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Sulfadoxine

磺胺多辛,周效磺胺,Sulphadoxine

Sulfadoxine (磺胺多辛; Sulphadoxine) 是长效的磺胺类化合物，常与pyrimethamine结合起到抗疟疾作用。

目录号
EY0498
EY0498
纯度
99.55%
99.55%
规格
100 mg
500 mg
原价
160
340
售价
160
340
库存
现货
现货
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  • 生物活性

    Sulfadoxine is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Höfler, W. 1980. Dtsch. Med. Wochenschr. 105: 350-351.
    [2] Klinkaewnarong, W., et al. 1985. Southeast Asian J. Trop. Med. Public Health. 16: 296-301.

    分子式
    C12H14N4O4S    		 分子量
    310.33    		 CAS号
    2447-57-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01328990 Malaria Drug: sulfadoxine-pyrimethamine plus amodiaquine London School of Hygiene and Tropical Medicine|Cheikh Anta Diop University, Senegal Phase 1|Phase 2 2011-04-01 2011-09-16
    NCT01184911 Intermittent Preventive Treatment|Placental Malaria Drug: Sulfadoxine-pyrimethamine University of California, San Francisco|Centers for Disease Control and Prevention|Uganda Malaria Surveillance Project Phase 4 2010-10-01 2015-03-03
    NCT00380146 Malaria Drug: sulfadoxine-pyrimethamine Professor Karen I Barnes|Global Fund|Medical Research Council, South Africa|University of Cape Town 2006-09-01 2016-10-25
    NCT00331708 Malaria Drug: Artesunate plus sulfadoxine-pyrimethamine Professor Karen I Barnes|Global Fund|Medical Research Council, South Africa|University of Cape Town 2006-04-01 2016-10-25
    NCT00399074 Sickle Cell Anemia|Malaria Drug: sulfadoxine pyrimethamine Makerere University Phase 3 2006-10-01 2009-07-01
    NCT00206739 Malaria|Anemia Drug: Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg) Bernhard Nocht Institute for Tropical Medicine|German Federal Ministry of Education and Research|Deutscher Akademischer Austausch Dienst|The Volkswagen Foundation Phase 4 2003-01-01 2010-03-29
    NCT01120145 Malaria in Pregnancy Centers for Disease Control and Prevention|University of Malawi College of Medicine 2010-03-01 2013-02-05
    NCT00453856 Malaria Drug: Sulfadoxine Pyrimethamine Albert Schweitzer Hospital|Bill and Melinda Gates Foundation Phase 4 2007-03-01 2007-08-08
    NCT01115439 Falciparum Malaria Drug: artesunate plus sulfadoxine-pyrimethamine (AS+SP) University of Oxford|National Malaria and Leishmaniasis Control Program, Afghanistan|World Health Organization 2010-03-01 2012-07-11
    NCT00131235 Malaria|Sexually Transmitted Diseases|Preterm Birth|Pregnancy Drug: Sulfadoxine-pyrimethamine treatment twice during pregnancy|Drug: Sulfadoxine-pyrimethamine at 4-week intervals|Drug: Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice University of Tampere|Academy of Finland|Foundation for Paediatric Research, Finland Phase 3 2003-12-01 2014-01-21
    NCT01707199 Uncomplicated P. Falciparum Malaria Drug: Artesunate + Sulphadoxine-pyrimethamine University of Oxford|World Health Organization 2012-10-01 2013-08-27
    NCT00167739 Malaria Drug: Quinine plus sulfadoxine-pyrimethamine Albert Schweitzer Hospital Phase 4 2003-04-01 2005-09-19
    NCT00125489 Malaria|Plasmodium Falciparum Malaria Drug: chloroquine sulfate|Drug: sulfadoxine/pyrimethamine National Institute of Allergy and Infectious Diseases (NIAID) Phase 4 2005-05-01 2010-08-26
    NCT00623155 Malaria Drug: Seasonal IPT in children - Sulfadoxine-pyrimethamine University of Bamako|World Health Organization 2002-07-01 2008-02-22
    NCT00120809 Malaria Drug: Sulfadoxine-pyrimethamine London School of Hygiene and Tropical Medicine|Medical Research Council Unit, The Gambia|Department of State for Health and Social Welfare, The Gambia Phase 3 2002-07-01 2017-01-11
    NCT00137553 Malaria, Falciparum Drug: Sulfadoxine-pyrimethamine (Fansidar) Bandim Health Project Phase 4 2001-05-01 2010-03-15
    NCT00130065 Malaria Drug: Sulfadoxine-pyrimethamine/folic acid|Drug: Sulfadoxine-pyrimethamine/placebo Centers for Disease Control and Prevention|Kenya Medical Research Institute|Kenya Ministry of Health Phase 4 2003-11-01 2012-09-26
    NCT02527005 Malaria|Pregnant|HIV Drug: Sulphadoxine-pyrimethamine|Drug: Azithromycin University of Ibadan Phase 1 2015-09-01 2015-08-17
    NCT00126906 Malaria, Falciparum|HIV Infections Drug: Monthly sulfadoxine/pyrimethamine|Drug: 2-dose sulfadoxine/pyrimethamine Centers for Disease Control and Prevention|Ministry of Health and Population, Malawi 2002-10-01 2005-08-22
    NCT00486694 Malaria, Vivax Drug: Sulfadoxine-pyrimethamine + artesunate|Drug: Chloroquine London School of Hygiene and Tropical Medicine Phase 2 2004-03-01 2007-06-13

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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