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Orphenadrine Citrate

枸橼酸奥芬那君,柠檬酸邻甲苯海拉明,Norflex,Disipal

Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。

目录号
EY0505
EY0505
纯度
99.56%
99.56%
规格
50 mg
100 mg
原价
350
620
售价
350
620
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Harms, N., et al.: J. Med. Pharm. Chem., 2, 57 (1960)

    分子式
    C24H31NO8
    分子量
    461.5
    CAS号
    4682-36-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    90 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02423395 Liver Cirrhosis|Muscle Cramps Drug: orphenadrine|Drug: Placebo Sherief Abd-Elsalam|Tanta University Phase 3 2015-01-01 2016-05-09
    NCT02665286 Low Back Pain Drug: Orphenadrine|Drug: Methocarbamol|Drug: Naproxen|Drug: Placebo Montefiore Medical Center Phase 4 2016-03-01 2016-09-06
    NCT02449369 Unilateral Knee Arthroplasty Drug: Preop acetaminophen IV|Drug: Preop orphenadrine IV|Drug: Postop oral oxycodone & acetaminophen|Drug: Postop hydromorphone IV|Drug: Postop oral orphenadrine|Drug: Postop oral oxycodone|Drug: Postop acetaminophen IV|Drug: Postop orphenadrine IV Florida Hospital|Sagent Pharmaceuticals, Inc. Phase 4 2015-04-01 2016-02-03
    NCT02985671 Postural Low Back Pain|Mechanical Low Back Pain Drug: orphenadrine, acetaminophen, caffeine and diclofenac sodium|Drug: Voltaren庐 (diclofenac sodium 50mg) Ache Laboratorios Farmaceuticos S.A. Phase 3 2017-06-01 2017-02-14
    NCT02485145 Osteoarthritis of the Hands Drug: A/B|Drug: Placebo|Drug: B/A Transdermal Therapeutics, Inc.|Albert Einstein College of Medicine, Inc.|Montefiore Medical Center Early Phase 1 2015-07-01 2015-06-25
    NCT02958566 Colon Cancer|Colon Diverticulosis|Colonic Neoplasms|Colonic Diverticulitis|Pain, Postoperative|Ileus|Ileus Paralytic|Ileus; Mechanical|Constipation Drug Induced|Constipation|Rectum Cancer|Rectum Neoplasm Drug: Acetaminophen|Drug: Gabapentin|Drug: Orphenadrine|Drug: Lidocaine|Drug: Marcaine|Drug: Ketamine|Drug: Methadone|Drug: Tramadol|Drug: Ketorolac|Drug: Morphine Sulfate|Drug: Fentanyl|Drug: Dilaudid|Drug: Hydrocodone-Acetaminophen Tab 5-325 MG|Drug: Morphine Sulfate|Drug: Fentanyl|Drug: Dilaudid|Drug: HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET University of Illinois College of Medicine at Peoria Phase 4 2017-01-01 2017-03-16
    NCT01263652 Pain Relief Drug: Diclofenac hydroxyethylpyrrolidine|Drug: orphenadrine|Drug: Tramadol|Drug: Dipyrone Western Galilee Hospital-Nahariya 2010-12-01 2010-12-16
    NCT02445599 Pain|Inadequate or Impaired Respiratory Function Drug: Diclofenac|Drug: Midazolam|Drug: Atropine|Drug: bucain + fentanyl|Drug: Nalbuphine|Drug: Diclofenac|Drug: Metamizole-sodium|Drug: Tramadol University of Debrecen Phase 4 2014-04-01 2017-03-08
    NCT02456116 Pain, Postoperative Device: acupuncture/PCA/NSAID|Device: sham acupuncture/PCA/NSAID|Other: PCA/NSAID Medical University of Vienna|Medical Scientific Fund of the Mayor of Vienna 2012-09-01 2015-05-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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