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Valsartan

缬沙坦,CGP-48933,CGP48933,CGP 48933,

Valsartan是一种血管紧张素II受体拮抗剂,IC50在39.5到116 μM之间。

目录号
EY0469
EY0469
EY0469
纯度
99.20%
99.20%
99.20%
规格
1 mg
5 mg
100 mg
原价
110
260
2100
售价
110
260
2100
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Valsartan is a nonpeptide AT1 (angiotensin II AT1-receptor) antagonist with an IC50 ranging from 39.5 to 116 μM. This in turn causes blood vessel dilation. Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993)
    [2] Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)

    分子式
    C24H29N5O3
    分子量
    435.52
    CAS号
    137862-53-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    87 mg/mL
    Water
    <1 mg/mL
    Ethanol
    87 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01912534 Hypertrophic Cardiomyopathy Drug: Valsartan|Drug: Placebo New England Research Institutes|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2014-04-01 2016-05-16
    NCT00446524 Hypertension Drug: Valsartan + Amlodipine besilate Novartis Phase 3 2007-02-01 2012-05-06
    NCT01115972 Healthy|Pharmacokinetics of Valsartan Drug: ASP1585|Drug: valsartan Astellas Pharma Inc Phase 1 2010-03-01 2010-05-26
    NCT00208767 Carotid Artery Diseases|Atherosclerosis Drug: Valsartan|Drug: Placebo Emory University Phase 2 2005-02-01 2015-11-09
    NCT01425411 Hypertension|Left Ventricular Hypertrophy Drug: valsartan Mustafa Kemal University|Novartis Pharmaceuticals Phase 4 2006-11-01 2011-08-29
    NCT02631031 Healthy Normotensive Volunteers Drug: Valsartan Ain Shams University Phase 1 2015-11-01 2016-07-11
    NCT00140790 Hypertension Drug: valsartan Kumamoto University Phase 4 2006-08-01 2016-02-25
    NCT01070043 Hypertension|High Blood Pressure Drug: Amlodipine 5mg/Valsartan 80 mg|Drug: Valsartan Novartis Phase 4 2009-06-01 2011-09-13
    NCT00657241 Hypertension Drug: carvedilol|Drug: valsartan State University of New York at Buffalo|GlaxoSmithKline Phase 3 2008-04-01 2010-06-30
    NCT02690974 Hearth Failure With Reduced Ejection Fraction (HFrEF) Drug: LCZ696 (sacubitril/valsartan) Novartis Pharmaceuticals|Novartis Phase 4 2016-03-09 2017-02-28
    NCT00149227 Hypertension|Ischemic Heart Disease|Congestive Heart Failure|Stroke Drug: Valsartan|Drug: Non-ARB Kyoto Prefectural University of Medicine Phase 4 2004-01-01 2012-12-09
    NCT02815657 Type 2 Diabetes Drug: SP2086|Drug: Valsartan Jiangsu HengRui Medicine Co., Ltd. Phase 1 2013-04-01 2016-06-23
    NCT01541189 Hypertension Drug: Valsartan Novartis Pharmaceuticals|Novartis Phase 4 2012-02-01 2017-03-17
    NCT01805804 First Time Dual Chamber Pacemaker Implantation Drug: placebo/valsartan Medical University of Silesia|Polpharma Pharmaceutical Company Phase 4 2017-01-01 2017-01-01
    NCT01681576 Salt-sensitive Hypertension Drug: Valsartan|Drug: LCZ696 Novartis Pharmaceuticals|Novartis Phase 2 2012-08-01 2015-10-12
    NCT02916160 Chronic Heart Failure|Sleep Apnea Syndrome Drug: SACUBITRIL - VALSARTAN (formerly LCZ696, ENTRESTO庐) University Hospital, Montpellier 2016-09-01 2016-09-23
    NCT00809926 Stage 2 Hypertension Drug: Valsartan/aliskiren|Drug: Valsartan Novartis Phase 4 2009-01-01 2011-03-31
    NCT01095822 Diabetes Mellitus Drug: Aliskiren + Valsartan HeartDrug Research LLC|Novartis Phase 4 2010-03-01 2010-03-29
    NCT00457626 Hypertension Drug: Valsartan Novartis Pharmaceuticals|Novartis Phase 3 2007-04-01 2016-11-16
    NCT01001572 Essential Hypertension Drug: Valsartan/amlodipine 160/5 mg|Drug: Valsartan 160 mg|Drug: Placebo Novartis Phase 3 2009-09-01 2011-05-18
    NCT01850160 Hypertension Drug: GROUP A: Valsartan plus Chlorthalidone|Drug: GROUP B: Valsartan|Drug: GROUP C: Chlorthalidone Farma de Colombia SA Phase 3 2013-04-01 2016-01-25
    NCT00416468 Healthy Drug: Aliskiren|Drug: Valsartan Novartis Phase 1 2006-11-01 2007-06-21
    NCT00416728 Healthy Drug: Aliskiren|Drug: Valsartan Novartis Phase 1 2006-11-01 2007-06-21
    NCT00415883 Healthy Drug: Valsartan Novartis Phase 1 2006-07-01 2007-06-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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