槲皮素是一具抗癌活性的类黄酮。
Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Navarro-Nunez L, et al. Fitoterapia, 2010, 81(2):75-80.
[2] Tiong, K.H., et al. 2010. Xenobiotica. 40: 458-466.
[3] Li, B.H. and Tian, W.X. 2003. J Enzyme Inhib Med Chem. 18: 349-356.
[4] Lupu, R. and Menendez, J.A. 2006. Curr Pharm Biotechnol. 7: 483-493.
分子式 C15H10O7 |
分子量 302.24 |
CAS号 117-39-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water <1 mg/mL |
Ethanol 2 mg/mL |
体内溶解度
NCT01708278 | Chronic Obstructive Pulmonary Disease | Drug: Quercetin|Other: Placebo - sugar chew | University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) | Phase 1 | 2014-02-01 | 2016-10-31 |
NCT01376011 | Stroke|Problem of Aging | Dietary Supplement: quercetin/placebo | Brigham and Women's Hospital|National Institute on Aging (NIA) | Early Phase 1 | 2009-06-01 | 2015-01-26 |
NCT01720147 | Fanconi Anemia | Drug: Quercetin (dietary supplement) | Children's Hospital Medical Center, Cincinnati | Phase 1 | 2012-07-01 | 2016-08-19 |
NCT02226484 | Gastroesophageal Reflux Disease|GERD|Acid Reflux|Reflux | Drug: Quercetin | University of North Carolina, Chapel Hill|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 1 | 2014-08-01 | 2016-12-19 |
NCT01438320 | Chronic Hepatitis C | Dietary Supplement: Quercetin | University of California, Los Angeles|American Association for Cancer Research|Tower Cancer Research Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 1 | 2011-07-01 | 2015-03-18 |
NCT00402623 | Sarcoidosis | Dietary Supplement: quercetin|Other: placebo | Maastricht University Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development | 2006-01-01 | 2017-02-22 | |
NCT01691404 | Hypertension|Endothelial Dysfunction | Dietary Supplement: Epicatechin|Dietary Supplement: Quercetin|Dietary Supplement: Placebo | Wageningen University|Top Institute Food and Nutrition | 2012-09-01 | 2013-04-22 | |
NCT01732393 | Chemotherapy Induced Oral Mucositis | Drug: oral quercetin capsules|Drug: Placebo | Mashhad University of Medical Sciences | Phase 1|Phase 2 | 2010-01-01 | 2012-12-04 |
NCT01168739 | Heat Acclimation and Thermotolerance | Dietary Supplement: Quercetin|Dietary Supplement: Placebo | University of New Mexico|Gatorade Sports and Science Institute|Quercegen Pharmaceuticals|Nash Finch Company | 2009-09-01 | 2010-07-21 | |
NCT01912820 | Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer | Dietary Supplement: green tea extract|Drug: quercetin|Other: placebo|Procedure: therapeutic conventional surgery|Other: laboratory biomarker analysis | Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) | Phase 1 | 2014-01-01 | 2016-09-12 |
NCT01722669 | Healthy | Drug: isoquercetin or quercetin | Beth Israel Deaconess Medical Center | Early Phase 1 | 2012-05-01 | 2017-03-02 |
NCT01839344 | Diabetes Mellitus, Type 2 | Dietary Supplement: Quercetin|Drug: Acarbose|Drug: placebo | Bastyr University | Phase 2 | 2013-05-01 | 2015-03-16 |
NCT01375101 | Atrophic Oral Lichen Planus|Erosive Oral Lichen Planus | Drug: placebo|Drug: Quercetin | Mashhad University of Medical Sciences | Phase 1 | 2010-04-01 | 2011-07-25 |
NCT01538316 | Primary Prevention of Prostate Cancer | Dietary Supplement: Quercetin supplement|Dietary Supplement: Genistein supplement|Dietary Supplement: Placebo | University of Hohenheim|University Hospital Tuebingen|Quercegen Pharmaceuticals | 2012-03-01 | 2012-05-13 | |
NCT02989129 | Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain | Behavioral: Questionnaires|Drug: Quercetin | M.D. Anderson Cancer Center | Early Phase 1 | 2017-03-01 | 2016-12-12 |
NCT00065676 | Diabetes Mellitus|Obesity | Procedure: Oral glucose tolerance test | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2003-07-25 | 2017-01-24 |
NCT01881919 | Hyperuricemia|Gout|Kidney Calculi|Diabetes|Cardiovascular Disease | Dietary Supplement: Treatment|Dietary Supplement: Control | University of Leeds | Early Phase 1 | 2013-02-01 | 2015-03-20 |
NCT00913081 | Flushing | Dietary Supplement: Quercetin|Dietary Supplement: Placebo | University of Pennsylvania|Abbott | Phase 4 | 2009-02-01 | 2015-02-19 |
NCT01847521 | Autism Spectrum Disorders | Dietary Supplement: Luteolin, Quercetin and Rutin combined in a capsule | Attikon Hospital | Phase 2 | 2011-12-01 | 2013-05-02 |
NCT01348204 | Cystic Fibrosis | Other: quercetin | University of Alabama at Birmingham|National Institutes of Health (NIH) | Phase 2 | 2010-03-01 | 2012-01-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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