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Quercetin

槲皮黄酮,栎精,橡黄素,Sophoretin,Meletin

槲皮素是一具抗癌活性的类黄酮。

目录号
EY0461
EY0461
纯度
99.20%
99.20%
规格
100 mg
500 mg
原价
120
380
售价
120
380
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Navarro-Nunez L, et al. Fitoterapia, 2010, 81(2):75-80.
    [2] Tiong, K.H., et al. 2010. Xenobiotica. 40: 458-466.
    [3] Li, B.H. and Tian, W.X. 2003. J Enzyme Inhib Med Chem. 18: 349-356.
    [4] Lupu, R. and Menendez, J.A. 2006. Curr Pharm Biotechnol. 7: 483-493.

    分子式
    C15H10O7
    分子量
    302.24
    CAS号
    117-39-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    <1 mg/mL
    Ethanol
    2 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01708278 Chronic Obstructive Pulmonary Disease Drug: Quercetin|Other: Placebo - sugar chew University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) Phase 1 2014-02-01 2016-10-31
    NCT01376011 Stroke|Problem of Aging Dietary Supplement: quercetin/placebo Brigham and Women's Hospital|National Institute on Aging (NIA) Early Phase 1 2009-06-01 2015-01-26
    NCT01720147 Fanconi Anemia Drug: Quercetin (dietary supplement) Children's Hospital Medical Center, Cincinnati Phase 1 2012-07-01 2016-08-19
    NCT02226484 Gastroesophageal Reflux Disease|GERD|Acid Reflux|Reflux Drug: Quercetin University of North Carolina, Chapel Hill|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 1 2014-08-01 2016-12-19
    NCT01438320 Chronic Hepatitis C Dietary Supplement: Quercetin University of California, Los Angeles|American Association for Cancer Research|Tower Cancer Research Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 1 2011-07-01 2015-03-18
    NCT00402623 Sarcoidosis Dietary Supplement: quercetin|Other: placebo Maastricht University Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development 2006-01-01 2017-02-22
    NCT01691404 Hypertension|Endothelial Dysfunction Dietary Supplement: Epicatechin|Dietary Supplement: Quercetin|Dietary Supplement: Placebo Wageningen University|Top Institute Food and Nutrition 2012-09-01 2013-04-22
    NCT01732393 Chemotherapy Induced Oral Mucositis Drug: oral quercetin capsules|Drug: Placebo Mashhad University of Medical Sciences Phase 1|Phase 2 2010-01-01 2012-12-04
    NCT01168739 Heat Acclimation and Thermotolerance Dietary Supplement: Quercetin|Dietary Supplement: Placebo University of New Mexico|Gatorade Sports and Science Institute|Quercegen Pharmaceuticals|Nash Finch Company 2009-09-01 2010-07-21
    NCT01912820 Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer Dietary Supplement: green tea extract|Drug: quercetin|Other: placebo|Procedure: therapeutic conventional surgery|Other: laboratory biomarker analysis Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) Phase 1 2014-01-01 2016-09-12
    NCT01722669 Healthy Drug: isoquercetin or quercetin Beth Israel Deaconess Medical Center Early Phase 1 2012-05-01 2017-03-02
    NCT01839344 Diabetes Mellitus, Type 2 Dietary Supplement: Quercetin|Drug: Acarbose|Drug: placebo Bastyr University Phase 2 2013-05-01 2015-03-16
    NCT01375101 Atrophic Oral Lichen Planus|Erosive Oral Lichen Planus Drug: placebo|Drug: Quercetin Mashhad University of Medical Sciences Phase 1 2010-04-01 2011-07-25
    NCT01538316 Primary Prevention of Prostate Cancer Dietary Supplement: Quercetin supplement|Dietary Supplement: Genistein supplement|Dietary Supplement: Placebo University of Hohenheim|University Hospital Tuebingen|Quercegen Pharmaceuticals 2012-03-01 2012-05-13
    NCT02989129 Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain Behavioral: Questionnaires|Drug: Quercetin M.D. Anderson Cancer Center Early Phase 1 2017-03-01 2016-12-12
    NCT00065676 Diabetes Mellitus|Obesity Procedure: Oral glucose tolerance test National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Phase 2 2003-07-25 2017-01-24
    NCT01881919 Hyperuricemia|Gout|Kidney Calculi|Diabetes|Cardiovascular Disease Dietary Supplement: Treatment|Dietary Supplement: Control University of Leeds Early Phase 1 2013-02-01 2015-03-20
    NCT00913081 Flushing Dietary Supplement: Quercetin|Dietary Supplement: Placebo University of Pennsylvania|Abbott Phase 4 2009-02-01 2015-02-19
    NCT01847521 Autism Spectrum Disorders Dietary Supplement: Luteolin, Quercetin and Rutin combined in a capsule Attikon Hospital Phase 2 2011-12-01 2013-05-02
    NCT01348204 Cystic Fibrosis Other: quercetin University of Alabama at Birmingham|National Institutes of Health (NIH) Phase 2 2010-03-01 2012-01-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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