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Levosimendan

左西孟旦,Simdax,OR-1259,OR 1259,OR1259,

Levosimendan是钙增敏剂,通过与cardiac troponin C (cTnC)结合而发挥作用。

目录号
EY0487
EY0487
EY0487
纯度
99.31%
99.31%
99.31%
规格
50 mg
100 mg
500 mg
原价
380
685
2600
售价
380
685
2600
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    0.03, 0.1, 0.3 μM缓冲液流线给药

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Haikala H, J Mol Cell Cardiol, 1995, 27(9), 1859-1866.
    [2] Eriksson O, Pollesello P, Haikala H. J Cardiovasc Pharmacol. 44:316-21 (2004).
    [3] Udvary E, Papp JG, Vegh A. Br J Pharmacol. 114:656-61 (1995)
    [4] Parissis JT, Adamopoulos S, Antoniades C et al. Am J Cardiol. 93:1309-12 (2004)

    分子式
    C14H12N6O
    分子量
    280.28
    CAS号
    141505-33-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02972918 Ventricular Dysfunction, Left|Hip Fracture Drug: Levosimendan Hospital Universitario de Canarias|Orion Corporation, Orion Pharma 2014-05-01 2016-11-21
    NCT01969071 Mitral Valve Stenosis With Incompetence or Regurgitation Drug: Levosimendan|Drug: Dobutamine Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital Phase 4 2009-07-01 2013-10-23
    NCT01120106 Low Cardiac Output Syndrome Drug: levosimendan|Drug: placebo Bambino Ges霉 Hospital and Research Institute Phase 2 2009-01-01 2012-06-22
    NCT00988806 Advanced Heart Failure Drug: Levosimendan|Drug: Placebo Hospital Universitario de Canarias Phase 4 2009-11-01 2013-09-17
    NCT01318460 Coronary Artery Disease Drug: Levosimendan infusion|Drug: Placebo infusion AHEPA University Hospital|Orion Corporation, Orion Pharma Phase 4 2011-03-01 2014-03-11
    NCT03022877 Myocardial Infarction|Outcome Drug: Levosimendan RWTH Aachen University 2017-06-01 2017-01-12
    NCT01720030 Acute Kidney Injury Drug: Levosimendan|Drug: Conventional therapy VieCuri Medical Centre|Orion Corporation, Orion Pharma Phase 2|Phase 3 2016-09-01 2016-09-26
    NCT01065194 Chronic Stable Heart Failure Drug: Levosimendan|Drug: Placebo Medical University Innsbruck|Orion Corporation, Orion Pharma Phase 3 2009-08-01 2010-08-27
    NCT02531724 Acute Kidney Injury|Renal Insufficiency, Acute Drug: Levosimendan|Drug: Placebo Sahlgrenska University Hospital, Sweden Phase 4 2015-09-01 2016-06-15
    NCT01536132 Heart Failure Drug: Levosimendan|Drug: Placebo Parc de Salut Mar Phase 4 2010-04-01 2016-02-13
    NCT01221116 Heart Failure|Cardiac Surgery Drug: levosimendan Ullevaal University Hospital 2003-01-01 2010-11-01
    NCT01721434 Muscle Weakness Conditions|Weaning Failure Drug: Levosimendan|Drug: Placebo University Medical Center Nijmegen|Orion Corporation, Orion Pharma Phase 2|Phase 3 2012-09-01 2015-06-09
    NCT01290146 Advanced Chronic Heart Failure Drug: Diuretics|Drug: Levosimendan Niguarda Hospital|Orion Corporation, Orion Pharma Phase 3 2011-02-01 2016-01-16
    NCT01210976 Heart Valve Disease Drug: levosimendan|Drug: placebo Tampere University Hospital Phase 4 2009-01-01 2011-09-20
    NCT00154115 Heart Failure Drug: levosimendan|Drug: placebo Kuopio University Hospital Phase 4 2005-03-01 2009-01-20
    NCT02640846 Septic Shock|Cardiomyopathy Drug: Levosimendan|Drug: Milrinone Sahlgrenska University Hospital, Sweden Phase 4 2015-12-01 2016-02-02
    NCT01301313 Acute Heart Failure Drug: Levosimendan|Drug: Conventional intensified inotropic treatment Jose Luis Vazquez Martinez|Hospital Universitario Ramon y Cajal Phase 2 2011-02-01 2013-01-30
    NCT02133105 Cardiorenal Syndrome Drug: Levosimendan|Drug: Dobutamine G枚teborg University|Sahlgrenska University Hospital, Sweden Phase 3 2014-04-01 2017-02-01
    NCT00994825 Low Cardiac Output Syndrome Drug: Levosimendan|Drug: placebo Universit脿 Vita-Salute San Raffaele Phase 4 2009-11-01 2016-07-21
    NCT02025621 Coronary Artery Bypass Grafting|Mitral Valve Surgery|Low Cardiac Output Syndrome Drug: Levosimendan|Drug: Placebo Tenax Therapeutics, Inc. Phase 3 2014-07-01 2016-11-18

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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