Miglitol是口服的抗糖尿病化合物,能抑制糖复合体分解为葡萄糖。
Miglitol is an oral anti-diabetic drug.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Lembcke, B., et al.: Digestion, 31, 120 (1985)
[2] Yoshikuni, Y., et al.: J. Pharmacobio-Dyn., 11, 356 (1988)
分子式 C8H17NO5 |
分子量 207.22 |
CAS号 72432-03-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 3 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT01099839 | Healthy Volunteers|Pharmacokinetics of ASP1941 | Drug: ASP1941|Drug: Miglitol | Astellas Pharma Inc | Phase 1 | 2010-02-01 | 2010-06-08 |
NCT00213122 | Type 2 Diabetes Mellitus | Drug: miglitol | Sanwa Kagaku Kenkyusho Co., Ltd. | Phase 3 | null | 2006-09-25 |
NCT00380822 | Type 2 Diabetes Mellitus | Drug: miglitol | Sanwa Kagaku Kenkyusho Co., Ltd. | Phase 3 | null | 2006-09-25 |
NCT00213109 | Type 1 Diabetes Mellitus | Drug: Miglitol | Sanwa Kagaku Kenkyusho Co., Ltd. | Phase 3 | null | 2006-09-20 |
NCT00334503 | Type 2 Diabetes Mellitus | Drug: Miglitol | Sanwa Kagaku Kenkyusho Co., Ltd. | Phase 3 | null | 2008-10-08 |
NCT00213070 | Type 2 Diabetes Mellitus | Drug: Miglitol | Sanwa Kagaku Kenkyusho Co., Ltd. | Phase 3 | null | 2006-09-20 |
NCT00334399 | Type 2 Diabetes Mellitus | Drug: Miglitol | Sanwa Kagaku Kenkyusho Co., Ltd. | Phase 3 | null | 2008-10-08 |
NCT01242202 | Type 2 Diabetes Mellitus | Drug: ASP1941|Drug: alpha glucosidase inhibitor | Astellas Pharma Inc | Phase 3 | 2010-10-01 | 2016-01-18 |
NCT02669693 | Diabetes | Dietary Supplement: bread without olives|Dietary Supplement: bread with olives | University of Leeds | 2015-12-01 | 2017-03-22 | |
NCT01697592 | Type 2 Diabetes Mellitus | Drug: Omarigliptin|Drug: Matching placebo to omarigliptin | Merck Sharp & Dohme Corp. | Phase 3 | 2012-10-01 | 2016-10-28 |
NCT02475499 | Diabetes Mellitus, Type 2 | Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Sulfonylureas|Drug: Biguanides|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2014-03-01 | 2016-03-11 | |
NCT02476760 | Diabetes Mellitus, Type 2 | Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Insulins|Drug: Biguanides|Drug: Sulfonylureas|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2014-03-01 | 2016-11-01 | |
NCT02456428 | Type 2 Diabetes Mellitus | Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Insulins|Drug: Biguanides|Drug: Sulfonylureas|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2014-03-01 | 2016-04-15 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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