Primaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药,对人类疟疾的的配子体抵抗活性较强。
Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Vale N, et al. Eur J Med Chem, 2009, 44(3), 937-953.
[2] Orta-Salazar G, Bouchard RA, Morales-Salgado F et al. Br J Pharmacol. 135 :751-63 (2002).
[3] Chatterjee T, Muhkopadhyay A, Khan KA, Giri AK. Mutagenesis. 13:619-24 (1998).
分子式 C15H27N3O9P2 |
分子量 455.34 |
CAS号 63-45-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 90 mg/mL |
Water 90 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT01780753 | Vivax Malaria | Drug: Primaquine | University of Oxford | Phase 1 | 2012-12-01 | 2016-02-12 |
NCT02898779 | Malaria | Drug: Primaquine, R-Primaquine, S-Primaquine, SR Primaquine | University of Mississippi, Oxford | Phase 1 | 2017-02-01 | 2017-02-10 |
NCT02789566 | Obese | Drug: Primaquine | University of Oxford | Phase 1 | 2011-08-01 | 2016-06-01 |
NCT02535767 | Malaria | Drug: Primaquine | University of California, San Francisco|Malaria Research and Training Center, Bamako, Mali|Radboud University|University of Mississippi Medical Center|Bill and Melinda Gates Foundation | Phase 1|Phase 2 | 2015-08-01 | 2017-02-02 |
NCT01365598 | Falciparum Malaria | Drug: Primaquine | London School of Hygiene and Tropical Medicine|Wellcome Trust | Phase 3 | 2011-12-01 | 2013-06-11 |
NCT02364583 | Plasmodium Vivax | Drug: Primaquine | Papua New Guinea Institute of Medical Research|Walter and Eliza Hall Institute of Medical Research|The University of Western Australia|University of Oxford|Curtin University | Phase 4 | 2010-06-01 | 2015-10-12 |
NCT01668433 | G6PD Normal|G6PD Deficient|Healthy | Drug: Regimens (Primaquine, Methylene blue) | University of Oxford | Phase 1 | 2013-07-01 | 2015-11-02 |
NCT02793388 | Malaria | Drug: Supervised primaquine treatment|Drug: Unsupervised primaquine treatment | Menzies School of Health Research|Armauer Hansen Research Institute, Ethiopia | Phase 4 | 2016-09-01 | 2017-02-07 |
NCT01552330 | Healthy | Drug: Primaquine and Pyronaridine-artesunate|Drug: Primaquine and Pyronaridine-Artesunate | University of Oxford | Phase 1 | 2012-05-01 | 2013-08-27 |
NCT01716260 | Vivax Malaria | Drug: Chloroquine|Drug: Primaquine | Menzies School of Health Research|Ministry of Health, Bhutan | 2013-01-01 | 2016-05-26 | |
NCT02960568 | Pharmacologic Action | Drug: Primaquine | Walter Reed Army Institute of Research (WRAIR) | Phase 1 | 2016-01-01 | 2016-11-08 |
NCT02691910 | Malaria, Vivax | Drug: Chloroquine|Drug: Primaquine | Oswaldo Cruz Foundation|University of Sao Paulo | Phase 2|Phase 3 | 2014-08-01 | 2016-02-24 |
NCT01849640 | Uncomplicated Plasmodium Falciparum Malaria | Drug: DHA-piperaquine and Primaquine | David Saunders|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Royal Cambodian Armed Forces|US Department of Defense Armed Forces Health Surveillance Center|Armed Forces Research Institute of Medical Sciences, Thailand | 2012-12-01 | 2015-07-13 | |
NCT02090036 | Plasmodium Falciparum | Drug: Primaquine (For artemether-lumefantrine+primaquine arm)|Drug: Placebo (For artemether-lumefantrine arm) | Muhimbili University of Health and Allied Sciences|Karolinska Institutet | Phase 4 | 2014-07-01 | 2014-12-05 |
NCT02434952 | Malaria, Falciparum|G6PD Deficiency | Drug: Dihydroartemisinin piperaquine (DHA PP)|Drug: Primaquine | Malaria Consortium|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Institute Pasteur, Cambodia|World Health Organization|Centers for Disease Control and Prevention | Phase 4 | 2014-10-01 | 2016-08-22 |
NCT01525511 | Healthy | Drug: A|Drug: B | University of Oxford | Phase 1 | 2012-06-01 | 2013-08-27 |
NCT01288820 | Vivax Malaria | Drug: Dihydroartemisinin/piperaquine + primaquine|Drug: Artesunate-amodiaquine + primaquine | University of Oxford|Mahidol University|Ministry of Health, Indonesia | Phase 3 | 2011-01-01 | 2013-08-28 |
NCT01935882 | Malaria|Asymptomatic Malaria|Plasmodium Falciparum | Drug: Artemether-lumefantrine combination|Drug: Artemether-Lumefantrine with a single dose of 0.25mg/kg primaquine|Drug: Artemether-Lumefantrine with a single dose of 0.4mg/kg primaquine | London School of Hygiene and Tropical Medicine|Radboud University|Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso | Phase 2|Phase 3 | 2013-09-01 | 2015-09-01 |
NCT01837992 | Malaria | Drug: Primaquine|Drug: delayed primaquine | Menzies School of Health Research|Walter and Eliza Hall Institute of Medical Research|Ministry of Health, Vanuatu|Ministry of Health, Solomon Islands|World Health Organization | 2013-05-01 | 2013-11-07 | |
NCT00158587 | Malaria|Vivax Malaria | Drug: primaquine | London School of Hygiene and Tropical Medicine|HealthNet TPO | Phase 3 | 2004-04-01 | 2017-01-11 |
NCT02876549 | Vivax Malaria | Drug: Chloroquine|Drug: Primaquine 0.25 mg/kg/day|Drug: Primaquine 0.75 mg/kg weekly | University of Oxford|Mahidol Oxford Tropical Medicine Research Unit|Nangarhar University, Afghanistan | Phase 4 | 2016-08-01 | 2016-08-22 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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