Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Harms, N., et al.: J. Med. Pharm. Chem., 2, 57 (1960)
分子式 C24H31NO8 |
分子量 461.5 |
CAS号 4682-36-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 90 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT02423395 | Liver Cirrhosis|Muscle Cramps | Drug: orphenadrine|Drug: Placebo | Sherief Abd-Elsalam|Tanta University | Phase 3 | 2015-01-01 | 2016-05-09 |
NCT02665286 | Low Back Pain | Drug: Orphenadrine|Drug: Methocarbamol|Drug: Naproxen|Drug: Placebo | Montefiore Medical Center | Phase 4 | 2016-03-01 | 2016-09-06 |
NCT02449369 | Unilateral Knee Arthroplasty | Drug: Preop acetaminophen IV|Drug: Preop orphenadrine IV|Drug: Postop oral oxycodone & acetaminophen|Drug: Postop hydromorphone IV|Drug: Postop oral orphenadrine|Drug: Postop oral oxycodone|Drug: Postop acetaminophen IV|Drug: Postop orphenadrine IV | Florida Hospital|Sagent Pharmaceuticals, Inc. | Phase 4 | 2015-04-01 | 2016-02-03 |
NCT02985671 | Postural Low Back Pain|Mechanical Low Back Pain | Drug: orphenadrine, acetaminophen, caffeine and diclofenac sodium|Drug: Voltaren庐 (diclofenac sodium 50mg) | Ache Laboratorios Farmaceuticos S.A. | Phase 3 | 2017-06-01 | 2017-02-14 |
NCT02485145 | Osteoarthritis of the Hands | Drug: A/B|Drug: Placebo|Drug: B/A | Transdermal Therapeutics, Inc.|Albert Einstein College of Medicine, Inc.|Montefiore Medical Center | Early Phase 1 | 2015-07-01 | 2015-06-25 |
NCT02958566 | Colon Cancer|Colon Diverticulosis|Colonic Neoplasms|Colonic Diverticulitis|Pain, Postoperative|Ileus|Ileus Paralytic|Ileus; Mechanical|Constipation Drug Induced|Constipation|Rectum Cancer|Rectum Neoplasm | Drug: Acetaminophen|Drug: Gabapentin|Drug: Orphenadrine|Drug: Lidocaine|Drug: Marcaine|Drug: Ketamine|Drug: Methadone|Drug: Tramadol|Drug: Ketorolac|Drug: Morphine Sulfate|Drug: Fentanyl|Drug: Dilaudid|Drug: Hydrocodone-Acetaminophen Tab 5-325 MG|Drug: Morphine Sulfate|Drug: Fentanyl|Drug: Dilaudid|Drug: HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET | University of Illinois College of Medicine at Peoria | Phase 4 | 2017-01-01 | 2017-03-16 |
NCT01263652 | Pain Relief | Drug: Diclofenac hydroxyethylpyrrolidine|Drug: orphenadrine|Drug: Tramadol|Drug: Dipyrone | Western Galilee Hospital-Nahariya | 2010-12-01 | 2010-12-16 | |
NCT02445599 | Pain|Inadequate or Impaired Respiratory Function | Drug: Diclofenac|Drug: Midazolam|Drug: Atropine|Drug: bucain + fentanyl|Drug: Nalbuphine|Drug: Diclofenac|Drug: Metamizole-sodium|Drug: Tramadol | University of Debrecen | Phase 4 | 2014-04-01 | 2017-03-08 |
NCT02456116 | Pain, Postoperative | Device: acupuncture/PCA/NSAID|Device: sham acupuncture/PCA/NSAID|Other: PCA/NSAID | Medical University of Vienna|Medical Scientific Fund of the Mayor of Vienna | 2012-09-01 | 2015-05-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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