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Mercaptopurine

6-巯基嘌呤,6-MP

Mercaptopurine是免疫抑制剂。

目录号
EY0508
EY0508
EY0508
纯度
99.19%
99.19%
99.19%
规格
50 mg
100 mg
500 mg
原价
420
620
960
售价
420
620
960
库存
现货
现货
现货
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  • 生物活性

    Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Sahasranaman S, et al. Eur J Clin Pharmacol, 2008, 64(8), 753-767.
    [2] Naguib, F., et al. 1995. Biochem. Pharmacol. 50: 1685-1693.

    分子式
    C5H4N4S    		 分子量
    152.18    		 CAS号
    50-44-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    30 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01906671 Acute Lymphoblastic Leukemia|6-mercaptopurine Therapy Drug: Xaluprine|Drug: Puri-Nethol Kjeld Schmiegelow|Danish Cancer Society|Rigshospitalet, Denmark Phase 4 2013-06-01 2016-10-06
    NCT01324336 Acute Lymphoblastic Leukemia Drug: 6-Mercaptopurine Children's Mercy Hospital Kansas City|Midwest Cancer Alliance|Experimental Therapeutics in Pediatric Oncology Program at The Children's Mercy Hospitals and Clinics 2011-07-01 2013-05-31
    NCT00774982 Crohns Disease Drug: Delayed Release 6 mercaptopurine|Drug: 6 Mercaptopurine Teva GTC Phase 1 2008-12-01 2009-07-16
    NCT01094613 Crohn's Disease Drug: Delayed Release 6 mercaptopurine|Drug: 6 Mercaptopurine Teva GTC Phase 1|Phase 2 2010-11-01 2013-03-06
    NCT00548431 Leukemia, Lymphocytic, Acute Drug: 6-mercaptopurine Rigshospitalet, Denmark Phase 2 2007-12-01 2016-11-19
    NCT01697020 Acute Lymphoblastic Leukemia Drug: Mercaptopurine 20mg/ml oral suspension|Drug: Mercaptopurine 50mg tablet Nova Laboratories Limited Phase 1 2012-09-01 2013-11-28
    NCT02141100 Non-Hodgkin Lymphoma Drug: 6-thioguanine Kjeld Schmiegelow|Aalborg Universitetshospital|Aarhus University Hospital Skejby|Odense University Hospital|Rigshospitalet, Denmark Phase 1|Phase 2 2014-07-01 2016-10-06
    NCT01432145 Breast Cancer|Ovarian Cancer Drug: 6-Mercaptopurine|Drug: Methotrexate University of Oxford Phase 2 2011-05-01 2015-05-27
    NCT01433432 Crohn's Disease Drug: 80 mg DR-6MP Teva GTC Phase 2 2011-10-01 2013-03-05
    NCT00648336 Healthy Drug: Mercaptopurine 50 mg|Drug: Purinethol庐 Tablets 50 mg Mylan Pharmaceuticals Phase 1 2003-11-01 2008-03-31
    NCT00602134 Acute Lymphoblastic Leukemia Drug: 6-Mercaptopurine Roxane Laboratories 2002-11-01 2008-02-05
    NCT01503632 Childhood Acute Lymphoblastic Leukemia in Remission Behavioral: behavioral intervention|Drug: mercaptopurine|Procedure: standard follow-up care|Behavioral: compliance monitoring|Other: questionnaire administration|Other: laboratory biomarker analysis Children's Oncology Group|National Cancer Institute (NCI) Phase 3 2012-02-01 2016-09-23
    NCT02912676 Acute Lymphoblastic Leukemia Drug: Thioguanine (oral) Kjeld Schmiegelow|Danish Child Cancer Foundation|Nordic Society for Pediatric Hematology and Oncology|Rigshospitalet, Denmark Phase 1|Phase 2 2016-10-01 2016-11-03
    NCT00816049 Acute Lymphoblastic Leukemia Drug: 6MPindividualized|Drug: 6MPfixed Rigshospitalet, Denmark|Nordic Society for Pediatric Hematology and Oncology Phase 3 2009-06-01 2012-05-22
    NCT02910245 Colitis, Ulcerative Drug: Mercaptopurine (Purinethol)|Drug: Placebo|Drug: Mesalamine|Drug: Prednisone Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|ZonMw: The Netherlands Organisation for Health Research and Development Phase 3 2016-10-01 2016-10-17
    NCT03022747 Lymphoblastic Leukemia, Acute, Childhood Drug: Allopurinol|Drug: Standard treatment Vastra Gotaland Region Phase 2 2017-01-01 2017-01-11
    NCT02046694 Acute Lymphoblastic Leukemia (ALL) Drug: Allopurinol Sidney Kimmel Comprehensive Cancer Center Phase 1 2014-01-01 2017-03-06
    NCT00003934 Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Promyelocytic Leukemia (M3)|Childhood Acute Promyelocytic Leukemia (M3)|Untreated Adult Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies Drug: tretinoin|Drug: daunorubicin hydrochloride|Drug: cytarabine|Drug: mercaptopurine|Drug: methotrexate|Drug: arsenic trioxide National Cancer Institute (NCI) Phase 3 1999-06-01 2013-06-04
    NCT00268528 Childhood Acute Lymphoblastic Leukemia in Remission Behavioral: compliance monitoring|Other: study of socioeconomic and demographic variables|Drug: mercaptopurine tablet|Drug: methotrexate Children's Oncology Group|National Cancer Institute (NCI) 2005-05-01 2017-02-07
    NCT00089349 Recurrent Childhood Acute Lymphoblastic Leukemia Biological: alemtuzumab|Drug: methotrexate|Drug: mercaptopurine National Cancer Institute (NCI) Phase 2 2004-07-01 2013-06-04
    NCT01629628 Crohn Disease Drug: Adalimumab|Drug: 6 Mercaptopurine Tel-Aviv Sourasky Medical Center|Abbott Phase 3 2012-07-01 2012-06-25
    NCT00492856 Leukemia Drug: mercaptopurine|Drug: methotrexate|Drug: tretinoin Southwest Oncology Group|National Cancer Institute (NCI) Phase 3 2007-06-01 2016-04-14
    NCT00287170 Crohn's Disease Drug: Delayed Release 6MP or Calcitriol vs. Purinethol Teva GTC Phase 1|Phase 2 2006-07-01 2008-07-03
    NCT02281799 Pancreatitis|Inflammatory Bowel Diseases Drug: Azathioprine Shaare Zedek Medical Center|Sydney Children's Network|Christchurch Hospital Phase 4 2015-03-01 2016-04-13

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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