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Diltiazem HCl

盐酸地尔硫卓,RG 83606 HCl,RG-83606 HCl,RG83606 HCl

Diltiazem HCl (Tiazac)是Benzothiazepine的一种衍生物,由于其抑制钙离子在膜的功能,因而具有舒张血管的作用。

目录号
EY0496
EY0496
纯度
99.61%
99.61%
规格
100 mg
500 mg
原价
230
390
售价
230
390
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Gunthorpe, M.J. and Lummis, S.C. 1999. J. Physiol. 519: 713-722.
    [2] Smirnov, S.V. and Aaronson, P.I. 1998. Eur. J. Pharmacol. 360: 81-90.
    [3] Yamakage, M. and Namiki, A. 2002. Can J Anaesth. 49: 151-164.
    [4] Catterall, W.A., et al. 2005. Pharmacol. Rev. 57: 411-425.

    分子式
    C22H27ClN2O4S
    分子量
    450.98
    CAS号
    33286-22-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    50 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00983372 Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein Drug: Colchicine|Drug: Diltiazem ER|Drug: Colchicine Mutual Pharmaceutical Company, Inc. Phase 1 2008-08-01 2009-10-12
    NCT02080780 CLARITHROMYCIN/DILTIAZEM [VA Drug Interaction] Drug: Clarithromycin XL|Drug: 2% Diltiazem Ventrus Biosciences, Inc|TKL Research, Inc. Phase 1 2013-09-01 2014-03-07
    NCT02025465 Atrial Fibrillation|Atrial Flutter Drug: Metoprolol|Drug: Diltiazem CAMC Health System Phase 4 2013-12-01 2016-01-28
    NCT01261156 Healthy Subjects Drug: E5555 100 mg and diltiazem|Drug: E5555 300 mg and diltiazem Eisai Inc. Phase 1 2010-10-01 2014-07-10
    NCT01816529 Diltiazem Skin Sensitivity. Drug: Diltiazem Hydrochloride 2% Cream|Drug: Vehicle Cream|Drug: 0.1% solution of sodium lauryl sulfate (SLS)|Drug: Saline (0.9%) Ventrus Biosciences, Inc Phase 1 2013-03-01 2013-08-19
    NCT01914926 Heart Rate and Rhythm Disorders Drug: Metoprolol|Drug: Diltiazem Antonios Likourezos|Maimonides Medical Center Phase 4 2009-06-01 2014-05-01
    NCT02801305 Digital Ulcer of Scleroderma Drug: Diltiazem Gel 2%|Drug: Nitroglycerin Ointment 2%|Drug: Vaseline Mohammad Ali Nazarinia|Shiraz University of Medical Sciences Phase 2 2016-06-01 2017-03-03
    NCT00834925 Atrial Fibrillation Drug: low dose diltiazem Seoul National University Hospital Phase 4 2009-08-01 2011-07-25
    NCT02947711 Healthy Subjects Drug: E2027|Drug: Diltiazem ER Eisai Co., Ltd.|Eisai Inc. Phase 1 2016-10-01 2017-03-06
    NCT02024919 Coronary Artery Ectasia Drug: intracoronary administration of diltiazem|Drug: intracoronary injection of 5 mL saline Ankara University 2012-06-01 2015-05-05
    NCT01645826 Idiopathic Pulmonary Arterial Hypertension|Primary Pulmonary Hypertension|Pulmonary Arterial Hypertension|Familial Primary Pulmonary Hypertension Drug: Diltiazem Hydrochloride|Drug: Sugar Pill University of South Florida 2012-07-01 2013-09-06
    NCT02938260 Atrial Fibrillation|Heart Failure Drug: Metoprolol vs Diltiazem RaeAnn Hirschy|Kimberly Ackerbauer, PharmD, BCPS, BCCCP|Gary Peksa, PharmD, BCPS|Joshua DeMott, PharmD, BCPS, BCCCP|Paul O'Donnell, PharmD, BCPS, BCCCP|Rush University Medical Center 2010-01-01 2016-10-20
    NCT00318201 Healthy Drug: Erythromycin|Drug: Diltiazem Indiana University School of Medicine|Indiana University Phase 4 2006-04-01 2012-04-05
    NCT00713011 Diabetic Nephropathies|Hypertension Drug: Adalat XL|Drug: Tiazac XC Bayer Phase 3 2008-11-01 2012-11-14
    NCT01217515 Chronic Anal Fissure Drug: Diltiazem hydrochloride 4% cream|Drug: Diltiazem hydrochloride 2% cream|Other: Placebo S.L.A. Pharma AG Phase 3 2010-10-01 2014-07-07
    NCT01852565 Atherosclerosis Drug: Darapladib|Drug: Diltiazem GlaxoSmithKline Phase 1 2013-05-01 2013-10-04
    NCT01771978 Ischaemia-reperfusion Injury Drug: Placebo|Drug: Diltiazem|Drug: Acetylcystein|Drug: diltiazem and acetylcystein University Hospital, Strasbourg, France Phase 3 2002-06-01 2013-01-16
    NCT01151345 Healthy Drug: TILACEM|Drug: ANGIOTROFIN Pfizer Phase 1 2010-06-01 2011-09-06
    NCT01211808 Atrial Fibrillation Drug: BMS-914832|Drug: Diltiazem Bristol-Myers Squibb|PRA Health Sciences Phase 1 2010-09-01 2011-02-01
    NCT02526888 Healthy Subjects Drug: ACT-541468|Drug: Diltiazem Actelion Phase 1 2015-09-01 2016-11-15
    NCT01549496 Hepatitis C|Hypertension Drug: Amlodipine|Drug: Diltiazem Ottawa Hospital Research Institute|Merck Sharp & Dohme Corp. Phase 1 2012-05-01 2015-01-07
    NCT01408524 Hypertension|Craniotomy Drug: Diltiazem|Drug: Labetalol Mahidol University Phase 1|Phase 2 2010-02-01 2014-03-31

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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