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 50 mM |
Ethanol <1 mg/mL |
体内溶解度
NCT01427842 | Vancomycin Therapy | Drug: DEVINE vancomycin regimen | The Canberra Hospital | Phase 2 | 2011-08-01 | 2011-09-01 |
NCT02096536 | Neonatal Infection | Drug: Vancomycin | Universitaire Ziekenhuizen Leuven | Phase 4 | 2014-04-01 | 2015-11-02 |
NCT01623817 | Infection | Drug: Vancomycin HCL | Samsung Medical Center | 2012-06-01 | 2012-06-19 | |
NCT03046901 | Primary Sclerosing Cholangitis|Post- Orthotopic Liver Transplantation | Drug: Vancomycin | Ochsner Health System | 2016-12-07 | 2017-02-07 | |
NCT01619982 | Congenital Heart Diseases|Aortic Valve Disorder | Drug: Cefazolin pre-operative prophylaxis|Drug: Vancomycin hydrochloride | Stanford University | Phase 4 | 2012-02-01 | 2016-02-04 |
NCT02051595 | Infection | Other: Vancomycin concentrations | University of Florida | Early Phase 1 | 2014-04-01 | 2015-08-31 |
NCT01322386 | Primary Sclerosing Cholangitis|Biliary Atresia | Drug: Vancomycin | Stanford University | Phase 1 | 2007-05-01 | 2016-04-18 |
NCT02020031 | Arthropathy of Knee Joint | Drug: Vancomycin | Mayo Clinic|Vidacare Corporation | Phase 2|Phase 3 | 2013-12-01 | 2016-10-04 |
NCT00861887 | Clostridium Difficile Colitis | Drug: Standard Vancomycin|Drug: Extended Vancomycin | William Beaumont Hospitals|Beaumont Hospital | 2009-02-01 | 2016-12-13 | |
NCT02284126 | Infection|Surgery|Nervous System Diseases | Drug: Vancomycin | Columbia University|Agency for Healthcare Research and Quality (AHRQ)|Cornell University|Icahn School of Medicine at Mount Sinai | Phase 3 | 2014-10-01 | 2017-02-15 |
NCT02631408 | Spinal Fusion Acquired | Drug: Vancomycin | Orthopedic Hospital Vienna Speising | Phase 4 | 2015-08-01 | 2016-09-26 |
NCT01802073 | Primary Sclerosing Cholangitis | Drug: Oral Vancomycin | Stanford University | Phase 3 | 2012-01-01 | 2016-10-12 |
NCT01509339 | Cystic Fibrosis|Methicillin-resistant Staphylococcus Aureus | Drug: Vancomycin | Case Western Reserve University|Cystic Fibrosis Foundation Therapeutics | Phase 1 | 2012-01-01 | 2013-01-25 |
NCT02764359 | Infection|Sepsis|Obesity | Drug: IV vancomycin | CAMC Health System | 2016-05-01 | 2016-06-20 | |
NCT01720940 | Infections Requiring Prolonged Duration (>10 Days) of Vancomycin | Drug: continuous vancomycin infusion|Drug: intermittent vancomycin infusion | National University Hospital, Singapore|Tan Tock Seng Hospital | 2012-10-01 | 2012-11-01 | |
NCT01346059 | Colitis | Drug: Vancomycin|Drug: Saline | Marc Grodsky|William Beaumont Hospitals | 2011-04-01 | 2012-09-15 | |
NCT02663596 | Pediatric Continuous Renal Replacement Therapy|Dialysis|Renal Failure | Drug: Vancomycin | Drexel University|The Center for Pediatric Pharmacotherapy, LLC | Phase 1 | 2017-01-01 | 2017-03-07 |
NCT01786161 | MRSA - Methicillin Resistant Staphylococcus Aureus Infection | Drug: Vancomycin continuous infusion|Drug: Vancomycin intermittent dosing interval | Massachusetts General Hospital | Phase 4 | 2013-09-01 | 2016-11-30 |
NCT02400112 | Fractures, Open|Surgical Wound Infection | Drug: Vancomycin | University of Tennessee | Phase 4 | 2015-03-01 | 2015-03-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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