Diltiazem HCl (Tiazac)是Benzothiazepine的一种衍生物,由于其抑制钙离子在膜的功能,因而具有舒张血管的作用。
Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Gunthorpe, M.J. and Lummis, S.C. 1999. J. Physiol. 519: 713-722.
[2] Smirnov, S.V. and Aaronson, P.I. 1998. Eur. J. Pharmacol. 360: 81-90.
[3] Yamakage, M. and Namiki, A. 2002. Can J Anaesth. 49: 151-164.
[4] Catterall, W.A., et al. 2005. Pharmacol. Rev. 57: 411-425.
分子式 C22H27ClN2O4S |
分子量 450.98 |
CAS号 33286-22-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water 50 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT00983372 | Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein | Drug: Colchicine|Drug: Diltiazem ER|Drug: Colchicine | Mutual Pharmaceutical Company, Inc. | Phase 1 | 2008-08-01 | 2009-10-12 |
NCT02080780 | CLARITHROMYCIN/DILTIAZEM [VA Drug Interaction] | Drug: Clarithromycin XL|Drug: 2% Diltiazem | Ventrus Biosciences, Inc|TKL Research, Inc. | Phase 1 | 2013-09-01 | 2014-03-07 |
NCT02025465 | Atrial Fibrillation|Atrial Flutter | Drug: Metoprolol|Drug: Diltiazem | CAMC Health System | Phase 4 | 2013-12-01 | 2016-01-28 |
NCT01261156 | Healthy Subjects | Drug: E5555 100 mg and diltiazem|Drug: E5555 300 mg and diltiazem | Eisai Inc. | Phase 1 | 2010-10-01 | 2014-07-10 |
NCT01816529 | Diltiazem Skin Sensitivity. | Drug: Diltiazem Hydrochloride 2% Cream|Drug: Vehicle Cream|Drug: 0.1% solution of sodium lauryl sulfate (SLS)|Drug: Saline (0.9%) | Ventrus Biosciences, Inc | Phase 1 | 2013-03-01 | 2013-08-19 |
NCT01914926 | Heart Rate and Rhythm Disorders | Drug: Metoprolol|Drug: Diltiazem | Antonios Likourezos|Maimonides Medical Center | Phase 4 | 2009-06-01 | 2014-05-01 |
NCT02801305 | Digital Ulcer of Scleroderma | Drug: Diltiazem Gel 2%|Drug: Nitroglycerin Ointment 2%|Drug: Vaseline | Mohammad Ali Nazarinia|Shiraz University of Medical Sciences | Phase 2 | 2016-06-01 | 2017-03-03 |
NCT00834925 | Atrial Fibrillation | Drug: low dose diltiazem | Seoul National University Hospital | Phase 4 | 2009-08-01 | 2011-07-25 |
NCT02947711 | Healthy Subjects | Drug: E2027|Drug: Diltiazem ER | Eisai Co., Ltd.|Eisai Inc. | Phase 1 | 2016-10-01 | 2017-03-06 |
NCT02024919 | Coronary Artery Ectasia | Drug: intracoronary administration of diltiazem|Drug: intracoronary injection of 5 mL saline | Ankara University | 2012-06-01 | 2015-05-05 | |
NCT01645826 | Idiopathic Pulmonary Arterial Hypertension|Primary Pulmonary Hypertension|Pulmonary Arterial Hypertension|Familial Primary Pulmonary Hypertension | Drug: Diltiazem Hydrochloride|Drug: Sugar Pill | University of South Florida | 2012-07-01 | 2013-09-06 | |
NCT02938260 | Atrial Fibrillation|Heart Failure | Drug: Metoprolol vs Diltiazem | RaeAnn Hirschy|Kimberly Ackerbauer, PharmD, BCPS, BCCCP|Gary Peksa, PharmD, BCPS|Joshua DeMott, PharmD, BCPS, BCCCP|Paul O'Donnell, PharmD, BCPS, BCCCP|Rush University Medical Center | 2010-01-01 | 2016-10-20 | |
NCT00318201 | Healthy | Drug: Erythromycin|Drug: Diltiazem | Indiana University School of Medicine|Indiana University | Phase 4 | 2006-04-01 | 2012-04-05 |
NCT00713011 | Diabetic Nephropathies|Hypertension | Drug: Adalat XL|Drug: Tiazac XC | Bayer | Phase 3 | 2008-11-01 | 2012-11-14 |
NCT01217515 | Chronic Anal Fissure | Drug: Diltiazem hydrochloride 4% cream|Drug: Diltiazem hydrochloride 2% cream|Other: Placebo | S.L.A. Pharma AG | Phase 3 | 2010-10-01 | 2014-07-07 |
NCT01852565 | Atherosclerosis | Drug: Darapladib|Drug: Diltiazem | GlaxoSmithKline | Phase 1 | 2013-05-01 | 2013-10-04 |
NCT01771978 | Ischaemia-reperfusion Injury | Drug: Placebo|Drug: Diltiazem|Drug: Acetylcystein|Drug: diltiazem and acetylcystein | University Hospital, Strasbourg, France | Phase 3 | 2002-06-01 | 2013-01-16 |
NCT01151345 | Healthy | Drug: TILACEM|Drug: ANGIOTROFIN | Pfizer | Phase 1 | 2010-06-01 | 2011-09-06 |
NCT01211808 | Atrial Fibrillation | Drug: BMS-914832|Drug: Diltiazem | Bristol-Myers Squibb|PRA Health Sciences | Phase 1 | 2010-09-01 | 2011-02-01 |
NCT02526888 | Healthy Subjects | Drug: ACT-541468|Drug: Diltiazem | Actelion | Phase 1 | 2015-09-01 | 2016-11-15 |
NCT01549496 | Hepatitis C|Hypertension | Drug: Amlodipine|Drug: Diltiazem | Ottawa Hospital Research Institute|Merck Sharp & Dohme Corp. | Phase 1 | 2012-05-01 | 2015-01-07 |
NCT01408524 | Hypertension|Craniotomy | Drug: Diltiazem|Drug: Labetalol | Mahidol University | Phase 1|Phase 2 | 2010-02-01 | 2014-03-31 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们