Home > others & > Rifabutin

Rifabutin

利福布汀,LM427,Ansamycin,Mycobutin

Rifabutin是半合成的安莎霉素抗生素,具有抗分枝杆菌特性。

目录号
EY0504
EY0504
EY0504
纯度
99.32%
99.32%
99.32%
规格
25 mg
50 mg
100 mg
原价
260
460
758.00
售价
260
460
758.00
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Rifabutin is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kunin CM, et al. Clin Infect Dis, 1996, 22 Suppl 1, S3-13.
    [2] Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988),
    [3] Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989)

    分子式
    C46H62N4O11
    分子量
    847
    CAS号
    72559-06-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    60 mg/mL
    Water
    <1 mg/mL
    Ethanol
    40 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01259219 Children With Confirmed HIV Infection|Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose|Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment Drug: Mycobutin Harriet Shezi Children's Clinic Phase 1 2010-11-01 2010-12-13
    NCT01663168 HIV|Tuberculosis Drug: Rifabutin Justine Boles|Abbott|Medical Research Council Phase 2 2011-12-01 2012-08-08
    NCT00810446 Non-tuberculous Mycobacterial Diseases (Including MAC Disease)|Tuberculosis|Inhibition of Disseminated Mycobacterium Avium Complex (MAC) Disease Associated With HIV Infections Drug: rifabutin Pfizer 2009-06-01 2017-03-06
    NCT00810407 Tuberculosis|Non-tuberculous Mycobacterial Diseases (Including MAC Disease) Drug: rifabutin Pfizer 2008-11-01 2016-09-20
    NCT02415985 HIV|Tuberculosis Drug: Lopinavir/r will be supplied by NHSO/GPO|Drug: Rifabutin The HIV Netherlands Australia Thailand Research Collaboration|Bamrasnaradura Infectious Diseases Institute|Chulalongkorn University Phase 2 2015-06-01 2017-02-22
    NCT00651066 HIV Infections|Tuberculosis Drug: rifabutin in combination with lopinavir boosted by ritonavir - dosing schedule 1|Drug: rifabutin in combination with lopinavir boosted by ritonavir - dosing schedule 2 French National Agency for Research on AIDS and Viral Hepatitis|French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) Phase 2 2010-06-01 2013-07-16
    NCT01341184 Tuberculosis Drug: Rifabutin|Drug: Rifampin|Drug: TMC207 National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2011-10-01 2013-04-25
    NCT01894776 HIV Infection|HIV-1 Infection|Mycobacterium Avium Complex (MAC) Drug: Rifabutin|Drug: Maraviroc Ottawa Hospital Research Institute|Pfizer Phase 1 2013-06-01 2015-03-02
    NCT00640887 HIV Infections|Tuberculosis Drug: rifabutin in combination with efavirenz|Drug: rifabutin in combination with nevirapine|Drug: rifabutin in combination with lopinavir/ritonavir French National Agency for Research on AIDS and Viral Hepatitis Phase 2 2009-02-01 2011-06-17
    NCT01615614 Healthy Drug: Rilpivirine|Drug: Rifabutin Janssen R&D Ireland Phase 1 2012-04-01 2014-03-27
    NCT00869518 Staphylococcus Aureus|HIV Infections Drug: rifabutin plus trimethoprim sulfamethoxazole|Drug: placebo plus trimethoprim-sulfamethoxazole University of California, San Francisco Phase 2 2009-07-01 2014-04-23
    NCT00598897 Mycobacterium Avium Complex Lung Disease Drug: clarithromycin, rifabutin The University of Texas Health Science Center at Tyler|Abbott|Pfizer Phase 4 1995-08-01 2008-01-11
    NCT02251171 Healthy Drug: Tipranavir|Drug: Ritonavir|Drug: Rifabutin Boehringer Ingelheim Phase 1 2003-08-01 2014-09-25
    NCT00925535 Healthy Volunteers Drug: Lersivirine|Drug: Rifabutin|Drug: Lersivirine|Drug: Rifabutin Pfizer Phase 1 2010-05-01 2010-09-17
    NCT00023400 HIV Infections|Tuberculosis Drug: Nelfinavir|Drug: Rifabutin Centers for Disease Control and Prevention|VA Office of Research and Development Phase 4 2000-02-01 2005-09-01
    NCT00023413 HIV Infections|Tuberculosis Drug: Rifabutin|Drug: Efavirenz Centers for Disease Control and Prevention|VA Office of Research and Development Phase 2 1999-11-01 2012-06-04
    NCT00023348 HIV Infections|Tuberculosis Drug: Isoniazid|Drug: Rifabutin Centers for Disease Control and Prevention|VA Office of Research and Development Phase 2|Phase 3 1999-07-01 2005-09-09
    NCT01231542 Infection, Human Immunodeficiency Virus Drug: GSK1349572|Drug: Rifampin|Drug: Rifabutin ViiV Healthcare|Shionogi|GlaxoSmithKline Phase 1 2011-05-01 2011-12-21
    NCT00598962 Mycobacterium Avium Complex Drug: Azithromycin, Rifabutin The University of Texas Health Science Center at Tyler|Pfizer Phase 4 1994-12-01 2008-01-11
    NCT00743470 HIV|Tuberculosis Drug: lopinavir/ritonavir|Drug: rifabutin Abbott Phase 1 2008-08-01 2010-10-29
    NCT02138084 HIV/AIDS Drug: BMS-663068|Drug: Rifabutin|Drug: Ritonavir Bristol-Myers Squibb Phase 1 2014-05-01 2014-09-10

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :