Levosimendan是钙增敏剂,通过与cardiac troponin C (cTnC)结合而发挥作用。
Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.
0.03, 0.1, 0.3 μM缓冲液流线给药
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Haikala H, J Mol Cell Cardiol, 1995, 27(9), 1859-1866.
[2] Eriksson O, Pollesello P, Haikala H. J Cardiovasc Pharmacol. 44:316-21 (2004).
[3] Udvary E, Papp JG, Vegh A. Br J Pharmacol. 114:656-61 (1995)
[4] Parissis JT, Adamopoulos S, Antoniades C et al. Am J Cardiol. 93:1309-12 (2004)
分子式 C14H12N6O |
分子量 280.28 |
CAS号 141505-33-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT02972918 | Ventricular Dysfunction, Left|Hip Fracture | Drug: Levosimendan | Hospital Universitario de Canarias|Orion Corporation, Orion Pharma | 2014-05-01 | 2016-11-21 | |
NCT01969071 | Mitral Valve Stenosis With Incompetence or Regurgitation | Drug: Levosimendan|Drug: Dobutamine | Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital | Phase 4 | 2009-07-01 | 2013-10-23 |
NCT01120106 | Low Cardiac Output Syndrome | Drug: levosimendan|Drug: placebo | Bambino Ges霉 Hospital and Research Institute | Phase 2 | 2009-01-01 | 2012-06-22 |
NCT00988806 | Advanced Heart Failure | Drug: Levosimendan|Drug: Placebo | Hospital Universitario de Canarias | Phase 4 | 2009-11-01 | 2013-09-17 |
NCT01318460 | Coronary Artery Disease | Drug: Levosimendan infusion|Drug: Placebo infusion | AHEPA University Hospital|Orion Corporation, Orion Pharma | Phase 4 | 2011-03-01 | 2014-03-11 |
NCT03022877 | Myocardial Infarction|Outcome | Drug: Levosimendan | RWTH Aachen University | 2017-06-01 | 2017-01-12 | |
NCT01720030 | Acute Kidney Injury | Drug: Levosimendan|Drug: Conventional therapy | VieCuri Medical Centre|Orion Corporation, Orion Pharma | Phase 2|Phase 3 | 2016-09-01 | 2016-09-26 |
NCT01065194 | Chronic Stable Heart Failure | Drug: Levosimendan|Drug: Placebo | Medical University Innsbruck|Orion Corporation, Orion Pharma | Phase 3 | 2009-08-01 | 2010-08-27 |
NCT02531724 | Acute Kidney Injury|Renal Insufficiency, Acute | Drug: Levosimendan|Drug: Placebo | Sahlgrenska University Hospital, Sweden | Phase 4 | 2015-09-01 | 2016-06-15 |
NCT01536132 | Heart Failure | Drug: Levosimendan|Drug: Placebo | Parc de Salut Mar | Phase 4 | 2010-04-01 | 2016-02-13 |
NCT01221116 | Heart Failure|Cardiac Surgery | Drug: levosimendan | Ullevaal University Hospital | 2003-01-01 | 2010-11-01 | |
NCT01721434 | Muscle Weakness Conditions|Weaning Failure | Drug: Levosimendan|Drug: Placebo | University Medical Center Nijmegen|Orion Corporation, Orion Pharma | Phase 2|Phase 3 | 2012-09-01 | 2015-06-09 |
NCT01290146 | Advanced Chronic Heart Failure | Drug: Diuretics|Drug: Levosimendan | Niguarda Hospital|Orion Corporation, Orion Pharma | Phase 3 | 2011-02-01 | 2016-01-16 |
NCT01210976 | Heart Valve Disease | Drug: levosimendan|Drug: placebo | Tampere University Hospital | Phase 4 | 2009-01-01 | 2011-09-20 |
NCT00154115 | Heart Failure | Drug: levosimendan|Drug: placebo | Kuopio University Hospital | Phase 4 | 2005-03-01 | 2009-01-20 |
NCT02640846 | Septic Shock|Cardiomyopathy | Drug: Levosimendan|Drug: Milrinone | Sahlgrenska University Hospital, Sweden | Phase 4 | 2015-12-01 | 2016-02-02 |
NCT01301313 | Acute Heart Failure | Drug: Levosimendan|Drug: Conventional intensified inotropic treatment | Jose Luis Vazquez Martinez|Hospital Universitario Ramon y Cajal | Phase 2 | 2011-02-01 | 2013-01-30 |
NCT02133105 | Cardiorenal Syndrome | Drug: Levosimendan|Drug: Dobutamine | G枚teborg University|Sahlgrenska University Hospital, Sweden | Phase 3 | 2014-04-01 | 2017-02-01 |
NCT00994825 | Low Cardiac Output Syndrome | Drug: Levosimendan|Drug: placebo | Universit脿 Vita-Salute San Raffaele | Phase 4 | 2009-11-01 | 2016-07-21 |
NCT02025621 | Coronary Artery Bypass Grafting|Mitral Valve Surgery|Low Cardiac Output Syndrome | Drug: Levosimendan|Drug: Placebo | Tenax Therapeutics, Inc. | Phase 3 | 2014-07-01 | 2016-11-18 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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