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Valdecoxib

伐地考昔

Valdecoxib是一种强有效和选择性的COX-2抑制剂，IC50为5nM.

目录号
EY0480
EY0480
EY0480
纯度
99.57%
99.57%
99.57%
规格
5 mg
10 mg
50 mg
原价
480
785
3200
售价
480
785
3200
库存
现货
现货
现货
订购
订购
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  • 生物活性

    Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    10.2mg/kg 口服

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Talley JJ, et al. J Med Chem, 2000, 43(5), 775-777.
    [2] Roumie, Christianne L. Stroke (2008), 39(7), 2037-2045.
    [3] Gierse JK, et al. Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J Pharmacol Exp Ther. 2005 Mar;312(3):1206-12.

    分子式
    C16H14N2O3S    		 分子量
    314.36    		 CAS号
    181695-72-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    63 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    18 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00650455 Arthritis, Rheumatoid Drug: valdecoxib|Drug: naproxen|Drug: placebo Pfizer Phase 4 2003-02-01 2008-07-18
    NCT00419549 ERCP|Pancreatitis Drug: Glyceryl - trinitrate|Drug: Valdecoxib All India Institute of Medical Sciences, New Delhi Phase 2|Phase 3 2003-10-01 2009-01-28
    NCT00021996 Pain|Unspecified Adult Solid Tumor, Protocol Specific Drug: valdecoxib Dana-Farber Cancer Institute|National Cancer Institute (NCI) 2001-01-01 2013-07-17
    NCT00660855 Pain, Post Surgical Drug: parecoxib/valdecoxib Pfizer Phase 4 2004-06-01 2008-04-21
    NCT00649610 Low Back Pain Drug: valdecoxib|Drug: diclofenac Pfizer Phase 4 2002-11-01 2008-04-07
    NCT00260325 Pain|Hyperalgesia Drug: valdecoxib Penn State University|Pfizer|National Institutes of Health (NIH) Phase 4 2004-08-01 2007-05-29
    NCT00652808 Osteoarthritis|Knee Drug: valdecoxib|Drug: naproxen Pfizer Phase 3 2004-05-01 2008-04-07
    NCT00671320 Pain|Sprains and Strains|Sprain Drug: valdecoxib|Drug: diclofenac Pfizer Phase 4 2002-12-01 2008-04-30
    NCT00683137 Pain|Hallux Valgus Drug: valdecoxib|Drug: valdecoxib|Drug: valdecoxib/placebo Pfizer Phase 3 2002-10-01 2008-05-22
    NCT00661635 Laparoscopic Cholecystectomy|Pain Drug: placebo|Drug: valdecoxib|Drug: valdecoxib Pfizer Phase 3 2002-11-01 2008-04-21
    NCT00657449 Acute Pain Drug: valdecoxib|Drug: rofecoxib Pfizer Phase 4 2003-06-01 2008-04-08
    NCT00653354 Pain, Post-Surgical Drug: valdecoxib|Drug: valdecoxib/placebo|Drug: placebo Pfizer Phase 3 2002-12-01 2008-04-07
    NCT00648258 Osteoarthritis Drug: valdecoxib|Drug: naproxen Pfizer Phase 3 2003-07-01 2008-04-07
    NCT00647829 Pharyngitis Drug: valdecoxib|Drug: valdecoxib|Drug: placebo Pfizer Phase 3 2003-02-01 2008-04-23
    NCT00649415 Dysmenorrhea Drug: piroxicam|Drug: valdecoxib Pfizer Phase 4 2003-01-01 2008-04-07
    NCT00650039 Pain Drug: placebo|Drug: valdecoxib|Drug: valdecoxib Pfizer Phase 3 2004-03-01 2008-06-03
    NCT00650598 Pain, Postoperative Drug: valdecoxib|Drug: diclofenac Pfizer Phase 4 2004-03-01 2008-10-06
    NCT00650624 Osteoarthritis, Knee Drug: valdecoxib|Drug: valdecoxib|Drug: valdecoxib|Drug: placebo Pfizer Phase 2 2003-06-01 2008-04-07
    NCT00636064 Pain Drug: Parecoxib Sodium/Valdecoxib|Drug: Placebo/Valdecoxib|Other: Placebo/Placebo Pfizer Phase 3 2003-01-01 2008-10-09
    NCT00122096 Neurosurgery|Pain Drug: valdecoxib University of Washington|Pfizer Phase 4 2002-11-01 2008-09-25
    NCT00651300 Pain Drug: Parecoxib/Valdecoxib|Drug: Placebo Pfizer Phase 3 2003-04-01 2009-06-08
    NCT00092300 Postoperative Pain Drug: MK0966, rofecoxib|Drug: Comparator: valdecoxib Merck Sharp & Dohme Corp. Phase 3 2002-05-01 2015-07-31
    NCT00092339 Postoperative Pain Drug: MK0966, rofecoxib|Drug: Comparator: valdecoxib, placebo Merck Sharp & Dohme Corp. Phase 3 2002-08-01 2015-09-15
    NCT01541137 Postoperative Pain Drug: Diclofenac|Drug: parecoxib/ valdecoxib|Device: patient controlled epidural analgesia Helsinki University Central Hospital|Academy of Finland 2004-03-01 2012-02-28
    NCT01361789 Rupture of Anterior Cruciate Ligament Drug: parecoxib, valdecoxib, etoricoxib|Drug: Dexamethasone|Drug: parecoxib, valdecoxib, parecoxib and dexamethasone Asker & Baerum Hospital Phase 4 2004-01-01 2011-05-26

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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