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Primaquine Diphosphate

磷酸伯安喹,Primaquine phosphate,Primaquine bisphosphate

Primaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药,对人类疟疾的的配子体抵抗活性较强。

目录号
EY0479
EY0479
EY0479
纯度
99.47%
99.47%
99.47%
规格
500 mg
1 g
5 g
原价
470
775
990
售价
470
775
990
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Vale N, et al. Eur J Med Chem, 2009, 44(3), 937-953.
    [2] Orta-Salazar G, Bouchard RA, Morales-Salgado F et al. Br J Pharmacol. 135 :751-63 (2002).
    [3] Chatterjee T, Muhkopadhyay A, Khan KA, Giri AK. Mutagenesis. 13:619-24 (1998).

    分子式
    C15H27N3O9P2
    分子量
    455.34
    CAS号
    63-45-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    90 mg/mL
    Water
    90 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01780753 Vivax Malaria Drug: Primaquine University of Oxford Phase 1 2012-12-01 2016-02-12
    NCT02898779 Malaria Drug: Primaquine, R-Primaquine, S-Primaquine, SR Primaquine University of Mississippi, Oxford Phase 1 2017-02-01 2017-02-10
    NCT02789566 Obese Drug: Primaquine University of Oxford Phase 1 2011-08-01 2016-06-01
    NCT02535767 Malaria Drug: Primaquine University of California, San Francisco|Malaria Research and Training Center, Bamako, Mali|Radboud University|University of Mississippi Medical Center|Bill and Melinda Gates Foundation Phase 1|Phase 2 2015-08-01 2017-02-02
    NCT01365598 Falciparum Malaria Drug: Primaquine London School of Hygiene and Tropical Medicine|Wellcome Trust Phase 3 2011-12-01 2013-06-11
    NCT02364583 Plasmodium Vivax Drug: Primaquine Papua New Guinea Institute of Medical Research|Walter and Eliza Hall Institute of Medical Research|The University of Western Australia|University of Oxford|Curtin University Phase 4 2010-06-01 2015-10-12
    NCT01668433 G6PD Normal|G6PD Deficient|Healthy Drug: Regimens (Primaquine, Methylene blue) University of Oxford Phase 1 2013-07-01 2015-11-02
    NCT02793388 Malaria Drug: Supervised primaquine treatment|Drug: Unsupervised primaquine treatment Menzies School of Health Research|Armauer Hansen Research Institute, Ethiopia Phase 4 2016-09-01 2017-02-07
    NCT01552330 Healthy Drug: Primaquine and Pyronaridine-artesunate|Drug: Primaquine and Pyronaridine-Artesunate University of Oxford Phase 1 2012-05-01 2013-08-27
    NCT01716260 Vivax Malaria Drug: Chloroquine|Drug: Primaquine Menzies School of Health Research|Ministry of Health, Bhutan 2013-01-01 2016-05-26
    NCT02960568 Pharmacologic Action Drug: Primaquine Walter Reed Army Institute of Research (WRAIR) Phase 1 2016-01-01 2016-11-08
    NCT02691910 Malaria, Vivax Drug: Chloroquine|Drug: Primaquine Oswaldo Cruz Foundation|University of Sao Paulo Phase 2|Phase 3 2014-08-01 2016-02-24
    NCT01849640 Uncomplicated Plasmodium Falciparum Malaria Drug: DHA-piperaquine and Primaquine David Saunders|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Royal Cambodian Armed Forces|US Department of Defense Armed Forces Health Surveillance Center|Armed Forces Research Institute of Medical Sciences, Thailand 2012-12-01 2015-07-13
    NCT02090036 Plasmodium Falciparum Drug: Primaquine (For artemether-lumefantrine+primaquine arm)|Drug: Placebo (For artemether-lumefantrine arm) Muhimbili University of Health and Allied Sciences|Karolinska Institutet Phase 4 2014-07-01 2014-12-05
    NCT02434952 Malaria, Falciparum|G6PD Deficiency Drug: Dihydroartemisinin piperaquine (DHA PP)|Drug: Primaquine Malaria Consortium|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Institute Pasteur, Cambodia|World Health Organization|Centers for Disease Control and Prevention Phase 4 2014-10-01 2016-08-22
    NCT01525511 Healthy Drug: A|Drug: B University of Oxford Phase 1 2012-06-01 2013-08-27
    NCT01288820 Vivax Malaria Drug: Dihydroartemisinin/piperaquine + primaquine|Drug: Artesunate-amodiaquine + primaquine University of Oxford|Mahidol University|Ministry of Health, Indonesia Phase 3 2011-01-01 2013-08-28
    NCT01935882 Malaria|Asymptomatic Malaria|Plasmodium Falciparum Drug: Artemether-lumefantrine combination|Drug: Artemether-Lumefantrine with a single dose of 0.25mg/kg primaquine|Drug: Artemether-Lumefantrine with a single dose of 0.4mg/kg primaquine London School of Hygiene and Tropical Medicine|Radboud University|Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso Phase 2|Phase 3 2013-09-01 2015-09-01
    NCT01837992 Malaria Drug: Primaquine|Drug: delayed primaquine Menzies School of Health Research|Walter and Eliza Hall Institute of Medical Research|Ministry of Health, Vanuatu|Ministry of Health, Solomon Islands|World Health Organization 2013-05-01 2013-11-07
    NCT00158587 Malaria|Vivax Malaria Drug: primaquine London School of Hygiene and Tropical Medicine|HealthNet TPO Phase 3 2004-04-01 2017-01-11
    NCT02876549 Vivax Malaria Drug: Chloroquine|Drug: Primaquine 0.25 mg/kg/day|Drug: Primaquine 0.75 mg/kg weekly University of Oxford|Mahidol Oxford Tropical Medicine Research Unit|Nangarhar University, Afghanistan Phase 4 2016-08-01 2016-08-22

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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