Home > Carbonic Anhydrase & > Topiramate

Topiramate

托吡酯,托佩马特,MCN 4853RWJ 17021,RWJ17021,RWJ-17021,Topamax,Epitomax

Topiramate 是镇痉化合物，能拮抗GluR5受体，还可作为GABA受体介导的电流阳性变构调节剂。

目录号
EY0497
EY0497
纯度
99.43%
99.43%
规格
25 mg
100 mg
原价
128.00
498.00
售价
128.00
498.00
库存
现货
现货
订购
订购
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  • 生物活性

    Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Taverna S, et al. J Pharmacol Exp Ther, 1999, 288(3), 960-968.
    [2] Dodgson et al (2000) Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia 41 S35. Gryder and Rogawski (2003)

    分子式
    C12H21NO8S    		 分子量
    339.36    		 CAS号
    97240-79-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    68 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    68 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02169830 Migraine Disorders Drug: nortriptyline|Drug: Topiramate St. Louis University 2014-06-01 2016-11-30
    NCT00606411 Sleep-Related Eating Disorder Drug: Topiramate or Placebo Massachusetts General Hospital Early Phase 1 2008-01-01 2016-03-22
    NCT00550394 Bipolar Disorder|Alcohol Abuse Drug: quetiapine + placebo|Drug: Quetiapine + Topiramate University of Cincinnati|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 4 2008-04-01 2014-10-01
    NCT00300742 Alcohol Dependence|Binge Eating Drug: Topiramate University of Virginia Phase 2 2006-03-01 2012-02-06
    NCT01135602 Alcohol Dependence Drug: Topiramate Chiang Mai University Phase 4 2010-07-01 2011-08-12
    NCT00846495 Migraine Drug: topiramate|Drug: frovatriptan Clinvest|Endo Pharmaceuticals|Cady, Roger, M.D. Phase 4 2009-08-01 2012-01-11
    NCT01145677 Alcohol Dependence Drug: Topiramate Chiang Mai University Phase 2|Phase 3 2010-06-01 2011-06-22
    NCT01682681 Epilepsy Drug: Topiramate Janssen Korea, Ltd., Korea Phase 4 2007-07-01 2013-08-21
    NCT01408641 Alcohol Dependence|Alcoholism|Alcohol Abuse|Alcohol Use Disorder|PTSD|Posttraumatic Stress Disorder Drug: Topiramate|Drug: Placebo University of Maryland|VA Office of Research and Development 2012-09-01 2012-09-10
    NCT00394095 Bipolar Disorder|Weight Gain Drug: Topiramate|Drug: Placebo University of Cincinnati|Eli Lilly and Company Phase 4 2006-12-01 2013-04-03
    NCT00626925 Alcohol Drinking Drug: topiramate|Drug: placebo UConn Health|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Center for Research Resources (NCRR) Phase 4 2008-02-01 2016-08-02
    NCT00203463 PTSD Drug: topiramate Tuscaloosa Research & Education Advancement Corporation|Ortho-McNeil Janssen Scientific Affairs, LLC Phase 4 2001-07-01 2009-07-28
    NCT02808533 Schizophrenia, Schizoaffective Disorder Drug: Topiramate|Other: Placebo Centre for Addiction and Mental Health|Ontario Ministry of Health and Long Term Care 2016-04-01 2017-01-17
    NCT00902473 Healthy Drug: Topiramate Ranbaxy Laboratories Limited|Ranbaxy Inc. 2001-09-01 2009-05-14
    NCT01110434 Cannabis Abuse|Cannabis Dependence Drug: Topiramate|Drug: Placebo Brown University|National Institute on Drug Abuse (NIDA) Phase 2 2009-12-01 2012-07-11
    NCT01641445 Alcohol Drinking Drug: Topiramate|Drug: Placebo Brown University Phase 1|Phase 2 2012-07-01 2016-01-11
    NCT00901784 Healthy Drug: Topiramate Ranbaxy Laboratories Limited|Ranbaxy Inc. 2001-09-01 2009-06-17
    NCT02138058 Compulsive Shopping Drug: Topiramate|Behavioral: Cognitive restructuring intervention University of Sao Paulo Phase 2 2015-01-01 2015-12-01
    NCT00167245 Alcoholism|Cocaine Dependence Drug: Topiramate|Drug: placebo Kyle Kampman|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|University of Pennsylvania Phase 2 2004-09-01 2014-08-21
    NCT00802412 Nicotine Dependence|Alcohol Dependence Drug: Topiramate|Drug: Placebo VA Office of Research and Development Phase 2 2009-01-01 2016-12-06
    NCT00223626 Cocaine-Related Disorders Drug: Topiramate Bankole Johnson|National Institute on Drug Abuse (NIDA)|University of Virginia Phase 2 2007-01-01 2012-04-17
    NCT02424318 Migraine Disorders Drug: Topiramate SMG-SNU Boramae Medical Center Phase 4 2008-12-01 2015-04-18

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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